Gene description for FBP2
Gene name fructose-1,6-bisphosphatase 2
Gene symbol FBP2
Other names/aliases -
Species Homo sapiens
 Database cross references - FBP2
ExoCarta ExoCarta_8789
Vesiclepedia VP_8789
Entrez Gene 8789
HGNC 3607
MIM 603027
UniProt O00757  
 FBP2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for FBP2
Molecular Function
    protein binding GO:0005515 IPI
    fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132 IBA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    fructose metabolic process GO:0006000 IBA
    fructose 6-phosphate metabolic process GO:0006002 IBA
    gluconeogenesis GO:0006094 IBA
    gluconeogenesis GO:0006094 IEA
    fructose 1,6-bisphosphate metabolic process GO:0030388 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    Z disc GO:0030018 IEA
    extracellular exosome GO:0070062 HDA
    anchoring junction GO:0070161 IEA
 Experiment description of studies that identified FBP2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABTB2 25841
Affinity Capture-MS Homo sapiens
2 MLXIPL  
Affinity Capture-MS Homo sapiens
3 FBP2 8789
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 FBP1 2203
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
5 CHD3 1107
Two-hybrid Homo sapiens
6 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
7 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FBP2 is involved
PathwayEvidenceSource
Gluconeogenesis TAS Reactome
Glucose metabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of carbohydrates TAS Reactome





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