Gene description for HIST2H2BE
Gene name histone cluster 2, H2be
Gene symbol HIST2H2BE
Other names/aliases GL105
H2B
H2B.1
H2BFQ
H2BGL105
H2BQ
Species Homo sapiens
 Database cross references - HIST2H2BE
ExoCarta ExoCarta_8349
Vesiclepedia VP_8349
Entrez Gene 8349
HGNC 4760
MIM 601831
UniProt Q16778  
 HIST2H2BE identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Endothelial cells 26027894    
Mesenchymal stem cells Unpublished / Not applicable
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Saliva 19199708    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for HIST2H2BE
Molecular Function
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IDA
    nucleosome assembly GO:0006334 NAS
    antibacterial humoral response GO:0019731 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    nucleosome GO:0000786 NAS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST2H2BE in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 282
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 283
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
9
Experiment ID 285
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
10
Experiment ID 286
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
11
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 226
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
13
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
14
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
15
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 138
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
18
Experiment ID 139
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
19
Experiment ID 140
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
20
Experiment ID 141
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
21
Experiment ID 142
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
22
Experiment ID 143
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
23
Experiment ID 145
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
24
Experiment ID 146
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
25
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
26
Experiment ID 274
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
27
Experiment ID 66
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
28
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HIST2H2BE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
2 HDAC2 3066
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
3 UBE2A  
Biochemical Activity Homo sapiens
4 JMJD1C 221037
Affinity Capture-MS Homo sapiens
5 PRPF8 10594
Affinity Capture-MS Homo sapiens
6 RIN3  
Affinity Capture-MS Homo sapiens
7 JADE3  
Affinity Capture-MS Homo sapiens
8 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
9 NMNAT1  
Affinity Capture-MS Homo sapiens
10 SMARCE1 6605
Affinity Capture-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 ZZZ3  
Affinity Capture-MS Homo sapiens
13 BRD2  
Protein-peptide Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
14 MAP4K4 9448
Two-hybrid Homo sapiens
15 SCAF4 57466
Affinity Capture-MS Homo sapiens
16 SMARCD2 6603
Affinity Capture-MS Homo sapiens
17 PRKDC 5591
Affinity Capture-MS Homo sapiens
18 CENPA  
Co-purification Homo sapiens
19 WDR76  
Affinity Capture-MS Homo sapiens
20 CBX1 10951
Affinity Capture-MS Homo sapiens
21 MEAF6  
Affinity Capture-MS Homo sapiens
22 MTF2  
Affinity Capture-MS Homo sapiens
23 CHAF1A  
Affinity Capture-MS Homo sapiens
24 KIF23 9493
Affinity Capture-MS Homo sapiens
25 CTDSPL2  
Affinity Capture-MS Homo sapiens
26 RNF8  
Biochemical Activity Homo sapiens
27 CDK2AP1  
Affinity Capture-MS Homo sapiens
28 OIP5  
Affinity Capture-MS Homo sapiens
29 ATAD5  
Affinity Capture-MS Homo sapiens
30 SMC2 10592
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
31 POLR2C 5432
Affinity Capture-MS Homo sapiens
32 MECP2 4204
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
33 WDR5 11091
Affinity Capture-MS Homo sapiens
34 PSMD14 10213
Affinity Capture-MS Homo sapiens
35 MTA2 9219
Affinity Capture-MS Homo sapiens
36 UIMC1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 LRIF1  
Affinity Capture-MS Homo sapiens
38 TFAP2A  
Affinity Capture-MS Homo sapiens
39 BRPF1  
Affinity Capture-MS Homo sapiens
40 MRE11A 4361
Affinity Capture-MS Homo sapiens
41 TOP2B 7155
Affinity Capture-MS Homo sapiens
42 ATAD2 29028
Affinity Capture-MS Homo sapiens
43 CTBP1 1487
Affinity Capture-MS Homo sapiens
44 SUPT5H 6829
Affinity Capture-MS Homo sapiens
45 MAPRE1 22919
Affinity Capture-MS Homo sapiens
46 ZMYM3  
Affinity Capture-MS Homo sapiens
47 HIST1H3E 8353
Co-purification Homo sapiens
48 MNAT1  
Affinity Capture-MS Homo sapiens
49 SRBD1  
Affinity Capture-MS Homo sapiens
50 IWS1  
Affinity Capture-MS Homo sapiens
51 CBX5 23468
Affinity Capture-MS Homo sapiens
52 BANF1 8815
Affinity Capture-MS Homo sapiens
53 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
54 RFC4 5984
Affinity Capture-MS Homo sapiens
55 MED25  
Affinity Capture-MS Homo sapiens
56 WHSC1L1  
Affinity Capture-MS Homo sapiens
57 SCOC 60592
Affinity Capture-MS Homo sapiens
58 SPANXN2  
Two-hybrid Homo sapiens
59 AHCTF1 25909
Affinity Capture-MS Homo sapiens
60 BRCA1 672
Affinity Capture-MS Homo sapiens
61 PARP3 10039
Affinity Capture-MS Homo sapiens
62 BCLAF1 9774
Affinity Capture-MS Homo sapiens
63 BRD7  
Affinity Capture-MS Homo sapiens
64 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
65 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
66 RNF40 9810
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
67 ZNF280D  
Affinity Capture-MS Homo sapiens
68 DNAJC21  
Affinity Capture-MS Homo sapiens
69 TSPY1  
Reconstituted Complex Homo sapiens
70 KDM5B  
Affinity Capture-MS Homo sapiens
71 LMNB1 4001
Affinity Capture-MS Homo sapiens
72 SIRT7  
Reconstituted Complex Homo sapiens
73 BCAP31 10134
Cross-Linking-MS (XL-MS) Homo sapiens
74 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
Reconstituted Complex Homo sapiens
75 CUL3 8452
Affinity Capture-MS Homo sapiens
76 POLR2D  
Affinity Capture-MS Homo sapiens
77 GZMA 3001
Biochemical Activity Homo sapiens
78 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 SENP7  
Affinity Capture-MS Homo sapiens
80 NTHL1  
Affinity Capture-MS Homo sapiens
81 PPHLN1  
Affinity Capture-MS Homo sapiens
82 ZNF512  
Affinity Capture-MS Homo sapiens
83 ESCO1  
Affinity Capture-MS Homo sapiens
84 ZMYND8 23613
Affinity Capture-MS Homo sapiens
85 ING5  
Affinity Capture-MS Homo sapiens
86 PHC1  
Affinity Capture-MS Homo sapiens
87 BRD4 23476
Affinity Capture-MS Homo sapiens
88 TBL1X 6907
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
89 ZNF687  
Affinity Capture-MS Homo sapiens
90 Prkaca 25636
Biochemical Activity Rattus norvegicus
91 AKT1 207
Biochemical Activity Homo sapiens
92 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
93 SUPT16H 11198
Affinity Capture-MS Homo sapiens
94 USP49 25862
Biochemical Activity Homo sapiens
95 DNMT3L  
Reconstituted Complex Homo sapiens
96 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
97 KAT8  
Affinity Capture-MS Homo sapiens
98 ARID2  
Affinity Capture-MS Homo sapiens
99 HIST1H2AC 8334
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
100 USP46 64854
Biochemical Activity Homo sapiens
101 MBD3 53615
Affinity Capture-MS Homo sapiens
102 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 KMT2B  
Affinity Capture-MS Homo sapiens
104 KDM1B  
Affinity Capture-MS Homo sapiens
105 POLE3  
Affinity Capture-MS Homo sapiens
106 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
107 Atrx  
Affinity Capture-MS Mus musculus
108 MORF4L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 DCTN2 10540
Affinity Capture-MS Homo sapiens
110 MTA1 9112
Affinity Capture-MS Homo sapiens
111 CWF19L2  
Cross-Linking-MS (XL-MS) Homo sapiens
112 PARP2  
Affinity Capture-MS Homo sapiens
113 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
114 PRAME  
Affinity Capture-MS Homo sapiens
115 WWP2 11060
Affinity Capture-MS Homo sapiens
116 LONP1 9361
Affinity Capture-MS Homo sapiens
117 NCL 4691
Reconstituted Complex Homo sapiens
118 PSMA5 5686
Affinity Capture-MS Homo sapiens
119 SUPT6H 6830
Affinity Capture-MS Homo sapiens
120 MAU2  
Affinity Capture-MS Homo sapiens
121 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
122 EHMT1  
Affinity Capture-MS Homo sapiens
123 CUL7 9820
Affinity Capture-MS Homo sapiens
124 LOX 4015
Reconstituted Complex Homo sapiens
125 ATXN7L3  
Biochemical Activity Homo sapiens
126 GATAD1  
Affinity Capture-MS Homo sapiens
127 C17orf80 55028
Affinity Capture-MS Homo sapiens
128 PWWP2A  
Affinity Capture-MS Homo sapiens
129 PHF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 CHD4 1108
Affinity Capture-MS Homo sapiens
131 EPC2  
Affinity Capture-MS Homo sapiens
132 CDCA5  
Affinity Capture-MS Homo sapiens
133 MCM3 4172
Affinity Capture-MS Homo sapiens
134 ORC2  
Affinity Capture-MS Homo sapiens
135 msl-1  
Biochemical Activity Drosophila melanogaster
136 MRPL48  
Affinity Capture-MS Homo sapiens
137 MLLT10  
Affinity Capture-MS Homo sapiens
138 GTF3C5 9328
Affinity Capture-MS Homo sapiens
139 ANP32A 8125
Reconstituted Complex Homo sapiens
140 HIST1H4G 8369
Cross-Linking-MS (XL-MS) Homo sapiens
141 TEX35  
Cross-Linking-MS (XL-MS) Homo sapiens
142 CTBP2 1488
Affinity Capture-MS Homo sapiens
143 DNTTIP1 116092
Affinity Capture-MS Homo sapiens
144 BTF3 689
Affinity Capture-MS Homo sapiens
145 ZNF638 27332
Affinity Capture-MS Homo sapiens
146 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
147 CAND1 55832
Affinity Capture-MS Homo sapiens
148 PSIP1 11168
Affinity Capture-MS Homo sapiens
149 XRCC1 7515
Affinity Capture-MS Homo sapiens
150 MBIP  
Affinity Capture-MS Homo sapiens
151 SRCAP  
Affinity Capture-MS Homo sapiens
152 KIF22  
Affinity Capture-MS Homo sapiens
153 H1FX 8971
Affinity Capture-MS Homo sapiens
154 SPIN1  
Affinity Capture-MS Homo sapiens
155 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
156 HIST2H3A 333932
Affinity Capture-MS Homo sapiens
157 ARID4B  
Affinity Capture-MS Homo sapiens
158 NPM1 4869
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
159 SRRM2 23524
Affinity Capture-MS Homo sapiens
160 MED27  
Affinity Capture-MS Homo sapiens
161 OBSL1 23363
Affinity Capture-MS Homo sapiens
162 NEDD8-MDP1 100528064
Affinity Capture-MS Homo sapiens
163 MKI67  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 TMEM192 201931
Affinity Capture-MS Homo sapiens
165 MSL2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
166 ZNF644  
Affinity Capture-MS Homo sapiens
167 WIZ 58525
Affinity Capture-MS Homo sapiens
168 CUL1 8454
Affinity Capture-MS Homo sapiens
169 USP7 7874
Affinity Capture-MS Homo sapiens
170 VRK3 51231
Affinity Capture-MS Homo sapiens
171 RLF 6018
Affinity Capture-MS Homo sapiens
172 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
173 HIST1H4A 8359
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
174 WHSC1 7468
Affinity Capture-MS Homo sapiens
175 EIF2A 83939
Cross-Linking-MS (XL-MS) Homo sapiens
176 NBN 4683
Affinity Capture-MS Homo sapiens
177 RECQL 5965
Affinity Capture-MS Homo sapiens
178 TRIM24  
Affinity Capture-MS Homo sapiens
179 VRK1 7443
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
180 CFDP1  
Affinity Capture-MS Homo sapiens
181 RAG1  
Far Western Homo sapiens
182 NELFE 7936
Affinity Capture-MS Homo sapiens
183 BPTF 2186
Affinity Capture-MS Homo sapiens
184 TOX4  
Affinity Capture-MS Homo sapiens
185 RCC1 1104
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
186 SCAF11  
Affinity Capture-MS Homo sapiens
187 CTR9 9646
Affinity Capture-MS Homo sapiens
188 APTX  
Affinity Capture-MS Homo sapiens
189 POLB 5423
Affinity Capture-MS Homo sapiens
190 PPM1G 5496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
192 TPX2  
Affinity Capture-MS Homo sapiens
193 CHRAC1  
Affinity Capture-MS Homo sapiens
194 SMCHD1 23347
Affinity Capture-MS Homo sapiens
195 LEO1 123169
Affinity Capture-MS Homo sapiens
196 USP15 9958
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
197 JADE1  
Affinity Capture-MS Homo sapiens
198 POLR2E 5434
Affinity Capture-MS Homo sapiens
199 TAF1B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
200 PHIP 55023
Affinity Capture-MS Homo sapiens
201 CSRP2BP  
Affinity Capture-MS Homo sapiens
202 FUS 2521
Affinity Capture-MS Homo sapiens
203 MORF4L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
204 CCDC71  
Affinity Capture-MS Homo sapiens
205 ELMSAN1  
Affinity Capture-MS Homo sapiens
206 TOMM70A 9868
Cross-Linking-MS (XL-MS) Homo sapiens
207 ACTR6  
Affinity Capture-MS Homo sapiens
208 CDK2 1017
Affinity Capture-MS Homo sapiens
209 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
210 MYC  
Affinity Capture-MS Homo sapiens
211 FAM91A1 157769
Affinity Capture-MS Homo sapiens
212 EP400  
Affinity Capture-MS Homo sapiens
213 INTS3 65123
Affinity Capture-MS Homo sapiens
214 EHMT2 10919
Affinity Capture-MS Homo sapiens
215 NIPBL 25836
Affinity Capture-MS Homo sapiens
216 RAI1 10743
Affinity Capture-MS Homo sapiens
217 SART3 9733
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
218 DDB1 1642
Affinity Capture-MS Homo sapiens
219 CBX2  
Affinity Capture-MS Homo sapiens
220 msl-2  
Biochemical Activity Drosophila melanogaster
221 HMG20A  
Affinity Capture-MS Homo sapiens
222 HUWE1 10075
Affinity Capture-MS Homo sapiens
223 GATAD2A 54815
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
224 NEIL3  
Protein-RNA Homo sapiens
225 TERF2  
Affinity Capture-MS Homo sapiens
226 DIDO1  
Affinity Capture-MS Homo sapiens
227 ILF3 3609
Affinity Capture-RNA Homo sapiens
228 H3F3A 3020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
229 TP53 7157
Affinity Capture-MS Homo sapiens
230 FOLR1 2348
Affinity Capture-MS Homo sapiens
231 ZWILCH 55055
Affinity Capture-MS Homo sapiens
232 PHF3  
Affinity Capture-MS Homo sapiens
233 RIF1  
Affinity Capture-MS Homo sapiens
234 HLTF  
Affinity Capture-MS Homo sapiens
235 CENPF 1063
Affinity Capture-MS Homo sapiens
236 QSER1  
Affinity Capture-MS Homo sapiens
237 RNF20 56254
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
238 RAD50 10111
Affinity Capture-MS Homo sapiens
239 TRIP12 9320
Affinity Capture-MS Homo sapiens
240 LCOR 84458
Affinity Capture-MS Homo sapiens
241 BRD1 23774
Affinity Capture-MS Homo sapiens
242 GLYR1 84656
Affinity Capture-MS Homo sapiens
243 KAT6A  
Affinity Capture-MS Homo sapiens
244 SMARCAL1  
Affinity Capture-MS Homo sapiens
245 PHC2  
Affinity Capture-MS Homo sapiens
246 CKAP4 10970
Affinity Capture-MS Homo sapiens
247 Uhrf1  
Affinity Capture-Western Mus musculus
Far Western Mus musculus
248 RCOR1  
Affinity Capture-MS Homo sapiens
249 CUL4A 8451
Affinity Capture-MS Homo sapiens
250 XPC  
Affinity Capture-MS Homo sapiens
251 MCM7 4176
Affinity Capture-MS Homo sapiens
252 GATAD2B 57459
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
253 ORC4  
Affinity Capture-MS Homo sapiens
254 MDC1  
Affinity Capture-MS Homo sapiens
255 ANAPC5 51433
Affinity Capture-MS Homo sapiens
256 EPB41L3 23136
Affinity Capture-MS Homo sapiens
257 PRMT6  
Biochemical Activity Homo sapiens
258 NABP2  
Affinity Capture-MS Homo sapiens
259 RFC5 5985
Affinity Capture-MS Homo sapiens
260 SAMD1  
Affinity Capture-MS Homo sapiens
261 PPP1R10  
Affinity Capture-MS Homo sapiens
262 PCGF2 7703
Affinity Capture-MS Homo sapiens
263 INTS9 55756
Affinity Capture-MS Homo sapiens
264 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
265 KAT7  
Affinity Capture-MS Homo sapiens
266 RUVBL1 8607
Affinity Capture-MS Homo sapiens
267 WDR48 57599
Affinity Capture-MS Homo sapiens
268 CDC16 8881
Affinity Capture-MS Homo sapiens
269 HIST1H2BM 8342
Cross-Linking-MS (XL-MS) Homo sapiens
270 MCM2 4171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
271 SMARCA1 6594
Affinity Capture-MS Homo sapiens
272 KDM2A  
Affinity Capture-MS Homo sapiens
273 FBXO28  
Affinity Capture-MS Homo sapiens
274 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
275 BRPF3  
Affinity Capture-MS Homo sapiens
276 MCM6 4175
Affinity Capture-MS Homo sapiens
277 HCFC2  
Affinity Capture-MS Homo sapiens
278 BCORL1  
Affinity Capture-MS Homo sapiens
279 HIST2H2AC 8338
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
280 ATRX 546
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
281 ZNF518B  
Affinity Capture-MS Homo sapiens
282 TICRR 90381
Affinity Capture-MS Homo sapiens
283 YEATS2  
Affinity Capture-MS Homo sapiens
284 PALB2  
Affinity Capture-Western Homo sapiens
285 UBQLN4 56893
Affinity Capture-MS Homo sapiens
286 MSL3  
Affinity Capture-MS Homo sapiens
287 FEN1 2237
Affinity Capture-MS Homo sapiens
288 PPM1D  
Affinity Capture-MS Homo sapiens
289 USP12 219333
Biochemical Activity Homo sapiens
290 SHPRH  
Affinity Capture-MS Homo sapiens
291 KAT6B  
Affinity Capture-MS Homo sapiens
292 CUL4B 8450
Affinity Capture-MS Homo sapiens
293 PARK2  
Affinity Capture-MS Homo sapiens
294 PNKP 11284
Affinity Capture-MS Homo sapiens
295 EXO1  
Affinity Capture-MS Homo sapiens
296 PHF14 9678
Affinity Capture-MS Homo sapiens
297 MARS 4141
Affinity Capture-MS Homo sapiens
298 BLM 641
Affinity Capture-MS Homo sapiens
299 NAA40  
Affinity Capture-MS Homo sapiens
300 CBX3 11335
Affinity Capture-MS Homo sapiens
301 USP8 9101
Biochemical Activity Homo sapiens
302 DEK 7913
Affinity Capture-Western Homo sapiens
303 SAFB2 9667
Affinity Capture-MS Homo sapiens
304 BARD1 580
Affinity Capture-MS Homo sapiens
305 DPF2  
Affinity Capture-MS Homo sapiens
306 LRWD1  
Affinity Capture-MS Homo sapiens
307 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
308 SCML2  
Affinity Capture-MS Homo sapiens
309 PARP10 84875
Biochemical Activity Homo sapiens
310 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
311 PHF12  
Affinity Capture-MS Homo sapiens
312 PELP1 27043
Reconstituted Complex Homo sapiens
313 LATS2 26524
Affinity Capture-Western Homo sapiens
314 DNTTIP2  
Affinity Capture-MS Homo sapiens
315 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
316 IPO9 55705
Affinity Capture-MS Homo sapiens
317 POLR2B 5431
Affinity Capture-MS Homo sapiens
318 DDX26B  
Affinity Capture-MS Homo sapiens
319 NUP37 79023
Affinity Capture-MS Homo sapiens
320 USP42  
Affinity Capture-Western Homo sapiens
321 KMT2A  
Affinity Capture-MS Homo sapiens
322 CDC73  
Affinity Capture-Western Homo sapiens
323 MSH2 4436
Affinity Capture-MS Homo sapiens
324 BAZ1B 9031
Affinity Capture-MS Homo sapiens
325 SMARCD1 6602
Affinity Capture-MS Homo sapiens
326 SMARCA5 8467
Affinity Capture-MS Homo sapiens
327 FAM60A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
328 RPRD2  
Affinity Capture-MS Homo sapiens
329 PHF2  
Affinity Capture-MS Homo sapiens
330 DDB2  
Affinity Capture-MS Homo sapiens
331 H1F0 3005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
332 POLR2A 5430
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
333 RFC1 5981
Affinity Capture-MS Homo sapiens
334 AP2M1 1173
Two-hybrid Homo sapiens
335 ARID1B 57492
Reconstituted Complex Homo sapiens
336 MED10  
Affinity Capture-MS Homo sapiens
337 GNB2 2783
Affinity Capture-Western Homo sapiens
338 MSL1 339287
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
339 HP1BP3 50809
Affinity Capture-MS Homo sapiens
340 PCGF1 84759
Affinity Capture-MS Homo sapiens
341 PARP1 142
Affinity Capture-MS Homo sapiens
342 RNF2  
Affinity Capture-MS Homo sapiens
343 STK4 6789
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
344 HSPD1 3329
Affinity Capture-Western Homo sapiens
345 RBBP5 5929
Affinity Capture-MS Homo sapiens
346 CPSF3L 54973
Affinity Capture-MS Homo sapiens
347 ANAPC4 29945
Affinity Capture-MS Homo sapiens
348 TAF1A  
Reconstituted Complex Homo sapiens
349 XRCC5 7520
Affinity Capture-MS Homo sapiens
350 CHD7  
Affinity Capture-MS Homo sapiens
351 CBX4  
Affinity Capture-MS Homo sapiens
352 DZIP3  
Affinity Capture-Western Homo sapiens
353 LAMB1 3912
Affinity Capture-MS Homo sapiens
354 HMGN4  
Cross-Linking-MS (XL-MS) Homo sapiens
355 LIG3 3980
Affinity Capture-MS Homo sapiens
356 CUL2 8453
Affinity Capture-MS Homo sapiens
357 MTBP  
Affinity Capture-MS Homo sapiens
358 STK38 11329
Biochemical Activity Homo sapiens
359 MCM5 4174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
360 KAT2B  
Biochemical Activity Homo sapiens
361 CHAMP1  
Affinity Capture-MS Homo sapiens
362 MEN1 4221
Affinity Capture-MS Homo sapiens
363 PBRM1 55193
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
364 CREBBP  
Biochemical Activity Homo sapiens
365 CHD1L 9557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
366 KDM6B 23135
Affinity Capture-MS Homo sapiens
367 ZNF280C  
Affinity Capture-MS Homo sapiens
368 PCNA 5111
Affinity Capture-MS Homo sapiens
369 HMGXB4 10042
Affinity Capture-MS Homo sapiens
370 KDM1A 23028
Affinity Capture-MS Homo sapiens
371 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
372 TCF20  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
373 RPRD1B 58490
Affinity Capture-MS Homo sapiens
374 ORC1  
Affinity Capture-MS Homo sapiens
375 SERBP1 26135
Affinity Capture-MS Homo sapiens
376 UHRF1 29128
Affinity Capture-MS Homo sapiens
377 RSF1  
Affinity Capture-MS Homo sapiens
378 NUCKS1 64710
Affinity Capture-MS Homo sapiens
379 POGZ 23126
Affinity Capture-MS Homo sapiens
380 KIF4A 24137
Affinity Capture-MS Homo sapiens
381 ATG3 64422
Affinity Capture-MS Homo sapiens
382 EP300 2033
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
383 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
384 HIST1H2AI 8329
Cross-Linking-MS (XL-MS) Homo sapiens
385 RPS6KA5 9252
Biochemical Activity Homo sapiens
386 ZNF292  
Affinity Capture-MS Homo sapiens
387 AP2B1 163
Affinity Capture-MS Homo sapiens
388 MSH6 2956
Affinity Capture-MS Homo sapiens
389 RACGAP1 29127
Affinity Capture-MS Homo sapiens
390 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
391 FBXO25  
Affinity Capture-MS Homo sapiens
392 SUB1 10923
Affinity Capture-MS Homo sapiens
393 MED9  
Affinity Capture-MS Homo sapiens
394 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
395 SAP30 8819
Reconstituted Complex Homo sapiens
396 INCENP 3619
Affinity Capture-MS Homo sapiens
397 IL33  
Reconstituted Complex Homo sapiens
398 CDCA7L  
Affinity Capture-MS Homo sapiens
399 TOP2A 7153
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
400 VPS72  
Affinity Capture-MS Homo sapiens
401 CDK14 5218
Affinity Capture-MS Homo sapiens
402 SSRP1 6749
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
403 TBL1XR1 79718
Reconstituted Complex Homo sapiens
404 INIP  
Affinity Capture-MS Homo sapiens
405 COPS5 10987
Affinity Capture-MS Homo sapiens
406 FBXW7  
Affinity Capture-MS Homo sapiens
407 C4orf27  
Affinity Capture-MS Homo sapiens
408 H2AFY2 55506
Affinity Capture-MS Homo sapiens
409 HMGA1 3159
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
410 UBQLN1 29979
Affinity Capture-MS Homo sapiens
411 CDC27 996
Affinity Capture-MS Homo sapiens
412 INTS6 26512
Affinity Capture-MS Homo sapiens
413 BCOR  
Affinity Capture-MS Homo sapiens
414 ANAPC7 51434
Affinity Capture-MS Homo sapiens
415 ASH2L 9070
Affinity Capture-MS Homo sapiens
416 NAP1L4 4676
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
417 SMARCB1 6598
Affinity Capture-MS Homo sapiens
418 PDS5B 23047
Cross-Linking-MS (XL-MS) Homo sapiens
419 CCDC86  
Affinity Capture-MS Homo sapiens
420 USP22 23326
Biochemical Activity Homo sapiens
421 H2AFZ 3015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
422 MRPL32 64983
Affinity Capture-MS Homo sapiens
423 RBBP7 5931
Affinity Capture-MS Homo sapiens
424 ING4  
Affinity Capture-MS Homo sapiens
425 TNN 63923
Cross-Linking-MS (XL-MS) Homo sapiens
426 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
427 RSRC1  
Affinity Capture-MS Homo sapiens
428 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
429 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
430 ZNF22  
Affinity Capture-MS Homo sapiens
431 PRDM2  
Affinity Capture-MS Homo sapiens
432 SMARCA4 6597
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
433 NOC2L 26155
Affinity Capture-MS Homo sapiens
434 RNF168  
Affinity Capture-Western Homo sapiens
435 ACTL6A 86
Affinity Capture-MS Homo sapiens
436 ANAPC10  
Affinity Capture-MS Homo sapiens
437 EED  
Affinity Capture-MS Homo sapiens
438 CYLC1 1538
Cross-Linking-MS (XL-MS) Homo sapiens
439 H2AFY 9555
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
440 DAXX  
Affinity Capture-MS Homo sapiens
441 ARID4A  
Affinity Capture-MS Homo sapiens
442 SMARCC2 6601
Affinity Capture-MS Homo sapiens
443 ZMYM4  
Affinity Capture-MS Homo sapiens
444 WDR82 80335
Affinity Capture-MS Homo sapiens
445 HIST1H2AA 221613
Cross-Linking-MS (XL-MS) Homo sapiens
446 NUMA1 4926
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
447 PKMYT1  
Affinity Capture-MS Homo sapiens
448 TAF15 8148
Affinity Capture-MS Homo sapiens
449 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
450 PINK1  
Affinity Capture-MS Homo sapiens
451 CDCA8 55143
Affinity Capture-MS Homo sapiens
452 PNN 5411
Affinity Capture-MS Homo sapiens
453 RNF169  
Affinity Capture-Western Homo sapiens
454 RFC2 5982
Affinity Capture-MS Homo sapiens
455 HCFC1 3054
Affinity Capture-MS Homo sapiens
456 NSD1  
Affinity Capture-MS Homo sapiens
457 TET1  
Affinity Capture-MS Homo sapiens
458 CDK5R2 8941
Cross-Linking-MS (XL-MS) Homo sapiens
459 CKAP2  
Affinity Capture-MS Homo sapiens
460 ADNP 23394
Affinity Capture-MS Homo sapiens
461 TOP3A  
Affinity Capture-MS Homo sapiens
462 MRGBP  
Affinity Capture-MS Homo sapiens
463 MCM4 4173
Affinity Capture-MS Homo sapiens
464 NAP1L1 4673
Affinity Capture-MS Homo sapiens
465 PYCR2 29920
Affinity Capture-MS Homo sapiens
466 SUZ12  
Affinity Capture-MS Homo sapiens
467 AURKB 9212
Affinity Capture-Western Homo sapiens
468 CDYL 9425
Affinity Capture-MS Homo sapiens
469 SAGE1  
Affinity Capture-MS Homo sapiens
470 L3MBTL3  
Affinity Capture-MS Homo sapiens
471 IL7R  
Protein-RNA Homo sapiens
472 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
473 RREB1 6239
Affinity Capture-MS Homo sapiens
474 MMS22L  
Affinity Capture-MS Homo sapiens
475 BAZ1A 11177
Affinity Capture-MS Homo sapiens
476 CHD8 57680
Affinity Capture-MS Homo sapiens
477 ARID1A 8289
Affinity Capture-MS Homo sapiens
478 ANP32E 81611
Affinity Capture-MS Homo sapiens
479 ZMYM2  
Affinity Capture-MS Homo sapiens
480 MDM2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
481 H2AFX 3014
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
482 KAT2A  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
483 NUP133 55746
Affinity Capture-MS Homo sapiens
484 ERH 2079
Affinity Capture-MS Homo sapiens
485 SMARCC1 6599
Affinity Capture-MS Homo sapiens
486 DPY30 84661
Affinity Capture-MS Homo sapiens
487 CUL5 8065
Affinity Capture-MS Homo sapiens
488 SMURF1 57154
Affinity Capture-MS Homo sapiens
489 ANAPC1 64682
Affinity Capture-MS Homo sapiens
490 HDAC1 3065
Affinity Capture-MS Homo sapiens
491 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
492 HDGF 3068
Affinity Capture-Western Homo sapiens
493 BCL7A  
Affinity Capture-MS Homo sapiens
494 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
495 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
496 H2AFJ 55766
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
497 NUP107 57122
Affinity Capture-MS Homo sapiens
498 EZH2  
Affinity Capture-MS Homo sapiens
499 KIF18B 146909
Affinity Capture-MS Homo sapiens
500 AIRE  
Reconstituted Complex Homo sapiens
501 CDK9 1025
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
502 CBX8 57332
Affinity Capture-MS Homo sapiens
503 XRCC6 2547
Affinity Capture-MS Homo sapiens
504 HIPK2 28996
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
505 PHF10  
Affinity Capture-MS Homo sapiens
506 PAF1 54623
Affinity Capture-MS Homo sapiens
507 TOP1MT  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HIST2H2BE is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





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