Gene description for COMMD3-BMI1
Gene name COMMD3-BMI1 readthrough
Gene symbol COMMD3-BMI1
Other names/aliases -
Species Homo sapiens
 Database cross references - COMMD3-BMI1
ExoCarta ExoCarta_100532731
Vesiclepedia VP_100532731
Entrez Gene 100532731
HGNC 48326
UniProt P35226  
 COMMD3-BMI1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for COMMD3-BMI1
 Experiment description of studies that identified COMMD3-BMI1 in sEVs
1
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for COMMD3-BMI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC93 54520
Affinity Capture-MS Homo sapiens
2 VPS29 51699
Affinity Capture-MS Homo sapiens
3 H2AFZ 3015
Affinity Capture-MS Homo sapiens
4 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
5 RING1 6015
Affinity Capture-MS Homo sapiens
6 CCDC22 28952
Affinity Capture-MS Homo sapiens
7 HMGN5 79366
Affinity Capture-MS Homo sapiens
8 COMMD2 51122
Affinity Capture-MS Homo sapiens
9 NANOG  
Affinity Capture-MS Homo sapiens
10 HMGA1 3159
Affinity Capture-MS Homo sapiens
11 COMMD4 54939
Affinity Capture-MS Homo sapiens
12 COMMD6 170622
Affinity Capture-MS Homo sapiens
13 SEC16A 9919
Affinity Capture-MS Homo sapiens
14 PHC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 COMMD1 150684
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COMMD3-BMI1 is involved
PathwayEvidenceSource
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Oxidative Stress Induced Senescence TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA methylation proteins IEA Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of transcription cofactors TAS Reactome
Transcriptional Regulation by E2F6 TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here