Gene description for HMGN5
Gene name high mobility group nucleosome binding domain 5
Gene symbol HMGN5
Other names/aliases NBP-45
NSBP1
Species Homo sapiens
 Database cross references - HMGN5
ExoCarta ExoCarta_79366
Vesiclepedia VP_79366
Entrez Gene 79366
HGNC 8013
MIM 300385
UniProt P82970  
 HMGN5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HMGN5
Molecular Function
    chromatin binding GO:0003682 NAS
    RNA binding GO:0003723 HDA
    nucleosomal DNA binding GO:0031492 IEA
Biological Process
    chromatin organization GO:0006325 IEA
    regulation of DNA-templated transcription GO:0006355 NAS
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of DNA-templated transcription GO:0045893 NAS
Subcellular Localization
    chromatin GO:0000785 IEA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified HMGN5 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HMGN5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 XPC  
Affinity Capture-MS Homo sapiens
2 MCM7 4176
Affinity Capture-MS Homo sapiens
3 CBX1 10951
Affinity Capture-MS Homo sapiens
4 ARHGEF19  
Affinity Capture-MS Homo sapiens
5 FGD2 221472
Affinity Capture-MS Homo sapiens
6 TOP2B 7155
Affinity Capture-MS Homo sapiens
7 PSMD11 5717
Affinity Capture-MS Homo sapiens
8 FGD1  
Affinity Capture-MS Homo sapiens
9 POGZ 23126
Affinity Capture-MS Homo sapiens
10 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
11 SMARCE1 6605
Affinity Capture-MS Homo sapiens
12 CCT4 10575
Affinity Capture-MS Homo sapiens
13 BASP1 10409
Co-fractionation Homo sapiens
14 INCENP 3619
Affinity Capture-MS Homo sapiens
15 ATG13 9776
Affinity Capture-MS Homo sapiens
16 KAT7  
Affinity Capture-MS Homo sapiens
17 XRCC1 7515
Affinity Capture-MS Homo sapiens
18 TOP2A 7153
Affinity Capture-MS Homo sapiens
19 MBIP  
Affinity Capture-MS Homo sapiens
20 SRCAP  
Affinity Capture-MS Homo sapiens
21 RSBN1L  
Affinity Capture-MS Homo sapiens
22 MTF2  
Affinity Capture-MS Homo sapiens
23 HSPA2 3306
Affinity Capture-MS Homo sapiens
24 MCM2 4171
Affinity Capture-MS Homo sapiens
25 DDB1 1642
Affinity Capture-MS Homo sapiens
26 H1FX 8971
Affinity Capture-MS Homo sapiens
27 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
28 SMARCA1 6594
Affinity Capture-MS Homo sapiens
29 HIST2H3A 333932
Affinity Capture-MS Homo sapiens
30 HGS 9146
Affinity Capture-MS Homo sapiens
31 SUV39H1  
Affinity Capture-MS Homo sapiens
32 PSMD12 5718
Affinity Capture-MS Homo sapiens
33 PHF14 9678
Affinity Capture-MS Homo sapiens
34 PSMC6 5706
Affinity Capture-MS Homo sapiens
35 MCM6 4175
Affinity Capture-MS Homo sapiens
36 NEDD8-MDP1 100528064
Affinity Capture-MS Homo sapiens
37 SMCHD1 23347
Affinity Capture-MS Homo sapiens
38 RCC1 1104
Affinity Capture-MS Homo sapiens
39 EED  
Affinity Capture-MS Homo sapiens
40 KMT2A  
Affinity Capture-MS Homo sapiens
41 HP1BP3 50809
Affinity Capture-MS Homo sapiens
42 KLHL20  
Affinity Capture-MS Homo sapiens
43 WIZ 58525
Affinity Capture-MS Homo sapiens
44 H2AFY2 55506
Affinity Capture-MS Homo sapiens
45 SNX27 81609
Affinity Capture-MS Homo sapiens
46 RAD50 10111
Affinity Capture-MS Homo sapiens
47 UBQLN4 56893
Affinity Capture-MS Homo sapiens
48 PSMC3 5702
Affinity Capture-MS Homo sapiens
49 FEN1 2237
Affinity Capture-MS Homo sapiens
50 LCOR 84458
Affinity Capture-MS Homo sapiens
51 BRPF1  
Affinity Capture-MS Homo sapiens
52 TCP1 6950
Affinity Capture-MS Homo sapiens
53 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
54 MRE11A 4361
Affinity Capture-MS Homo sapiens
55 WHSC1 7468
Affinity Capture-MS Homo sapiens
56 RRP9 9136
Co-fractionation Homo sapiens
57 NAA40  
Affinity Capture-MS Homo sapiens
58 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
59 CBX3 11335
Affinity Capture-MS Homo sapiens
60 ATAD2 29028
Affinity Capture-MS Homo sapiens
61 PRDM2  
Affinity Capture-MS Homo sapiens
62 BARD1 580
Affinity Capture-MS Homo sapiens
63 KDM5B  
Affinity Capture-MS Homo sapiens
64 RPL36 25873
Cross-Linking-MS (XL-MS) Homo sapiens
65 BANF1 8815
Affinity Capture-MS Homo sapiens
66 SCAF11  
Affinity Capture-MS Homo sapiens
67 SMC1A 8243
Affinity Capture-MS Homo sapiens
68 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
70 POLB 5423
Affinity Capture-MS Homo sapiens
71 ZC3H15 55854
Co-fractionation Homo sapiens
72 RAD21 5885
Affinity Capture-MS Homo sapiens
73 BRCA1 672
Affinity Capture-MS Homo sapiens
74 POLR2B 5431
Affinity Capture-MS Homo sapiens
75 ZMYM4  
Affinity Capture-MS Homo sapiens
76 BRD7  
Affinity Capture-MS Homo sapiens
77 NUMA1 4926
Affinity Capture-MS Homo sapiens
78 CHRAC1  
Affinity Capture-MS Homo sapiens
79 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
80 ACLY 47
Affinity Capture-MS Homo sapiens
81 ATAD2B 54454
Affinity Capture-MS Homo sapiens
82 FBXO28  
Affinity Capture-MS Homo sapiens
83 BAZ1B 9031
Affinity Capture-MS Homo sapiens
84 SMARCA5 8467
Affinity Capture-MS Homo sapiens
85 POLR2E 5434
Affinity Capture-MS Homo sapiens
86 PHIP 55023
Affinity Capture-MS Homo sapiens
87 CYP1A1  
Affinity Capture-MS Homo sapiens
88 H1F0 3005
Affinity Capture-MS Homo sapiens
89 MCM4 4173
Affinity Capture-MS Homo sapiens
90 CBX2  
Affinity Capture-MS Homo sapiens
91 MDC1  
Affinity Capture-MS Homo sapiens
92 PSMD7 5713
Affinity Capture-MS Homo sapiens
93 SUZ12  
Affinity Capture-MS Homo sapiens
94 NTHL1  
Affinity Capture-MS Homo sapiens
95 PPHLN1  
Affinity Capture-MS Homo sapiens
96 ZNF512  
Affinity Capture-MS Homo sapiens
97 NCAPH 23397
Affinity Capture-MS Homo sapiens
98 USP47 55031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 FAM91A1 157769
Affinity Capture-MS Homo sapiens
100 ING5  
Affinity Capture-MS Homo sapiens
101 RPL35A 6165
Affinity Capture-MS Homo sapiens
102 NIPBL 25836
Affinity Capture-MS Homo sapiens
103 RAI1 10743
Affinity Capture-MS Homo sapiens
104 BAZ1A 11177
Affinity Capture-MS Homo sapiens
105 SCAPER  
Affinity Capture-MS Homo sapiens
106 RBBP5 5929
Affinity Capture-MS Homo sapiens
107 POLR2A 5430
Affinity Capture-MS Homo sapiens
108 XRCC5 7520
Affinity Capture-MS Homo sapiens
109 RBBP4 5928
Affinity Capture-MS Homo sapiens
110 C3orf17  
Affinity Capture-MS Homo sapiens
111 RPS27A 6233
Affinity Capture-MS Homo sapiens
112 GLUD1 2746
Affinity Capture-MS Homo sapiens
113 FASN 2194
Affinity Capture-MS Homo sapiens
114 KIF22  
Affinity Capture-MS Homo sapiens
115 CCT8 10694
Affinity Capture-MS Homo sapiens
116 PARP1 142
Affinity Capture-MS Homo sapiens
117 LIG3 3980
Affinity Capture-MS Homo sapiens
118 C11orf58  
Co-fractionation Homo sapiens
119 PSAT1 29968
Affinity Capture-MS Homo sapiens
120 MTA1 9112
Affinity Capture-MS Homo sapiens
121 CHAMP1  
Affinity Capture-MS Homo sapiens
122 HSPB1 3315
Co-fractionation Homo sapiens
123 PTPN2 5771
Affinity Capture-MS Homo sapiens
124 CCT7 10574
Affinity Capture-MS Homo sapiens
125 PARP2  
Affinity Capture-MS Homo sapiens
126 ZNF280C  
Affinity Capture-MS Homo sapiens
127 TRIP12 9320
Affinity Capture-MS Homo sapiens
128 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
129 KDM1A 23028
Affinity Capture-MS Homo sapiens
130 WNK3  
Affinity Capture-MS Homo sapiens
131 EZH2  
Affinity Capture-MS Homo sapiens
132 WDR76  
Affinity Capture-MS Homo sapiens
133 CAD 790
Affinity Capture-MS Homo sapiens
134 CBX8 57332
Affinity Capture-MS Homo sapiens
135 BRD1 23774
Affinity Capture-MS Homo sapiens
136 GLYR1 84656
Affinity Capture-MS Homo sapiens
137 INTS3 65123
Affinity Capture-MS Homo sapiens
138 KAT6A  
Affinity Capture-MS Homo sapiens
139 PWWP2A  
Affinity Capture-MS Homo sapiens
140 RCOR1  
Affinity Capture-MS Homo sapiens
141 CUL4A 8451
Affinity Capture-MS Homo sapiens
142 GTF2E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HMGN5 is involved
No pathways found





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