Gene description for BRCA1
Gene name	breast cancer 1, early onset
Gene symbol	BRCA1
Other names/aliases	BRCAI BRCC1 BROVCA1 FANCS IRIS PNCA4 PPP1R53 PSCP RNF53
Species	Homo sapiens
Database cross references - BRCA1
ExoCarta	ExoCarta_672
Vesiclepedia	VP_672
Entrez Gene	672
HGNC	1100
MIM	113705
UniProt	P38398
BRCA1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for BRCA1

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     DNA-binding transcription activator activity GO:0001216 IEA     p53 binding GO:0002039 IDA     DNA binding GO:0003677 TAS     damaged DNA binding GO:0003684 IEA     transcription coactivator activity GO:0003713 IDA     transcription coactivator activity GO:0003713 IMP     RNA binding GO:0003723 IDA     ubiquitin-protein transferase activity GO:0004842 IBA     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin-protein transferase activity GO:0004842 TAS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     tubulin binding GO:0015631 NAS     enzyme binding GO:0019899 IPI     ubiquitin protein ligase binding GO:0031625 IPI     identical protein binding GO:0042802 IPI     ubiquitin-modified histone reader activity GO:0061649 TAS     RNA polymerase binding GO:0070063 IDA     histone H2AK127 ubiquitin ligase activity GO:0140863 TAS     histone H2AK129 ubiquitin ligase activity GO:0140864 TAS Biological Process     double-strand break repair via homologous recombination GO:0000724 IBA     double-strand break repair via homologous recombination GO:0000724 IDA     DNA repair GO:0006281 NAS     regulation of DNA repair GO:0006282 NAS     postreplication repair GO:0006301 IDA     double-strand break repair GO:0006302 IDA     double-strand break repair GO:0006302 IMP     double-strand break repair GO:0006302 TAS     chromatin remodeling GO:0006338 TAS     regulation of transcription by RNA polymerase II GO:0006357 IMP     fatty acid biosynthetic process GO:0006633 IEA     DNA damage response GO:0006974 NAS     chromosome segregation GO:0007059 IMP     mitotic G2 DNA damage checkpoint signaling GO:0007095 IBA     mitotic G2 DNA damage checkpoint signaling GO:0007095 IMP     centrosome cycle GO:0007098 IEA     sex-chromosome dosage compensation GO:0007549 IBA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IDA     response to ionizing radiation GO:0010212 IMP     positive regulation of vascular endothelial growth factor production GO:0010575 IMP     positive regulation of gene expression GO:0010628 IMP     protein ubiquitination GO:0016567 IDA     negative regulation of cell growth GO:0030308 IMP     negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IMP     homologous recombination GO:0035825 NAS     chordate embryonic development GO:0043009 IBA     negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 IMP     mitotic G2/M transition checkpoint GO:0044818 NAS     negative regulation of fatty acid biosynthetic process GO:0045717 IMP     positive regulation of DNA repair GO:0045739 IMP     positive regulation of angiogenesis GO:0045766 IMP     negative regulation of cell cycle GO:0045786 NAS     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     negative regulation of centriole replication GO:0046600 NAS     regulation of cell cycle GO:0051726 IDA     protein autoubiquitination GO:0051865 IDA     random inactivation of X chromosome GO:0060816 IEA     cellular response to tumor necrosis factor GO:0071356 IMP     cellular response to ionizing radiation GO:0071479 IMP     cellular response to indole-3-methanol GO:0071681 IDA     protein K6-linked ubiquitination GO:0085020 IDA     DNA strand resection involved in replication fork processing GO:0110025 NAS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IMP     regulation of DNA damage checkpoint GO:2000001 NAS     negative regulation of reactive oxygen species metabolic process GO:2000378 IMP Subcellular Localization     ubiquitin ligase complex GO:0000151 NAS     nuclear ubiquitin ligase complex GO:0000152 IDA     lateral element GO:0000800 IDA     gamma-tubulin ring complex GO:0000931 NAS     male germ cell nucleus GO:0001673 IEA     XY body GO:0001741 IEA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     chromosome GO:0005694 ISS     cytoplasm GO:0005737 IDA     plasma membrane GO:0005886 IDA     nuclear body GO:0016604 IDA     BRCA1-BARD1 complex GO:0031436 IBA     BRCA1-BARD1 complex GO:0031436 IDA     BRCA1-BARD1 complex GO:0031436 IPI     protein-containing complex GO:0032991 IDA     intracellular membraneless organelle GO:0043232 IDA     BRCA1-A complex GO:0070531 IBA     BRCA1-A complex GO:0070531 IDA     BRCA1-A complex GO:0070531 NAS     BRCA1-B complex GO:0070532 IPI     BRCA1-C complex GO:0070533 IPI     DNA repair complex GO:1990391 IPI     ribonucleoprotein complex GO:1990904 IDA