Gene description for KPNA2
Gene name karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Gene symbol KPNA2
Other names/aliases IPOA1
QIP2
RCH1
SRP1alpha
Species Homo sapiens
 Database cross references - KPNA2
ExoCarta ExoCarta_3838
Vesiclepedia VP_3838
Entrez Gene 3838
HGNC 6395
MIM 600685
UniProt P52292  
 KPNA2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
 Gene ontology annotations for KPNA2
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    nuclear localization sequence binding GO:0008139 IBA
    nuclear localization sequence binding GO:0008139 IDA
    histone deacetylase binding GO:0042826 IPI
    nuclear import signal receptor activity GO:0061608 IBA
    nuclear import signal receptor activity GO:0061608 IDA
Biological Process
    regulation of DNA recombination GO:0000018 TAS
    DNA metabolic process GO:0006259 TAS
    protein import into nucleus GO:0006606 IDA
    protein import into nucleus GO:0006606 ISS
    NLS-bearing protein import into nucleus GO:0006607 IBA
    NLS-bearing protein import into nucleus GO:0006607 IDA
    positive regulation of type I interferon production GO:0032481 IDA
    entry of viral genome into host nucleus through nuclear pore complex via importin GO:0075506 IMP
    positive regulation of viral life cycle GO:1903902 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 NAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 NAS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IDA
    NLS-dependent protein nuclear import complex GO:0042564 IPI
    host cell GO:0043657 IEA
 Experiment description of studies that identified KPNA2 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 207
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 208
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
15
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 1275
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 1280
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
25
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
26
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 257
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 258
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 259
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 260
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
32
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
33
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
36
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
42
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
44
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
46
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
47
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for KPNA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDCA2 157313
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 HDAC2 3066
Affinity Capture-MS Homo sapiens
4 UBL4A 8266
Affinity Capture-MS Homo sapiens
5 RBPMS 11030
Two-hybrid Homo sapiens
6 KPNA1 3836
Co-fractionation Homo sapiens
7 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
8 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
9 ACTC1 70
Affinity Capture-MS Homo sapiens
10 UBA1 7317
Affinity Capture-MS Homo sapiens
11 BRCA1 672
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 NMNAT1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 SMARCE1 6605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KIF20A 10112
Affinity Capture-MS Homo sapiens
15 ZC3H12A  
Two-hybrid Homo sapiens
16 CSE1L 1434
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
17 SMARCD2 6603
Affinity Capture-MS Homo sapiens
18 TAF8  
Reconstituted Complex Homo sapiens
19 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
20 DPM1 8813
Cross-Linking-MS (XL-MS) Homo sapiens
21 KIF23 9493
Affinity Capture-MS Homo sapiens
22 CTDSPL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SF3B1 23451
Co-fractionation Homo sapiens
24 NUP153 9972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 POLR3G  
Affinity Capture-MS Homo sapiens
26 MORF4L1  
Two-hybrid Homo sapiens
27 POU5F1  
Affinity Capture-MS Homo sapiens
28 SMC2 10592
Co-fractionation Homo sapiens
29 BOD1L1 259282
Affinity Capture-MS Homo sapiens
30 Nhp2l1 20826
Affinity Capture-MS Mus musculus
31 MECP2 4204
Affinity Capture-MS Homo sapiens
32 MTA2 9219
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
33 KIF14 9928
Affinity Capture-MS Homo sapiens
34 ANKIB1 54467
Two-hybrid Homo sapiens
35 CHMP4C 92421
Affinity Capture-MS Homo sapiens
36 KIFC1 3833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ARHGEF39 84904
Affinity Capture-MS Homo sapiens
38 USP11 8237
Affinity Capture-MS Homo sapiens
39 MEPCE 56257
Affinity Capture-MS Homo sapiens
40 SAE1 10055
Affinity Capture-MS Homo sapiens
41 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
42 PNMA5 114824
Two-hybrid Homo sapiens
43 CARM1 10498
Affinity Capture-MS Homo sapiens
44 MYH9 4627
Co-fractionation Homo sapiens
45 ACTN4 81
Two-hybrid Homo sapiens
46 SLX4  
Affinity Capture-MS Homo sapiens
47 CBX5 23468
Affinity Capture-MS Homo sapiens
48 Mki67 17345
Affinity Capture-MS Mus musculus
49 HECTD1 25831
Affinity Capture-MS Homo sapiens
50 MAGEH1  
Two-hybrid Homo sapiens
51 SRPK1 6732
Biochemical Activity Homo sapiens
52 CD3EAP  
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
53 ANLN 54443
Affinity Capture-MS Homo sapiens
54 BRD7  
Affinity Capture-MS Homo sapiens
55 Strn3  
Affinity Capture-MS Mus musculus
56 NASP 4678
Co-fractionation Homo sapiens
57 MTIF2 4528
Co-fractionation Homo sapiens
58 LMNB1 4001
Affinity Capture-MS Homo sapiens
59 Sart3  
Affinity Capture-MS Mus musculus
60 ASS1 445
Co-fractionation Homo sapiens
61 TDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DCPS 28960
Two-hybrid Homo sapiens
63 RBBP4 5928
Affinity Capture-MS Homo sapiens
64 FN1 2335
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
65 PRMT5 10419
Co-fractionation Homo sapiens
66 RPA3 6119
Proximity Label-MS Homo sapiens
67 CREB3L3  
Two-hybrid Homo sapiens
68 SPRY1 10252
Two-hybrid Homo sapiens
69 RELA 5970
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
70 TANK 10010
Two-hybrid Homo sapiens
71 ARID2  
Affinity Capture-MS Homo sapiens
72 GRB2 2885
Two-hybrid Homo sapiens
73 RGL2 5863
Two-hybrid Homo sapiens
74 USP1 7398
Affinity Capture-MS Homo sapiens
75 RGPD8  
Affinity Capture-MS Homo sapiens
76 RUVBL2 10856
Affinity Capture-MS Homo sapiens
77 KPNA6 23633
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
78 NGEF  
Affinity Capture-MS Homo sapiens
79 SOS2 6655
Affinity Capture-MS Homo sapiens
80 MORF4L2  
Affinity Capture-MS Homo sapiens
81 DCTN2 10540
Two-hybrid Homo sapiens
82 SIRT1  
Affinity Capture-MS Homo sapiens
83 ARHGAP36  
Affinity Capture-MS Homo sapiens
84 LDLR 3949
Negative Genetic Homo sapiens
85 SNW1 22938
Affinity Capture-MS Homo sapiens
86 POLR1D 51082
Affinity Capture-MS Homo sapiens
87 PTCH1  
Affinity Capture-MS Homo sapiens
88 TRAF1 7185
Two-hybrid Homo sapiens
89 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
90 NCBP1 4686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 SPRTN  
Affinity Capture-MS Homo sapiens
92 GART 2618
Two-hybrid Homo sapiens
93 TARDBP 23435
Affinity Capture-MS Homo sapiens
94 NUP62 23636
Two-hybrid Homo sapiens
95 RNMT 8731
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
96 HSP90AB1 3326
Co-fractionation Homo sapiens
97 CAND1 55832
Affinity Capture-MS Homo sapiens
98 ACTN1 87
Two-hybrid Homo sapiens
99 SYDE2  
Affinity Capture-MS Homo sapiens
100 Pcyt1a  
Affinity Capture-Western Mus musculus
101 CORO1B 57175
Two-hybrid Homo sapiens
102 KIF22  
Affinity Capture-MS Homo sapiens
103 NOLC1 9221
Affinity Capture-MS Homo sapiens
104 PRC1 9055
Affinity Capture-MS Homo sapiens
105 OBSL1 23363
Affinity Capture-MS Homo sapiens
106 VCAM1 7412
Affinity Capture-MS Homo sapiens
107 CUL1 8454
Affinity Capture-MS Homo sapiens
108 SETD1A 9739
Affinity Capture-MS Homo sapiens
109 PHF10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 MAPK3 5595
Co-fractionation Homo sapiens
111 NCBP2 22916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 DDX21 9188
Affinity Capture-MS Homo sapiens
113 KLC4 89953
Two-hybrid Homo sapiens
114 RECQL 5965
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
115 BAG6 7917
Reconstituted Complex Homo sapiens
116 POLR3F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 ARL4A  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
118 RAG1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
119 NELFE 7936
Affinity Capture-MS Homo sapiens
120 PMAIP1  
Affinity Capture-MS Homo sapiens
121 BCL7C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 RAD18  
Affinity Capture-MS Homo sapiens
123 LYAR 55646
Affinity Capture-MS Homo sapiens
124 PPM1G 5496
Affinity Capture-MS Homo sapiens
125 Ksr1  
Affinity Capture-MS Mus musculus
126 RAD21 5885
Co-fractionation Homo sapiens
127 ACLY 47
Co-fractionation Homo sapiens
128 CANX 821
Co-fractionation Homo sapiens
129 XPO1 7514
Affinity Capture-MS Homo sapiens
130 RC3H2  
Affinity Capture-MS Homo sapiens
131 IKZF3  
Affinity Capture-MS Homo sapiens
132 POLR2E 5434
Affinity Capture-MS Homo sapiens
133 FUS 2521
Affinity Capture-MS Homo sapiens
134 TMEM194A  
Affinity Capture-MS Homo sapiens
135 FTH1 2495
Two-hybrid Homo sapiens
136 IKZF1  
Affinity Capture-MS Homo sapiens
137 CDK2 1017
Affinity Capture-MS Homo sapiens
138 TADA2A  
Two-hybrid Homo sapiens
139 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
140 BAG1 573
Affinity Capture-MS Homo sapiens
141 Sept6  
Affinity Capture-MS Mus musculus
142 NPIPB6  
Affinity Capture-MS Homo sapiens
143 SART3 9733
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
144 SAP25  
Affinity Capture-MS Homo sapiens
145 CUL7 9820
Affinity Capture-MS Homo sapiens
146 DDRGK1 65992
Affinity Capture-MS Homo sapiens
147 BMI1  
Affinity Capture-MS Homo sapiens
148 APOBEC1  
Two-hybrid Homo sapiens
149 HMG20A  
Two-hybrid Homo sapiens
150 HUWE1 10075
Affinity Capture-MS Homo sapiens
151 GATAD2A 54815
Affinity Capture-MS Homo sapiens
152 KRT18 3875
Two-hybrid Homo sapiens
153 PRKCSH 5589
Co-fractionation Homo sapiens
154 POLR2F  
Affinity Capture-MS Homo sapiens
155 SGK1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
156 HDGF 3068
Affinity Capture-MS Homo sapiens
157 HOMEZ  
Two-hybrid Homo sapiens
158 PSME3 10197
Affinity Capture-MS Homo sapiens
159 ESR1  
Affinity Capture-MS Homo sapiens
160 Arhgap6  
Affinity Capture-MS Mus musculus
161 Ranbp2  
Affinity Capture-MS Mus musculus
162 KRAS 3845
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
163 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
164 IKBKB 3551
Co-fractionation Homo sapiens
165 PRMT1 3276
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
166 RANBP2 5903
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
167 MVP 9961
Two-hybrid Homo sapiens
168 GTF2F1 2962
Affinity Capture-MS Homo sapiens
169 HNRNPC 3183
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
170 CBX1 10951
Affinity Capture-MS Homo sapiens
171 NOP58 51602
Affinity Capture-MS Homo sapiens
172 PMS1  
Affinity Capture-Western Homo sapiens
173 PTMA 5757
Co-purification Homo sapiens
174 RNF4 6047
Affinity Capture-MS Homo sapiens
175 DNAJA4 55466
Co-fractionation Homo sapiens
176 SDAD1  
Affinity Capture-MS Homo sapiens
177 MDFI  
Two-hybrid Homo sapiens
178 SSB 6741
Affinity Capture-MS Homo sapiens
179 CHEK2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
180 TRIM54  
Two-hybrid Homo sapiens
181 INTS9 55756
Affinity Capture-MS Homo sapiens
182 LRPPRC 10128
Co-fractionation Homo sapiens
183 CAPZB 832
Affinity Capture-MS Homo sapiens
184 ZBTB33  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
185 Ddb1 13194
Affinity Capture-MS Mus musculus
186 MCM2 4171
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
187 KPNA3 3839
Co-fractionation Homo sapiens
188 SPAG9 9043
Co-fractionation Homo sapiens
189 KRT40  
Two-hybrid Homo sapiens
190 Pax5  
Two-hybrid Mus musculus
191 POLR1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 SMAD6  
Affinity Capture-MS Homo sapiens
193 ITGA4 3676
Affinity Capture-MS Homo sapiens
194 GPN1  
Affinity Capture-MS Homo sapiens
195 SMARCA2 6595
Affinity Capture-MS Homo sapiens
196 IFT20 90410
Two-hybrid Homo sapiens
197 FAS 355
Proximity Label-MS Homo sapiens
198 POLR2K  
Affinity Capture-MS Homo sapiens
199 NUP155 9631
Proximity Label-MS Homo sapiens
200 PPM1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 NF2 4771
Affinity Capture-MS Homo sapiens
202 IPO7 10527
Affinity Capture-MS Homo sapiens
203 KPNA4 3840
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
204 TAF10 6881
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
205 PARK2  
Affinity Capture-MS Homo sapiens
206 PHAX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 FAM204A  
Affinity Capture-MS Homo sapiens
208 SRRT 51593
Affinity Capture-MS Homo sapiens
209 ACOT13  
Co-fractionation Homo sapiens
210 CHMP4B 128866
Affinity Capture-MS Homo sapiens
211 SLC2A2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
212 RAN 5901
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
213 NTRK1 4914
Affinity Capture-MS Homo sapiens
214 ZNF131  
Reconstituted Complex Homo sapiens
215 PLAG1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
216 Ncbp2  
Affinity Capture-MS Mus musculus
217 CA9 768
Affinity Capture-MS Homo sapiens
218 OGT 8473
Reconstituted Complex Homo sapiens
219 ZBTB2 57621
Affinity Capture-MS Homo sapiens
220 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 ECT2 1894
Affinity Capture-MS Homo sapiens
222 HN1 51155
Co-fractionation Homo sapiens
223 CCDC107  
Two-hybrid Homo sapiens
224 C12orf45  
Affinity Capture-MS Homo sapiens
225 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
226 SYDE1 85360
Affinity Capture-MS Homo sapiens
227 PRPF19 27339
Affinity Capture-Western Homo sapiens
228 TERF2  
Affinity Capture-MS Homo sapiens
229 EPB41 2035
Reconstituted Complex Homo sapiens
230 MATR3 9782
Co-fractionation Homo sapiens
231 GMCL1  
Two-hybrid Homo sapiens
232 RHOB 388
Proximity Label-MS Homo sapiens
233 RBBP5 5929
Affinity Capture-MS Homo sapiens
234 IMMT 10989
Two-hybrid Homo sapiens
235 NUTM1  
Two-hybrid Homo sapiens
236 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
237 PHB2 11331
Affinity Capture-Western Homo sapiens
238 FBXL6  
Affinity Capture-MS Homo sapiens
239 FBXW11  
Affinity Capture-MS Homo sapiens
240 POLR3C 10623
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 USP36  
Affinity Capture-MS Homo sapiens
242 AICDA  
Affinity Capture-Western Homo sapiens
243 PBRM1 55193
Affinity Capture-MS Homo sapiens
244 Kifc5b  
Affinity Capture-MS Mus musculus
245 CREBBP  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
246 MORC3 23515
Two-hybrid Homo sapiens
247 KIFAP3 22920
Affinity Capture-MS Homo sapiens
248 CUL4B 8450
Reconstituted Complex Homo sapiens
249 PCNA 5111
Co-fractionation Homo sapiens
250 UFL1 23376
Affinity Capture-MS Homo sapiens
251 DDIT3 1649
Two-hybrid Homo sapiens
252 PDIK1L  
Affinity Capture-MS Homo sapiens
253 LAMB2 3913
Two-hybrid Homo sapiens
254 SERBP1 26135
Affinity Capture-MS Homo sapiens
255 AR 367
Affinity Capture-MS Homo sapiens
256 RAC1 5879
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
257 RC3H1 149041
Affinity Capture-MS Homo sapiens
258 COPS4 51138
Co-fractionation Homo sapiens
259 VIM 7431
Co-fractionation Homo sapiens
260 CDK11A 728642
Affinity Capture-MS Homo sapiens
261 EP300 2033
Biochemical Activity Homo sapiens
262 UBE2H 7328
Affinity Capture-MS Homo sapiens
263 RNGTT 8732
Affinity Capture-MS Homo sapiens
264 SLFN11 91607
Affinity Capture-MS Homo sapiens
265 AP2B1 163
Two-hybrid Homo sapiens
266 NECAB2  
Two-hybrid Homo sapiens
267 COIL  
Proximity Label-MS Homo sapiens
268 PPIE 10450
Affinity Capture-MS Homo sapiens
269 TNPO1 3842
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
270 KPNB1 3837
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
271 CTNNBL1 56259
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
272 TAF3 83860
Reconstituted Complex Homo sapiens
273 POM121  
Affinity Capture-MS Homo sapiens
274 MLH1 4292
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
275 APP 351
Reconstituted Complex Homo sapiens
276 GSK3A 2931
Affinity Capture-MS Homo sapiens
277 PPP1CC 5501
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
278 KIAA1429 25962
Affinity Capture-MS Homo sapiens
279 EIF4ENIF1 56478
Two-hybrid Homo sapiens
280 TSC22D4 81628
Two-hybrid Homo sapiens
281 BCL7B  
Affinity Capture-MS Homo sapiens
282 COPS5 10987
Affinity Capture-MS Homo sapiens
283 SLC27A2 11001
Affinity Capture-MS Homo sapiens
284 Dock11  
Affinity Capture-MS Mus musculus
285 INO80E  
Two-hybrid Homo sapiens
286 CDT1  
Affinity Capture-MS Homo sapiens
287 ASH2L 9070
Affinity Capture-MS Homo sapiens
288 PMS2  
Affinity Capture-MS Homo sapiens
289 Zbtb33  
Reconstituted Complex Mus musculus
290 RAB39B 116442
Affinity Capture-MS Homo sapiens
291 MYCN  
Affinity Capture-MS Homo sapiens
292 SMARCB1 6598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
293 ARHGAP9 64333
Affinity Capture-MS Homo sapiens
294 CTCF  
Affinity Capture-MS Homo sapiens
295 POLR1A 25885
Co-fractionation Homo sapiens
296 KRT8 3856
Two-hybrid Homo sapiens
297 POM121C  
Affinity Capture-MS Homo sapiens
298 Rcc1  
Affinity Capture-MS Mus musculus
299 NUP50 10762
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
300 SMARCA4 6597
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
301 RILP 83547
Two-hybrid Homo sapiens
302 IFI16 3428
Affinity Capture-MS Homo sapiens
303 MYH10 4628
Co-fractionation Homo sapiens
304 ITK 3702
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
305 IDH3G 3421
Co-fractionation Homo sapiens
306 MBD3 53615
Affinity Capture-MS Homo sapiens
307 Ube2i  
Two-hybrid Mus musculus
308 ITCH 83737
Affinity Capture-MS Homo sapiens
309 PRPF31 26121
Affinity Capture-Western Homo sapiens
310 FEZ2 9637
Two-hybrid Homo sapiens
311 SMARCC2 6601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
312 HAP1  
Two-hybrid Homo sapiens
313 NUMA1 4926
Affinity Capture-MS Homo sapiens
314 FGD5  
Affinity Capture-MS Homo sapiens
315 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
316 CDK9 1025
Affinity Capture-MS Homo sapiens
317 POLR2H 5437
Affinity Capture-MS Homo sapiens
318 CLK3  
Affinity Capture-MS Homo sapiens
319 OTUD1 220213
Affinity Capture-MS Homo sapiens
320 Kifc1  
Affinity Capture-MS Mus musculus
321 PLRG1 5356
Affinity Capture-Western Homo sapiens
322 2700060E02Rik 68045
Two-hybrid Mus musculus
323 MRGBP  
Affinity Capture-MS Homo sapiens
324 MCM4 4173
Co-fractionation Homo sapiens
325 BAP1 8314
Protein-peptide Homo sapiens
326 SART1 9092
Co-fractionation Homo sapiens
327 NXF1 10482
Affinity Capture-RNA Homo sapiens
328 PRKCI 5584
Co-fractionation Homo sapiens
329 JUN 3725
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
330 LZTS2 84445
Two-hybrid Homo sapiens
331 ARHGAP22 58504
Affinity Capture-MS Homo sapiens
332 HOMER2  
Two-hybrid Homo sapiens
333 RGPD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
334 NFKB1 4790
Co-fractionation Homo sapiens
335 ZBTB7B  
Two-hybrid Homo sapiens
336 SRSF10 10772
Co-fractionation Homo sapiens
337 CHD8 57680
Affinity Capture-MS Homo sapiens
338 USHBP1  
Two-hybrid Homo sapiens
339 CCDC8  
Affinity Capture-MS Homo sapiens
340 SIRT6  
Affinity Capture-MS Homo sapiens
341 ARL5A 26225
Reconstituted Complex Homo sapiens
342 POLR1C 9533
Affinity Capture-MS Homo sapiens
343 SMARCC1 6599
Affinity Capture-MS Homo sapiens
344 TBPL2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
345 HDAC1 3065
Affinity Capture-MS Homo sapiens
346 BTBD2  
Two-hybrid Homo sapiens
347 TERF1 7013
Affinity Capture-MS Homo sapiens
348 ING1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
349 MAGED1 9500
Two-hybrid Homo sapiens
350 KIF18B 146909
Affinity Capture-MS Homo sapiens
351 SREK1IP1  
Affinity Capture-MS Homo sapiens
352 TRIM31  
Affinity Capture-MS Homo sapiens
353 RELB  
Affinity Capture-MS Homo sapiens
354 CDK5RAP3 80279
Two-hybrid Homo sapiens
355 HNRNPU 3192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
356 C9orf72  
Affinity Capture-MS Homo sapiens
357 SMARCD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
358 WARS 7453
Co-fractionation Homo sapiens
359 ANKRD54  
Affinity Capture-MS Homo sapiens
360 WDHD1  
Co-fractionation Homo sapiens
361 SERTAD3  
Two-hybrid Homo sapiens
362 NEDD8 4738
Affinity Capture-MS Homo sapiens
363 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KPNA2 is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Ca-dependent events IEA Reactome
Calmodulin induced events IEA Reactome
CaM pathway IEA Reactome
CaMK IV-mediated phosphorylation of CREB IEA Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
DAG and IP3 signaling IEA Reactome
Disease TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
G alpha (i) signalling events IEA Reactome
G-protein mediated events IEA Reactome
GPCR downstream signalling IEA Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Interferon Signaling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
ISG15 antiviral mechanism TAS Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
NS1 Mediated Effects on Host Pathways TAS Reactome
Opioid Signalling IEA Reactome
PLC beta mediated events IEA Reactome
Post NMDA receptor activation events IEA Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 activates/modulates innate immune responses TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Sensing of DNA Double Strand Breaks TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Transmission across Chemical Synapses IEA Reactome
Viral Infection Pathways TAS Reactome





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