Gene description for CDK11A
Gene name cyclin-dependent kinase 11A
Gene symbol CDK11A
Other names/aliases CDC2L2
CDC2L3
CDK11-p110
CDK11-p46
CDK11-p58
PITSLRE
p58GTA
Species Homo sapiens
 Database cross references - CDK11A
ExoCarta ExoCarta_728642
Vesiclepedia VP_728642
Entrez Gene 728642
HGNC 1730
MIM 116951
UniProt Q9UQ88  
 CDK11A identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CDK11A
Molecular Function
    protein kinase activity GO:0004672 NAS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    mitotic cell cycle GO:0000278 NAS
    regulation of cell growth GO:0001558 IEP
    regulation of DNA-templated transcription GO:0006355 NAS
    protein phosphorylation GO:0006468 IDA
    apoptotic process GO:0006915 NAS
    regulation of apoptotic process GO:0042981 NAS
    regulation of RNA splicing GO:0043484 IDA
    regulation of centrosome cycle GO:0046605 NAS
    regulation of mRNA processing GO:0050684 IDA
    regulation of cell cycle GO:0051726 IBA
    regulation of cell cycle GO:0051726 NAS
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IPI
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified CDK11A in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CDK11A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 ZNF267  
Affinity Capture-MS Homo sapiens
4 SENP3 26168
Affinity Capture-MS Homo sapiens
5 SERPINB4 6318
Affinity Capture-MS Homo sapiens
6 NOP58 51602
Affinity Capture-MS Homo sapiens
7 NOLC1 9221
Co-fractionation Homo sapiens
8 SPRR3 6707
Affinity Capture-MS Homo sapiens
9 COIL  
Proximity Label-MS Homo sapiens
10 SKIV2L 6499
Two-hybrid Homo sapiens
11 GADD45A  
Two-hybrid Homo sapiens
12 TRIM35 23087
Affinity Capture-MS Homo sapiens
13 KPNB1 3837
Affinity Capture-MS Homo sapiens
14 HKR1  
Affinity Capture-MS Homo sapiens
15 DHX8 1659
Proximity Label-MS Homo sapiens
16 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CSNK2A1 1457
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KPNA2 3838
Affinity Capture-MS Homo sapiens
19 PRPF40A 55660
Affinity Capture-MS Homo sapiens
20 APEX1 328
Affinity Capture-RNA Homo sapiens
Proximity Label-MS Homo sapiens
21 DDX23 9416
Proximity Label-MS Homo sapiens
22 RNPS1 10921
Affinity Capture-Western Homo sapiens
23 CDK11B 984
Affinity Capture-MS Homo sapiens
24 D2HGDH 728294
Affinity Capture-MS Homo sapiens
25 SPAG9 9043
Affinity Capture-MS Homo sapiens
26 FBXW7  
Affinity Capture-MS Homo sapiens
27 ZNF460  
Affinity Capture-MS Homo sapiens
28 POLR1E  
Proximity Label-MS Homo sapiens
29 MCM6 4175
Affinity Capture-MS Homo sapiens
30 EPS15L1 58513
Affinity Capture-MS Homo sapiens
31 B4GALT1 2683
Reconstituted Complex Homo sapiens
32 MYCN  
Affinity Capture-MS Homo sapiens
33 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 COMMD4 54939
Affinity Capture-MS Homo sapiens
35 PAK1 5058
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
36 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 DHX40  
Proximity Label-MS Homo sapiens
38 SRP9 6726
Affinity Capture-MS Homo sapiens
39 USP15 9958
Affinity Capture-MS Homo sapiens
40 DDX21 9188
Affinity Capture-MS Homo sapiens
41 C18orf25 147339
Affinity Capture-MS Homo sapiens
42 PARK2  
Affinity Capture-MS Homo sapiens
43 A2M 2
Affinity Capture-MS Homo sapiens
44 CBX3 11335
Proximity Label-MS Homo sapiens
45 LRRC29  
Affinity Capture-MS Homo sapiens
46 DPF2  
Co-fractionation Homo sapiens
47 RPL31 6160
Proximity Label-MS Homo sapiens
48 CCNL1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
49 SMAD3 4088
Affinity Capture-MS Homo sapiens
50 AP3B1 8546
Co-fractionation Homo sapiens
51 PELP1 27043
Co-fractionation Homo sapiens
52 HSPB8 26353
Affinity Capture-MS Homo sapiens
53 KDF1  
Affinity Capture-MS Homo sapiens
54 FOXK2  
Affinity Capture-MS Homo sapiens
55 LEO1 123169
Co-fractionation Homo sapiens
56 BTNL9  
Affinity Capture-MS Homo sapiens
57 LMNB1 4001
Affinity Capture-MS Homo sapiens
58 ECT2 1894
Affinity Capture-MS Homo sapiens
59 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SAP30BP  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
61 S100A7 6278
Affinity Capture-MS Homo sapiens
62 DDB2  
Affinity Capture-MS Homo sapiens
63 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 CCT3 7203
Affinity Capture-MS Homo sapiens
65 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 MCM4 4173
Affinity Capture-MS Homo sapiens
67 S100A7A 338324
Affinity Capture-MS Homo sapiens
68 METTL21B  
Affinity Capture-MS Homo sapiens
69 CCT6B 10693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ZNF510  
Affinity Capture-MS Homo sapiens
71 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CCNL2 81669
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 C12orf43  
Affinity Capture-MS Homo sapiens
76 LMNA 4000
Affinity Capture-MS Homo sapiens
77 ZFP14  
Affinity Capture-MS Homo sapiens
78 SUPT16H 11198
Co-fractionation Homo sapiens
79 WDR47  
Affinity Capture-MS Homo sapiens
80 CRNN 49860
Affinity Capture-MS Homo sapiens
81 EIF3F 8665
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
82 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
83 CTR9 9646
Co-fractionation Homo sapiens
84 PARP1 142
Proximity Label-MS Homo sapiens
85 RBM25 58517
Affinity Capture-MS Homo sapiens
86 PIN1 5300
Reconstituted Complex Homo sapiens
87 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PDHA1 5160
Affinity Capture-MS Homo sapiens
89 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 DDX58 23586
Affinity Capture-RNA Homo sapiens
91 UFL1 23376
Affinity Capture-MS Homo sapiens
92 RPS24 6229
Proximity Label-MS Homo sapiens
93 NCL 4691
Affinity Capture-MS Homo sapiens
94 EID3  
Affinity Capture-MS Homo sapiens
95 ZG16B 124220
Affinity Capture-MS Homo sapiens
96 AP4M1 9179
Affinity Capture-MS Homo sapiens
97 CIT 11113
Affinity Capture-MS Homo sapiens
98 MCM2 4171
Affinity Capture-MS Homo sapiens
99 PSMD1 5707
Affinity Capture-MS Homo sapiens
100 IVNS1ABP  
Affinity Capture-MS Homo sapiens
101 SP7  
Proximity Label-MS Homo sapiens
102 ZNF33A 7581
Affinity Capture-MS Homo sapiens
103 CDKN2A 1029
Affinity Capture-MS Homo sapiens
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