Gene description for CDC16
Gene name cell division cycle 16
Gene symbol CDC16
Other names/aliases ANAPC6
APC6
CUT9
Species Homo sapiens
 Database cross references - CDC16
ExoCarta ExoCarta_8881
Vesiclepedia VP_8881
Entrez Gene 8881
HGNC 1720
MIM 603461
UniProt Q13042  
 CDC16 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CDC16
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of mitotic cell cycle GO:0007346 NAS
    protein ubiquitination GO:0016567 IBA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IBA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IDA
    anaphase-promoting complex-dependent catabolic process GO:0031145 NAS
    positive regulation of mitotic metaphase/anaphase transition GO:0045842 IBA
    cell division GO:0051301 IBA
    regulation of meiotic cell cycle GO:0051445 NAS
    protein K48-linked ubiquitination GO:0070936 IDA
    protein K11-linked ubiquitination GO:0070979 IDA
    protein branched polyubiquitination GO:0141198 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    anaphase-promoting complex GO:0005680 IBA
    anaphase-promoting complex GO:0005680 IDA
    anaphase-promoting complex GO:0005680 IPI
    anaphase-promoting complex GO:0005680 NAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified CDC16 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CDC16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C15orf39  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 FAM208A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CDC26 246184
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 HOOK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 IZUMO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 Anapc13  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
9 ZBTB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PAXIP1  
Affinity Capture-MS Homo sapiens
11 JMJD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 BUB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
14 RABEP2 79874
Affinity Capture-MS Homo sapiens
15 DNTTIP1 116092
Affinity Capture-MS Homo sapiens
16 Nek2  
Affinity Capture-MS Mus musculus
17 ANAPC5 51433
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ANAPC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BRCA1 672
Affinity Capture-MS Homo sapiens
20 SMG7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SPSB4  
Affinity Capture-MS Homo sapiens
22 BUB1B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 Sirt2 64383
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
24 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
25 SAMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 MYO5C 55930
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RSBN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 EIF4E2  
Affinity Capture-MS Homo sapiens
29 CEP97 79598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TAF5  
Co-fractionation Homo sapiens
31 Ppp5c  
Two-hybrid Mus musculus
Two-hybrid Mus musculus
32 C9orf78 51759
Affinity Capture-MS Homo sapiens
33 LONP2 83752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NCOR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ERF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 DIAPH1 1729
Affinity Capture-MS Homo sapiens
37 ZNF408  
Affinity Capture-MS Homo sapiens
38 CFAP97  
Affinity Capture-MS Homo sapiens
39 TAF3 83860
Co-fractionation Homo sapiens
40 DHX35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TRMT44  
Affinity Capture-MS Homo sapiens
42 PLCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FAM83D 81610
Affinity Capture-MS Homo sapiens
44 FZR1  
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 B4GALT7 11285
Affinity Capture-MS Homo sapiens
46 ZNF281  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TTC26 79989
Affinity Capture-MS Homo sapiens
48 MDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
49 RECQL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SRP14 6727
Affinity Capture-MS Homo sapiens
51 ANAPC11  
Co-purification Homo sapiens
52 THRSP  
Affinity Capture-MS Homo sapiens
53 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 TUBGCP6 85378
Affinity Capture-MS Homo sapiens
55 FBXO5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ANAPC7 51434
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ZNF644  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 NAP1L4 4676
Co-fractionation Homo sapiens
59 Gm9174  
Affinity Capture-MS Mus musculus
60 YY1AP1 55249
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ANAPC16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
63 CEP131 22994
Affinity Capture-MS Homo sapiens
64 MAD2L1 4085
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
65 Cdc20  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
66 USP37  
Proximity Label-MS Homo sapiens
67 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 MTNR1B  
Two-hybrid Homo sapiens
69 RB1 5925
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
70 AURKA 6790
Affinity Capture-MS Homo sapiens
71 SRP9 6726
Affinity Capture-MS Homo sapiens
72 HAUS5 23354
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 Anapc5 59008
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
74 CDC23 8697
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PARK2  
Affinity Capture-MS Homo sapiens
76 HAUS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 KRBA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 CEP295  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 CSRP2BP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 TRIM24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 CCNB1 891
Affinity Capture-Western Homo sapiens
83 HAUS8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 SMAD3 4088
Affinity Capture-Western Homo sapiens
85 TTLL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 HAUS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 DNAJA1 3301
Two-hybrid Homo sapiens
88 CEP164  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 SMAD2 4087
Affinity Capture-Western Homo sapiens
90 PML 5371
Affinity Capture-MS Homo sapiens
91 ANAPC4 29945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 YDJC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 LATS2 26524
Affinity Capture-MS Homo sapiens
95 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 FGFR1OP  
Affinity Capture-MS Homo sapiens
97 BCOR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 KIF18A  
Affinity Capture-MS Homo sapiens
100 DISC1 27185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 NUMA1 4926
Affinity Capture-MS Homo sapiens
102 UBE2S  
Reconstituted Complex Homo sapiens
103 DDX11L8  
Affinity Capture-MS Homo sapiens
104 ANAPC13 25847
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
105 ANO6 196527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SMCR8 140775
Affinity Capture-MS Homo sapiens
107 COPS2 9318
Affinity Capture-MS Homo sapiens
108 Cdc23  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
109 SMARCAD1  
Affinity Capture-MS Homo sapiens
110 TP53BP1 7158
Affinity Capture-MS Homo sapiens
111 TRIM33 51592
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SMG8 55181
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 MGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 ANAPC10  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 IQCB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 C11orf49  
Two-hybrid Homo sapiens
117 ASPM 259266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 SNX18 112574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 CUL3 8452
Affinity Capture-MS Homo sapiens
120 RICTOR 253260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 CCP110  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 USP54 159195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 PYCR1 5831
Affinity Capture-MS Homo sapiens
124 HOOK3 84376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 H1F0 3005
Affinity Capture-MS Homo sapiens
126 FTH1 2495
Two-hybrid Homo sapiens
127 PYCR2 29920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 EIF2AK4 440275
Affinity Capture-MS Homo sapiens
129 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
130 Paxip1  
Affinity Capture-MS Mus musculus
131 Anapc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
132 Cdc16  
Affinity Capture-MS Mus musculus
133 DUS3L 56931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 RRM2 6241
Affinity Capture-MS Homo sapiens
136 CUL9  
Affinity Capture-MS Homo sapiens
137 YEATS2  
Affinity Capture-MS Homo sapiens
138 KIAA0586  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 PSPC1 55269
Affinity Capture-MS Homo sapiens
140 HECW2  
Affinity Capture-MS Homo sapiens
141 C14orf80  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 TOP1 7150
Affinity Capture-MS Homo sapiens
143 GATAD2B 57459
Affinity Capture-MS Homo sapiens
144 ZNF687  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 Anapc1  
Affinity Capture-MS Mus musculus
146 MYO9A 4649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 ALMS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 Bub1b 12236
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
149 Mad2l1 56150
Affinity Capture-MS Mus musculus
150 CEP350 9857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 HINT1 3094
Two-hybrid Homo sapiens
152 AKAP1 8165
Proximity Label-MS Homo sapiens
153 TAF4 6874
Co-fractionation Homo sapiens
154 XRCC5 7520
Two-hybrid Homo sapiens
155 C6orf222  
Affinity Capture-MS Homo sapiens
156 ZRANB1 54764
Affinity Capture-MS Homo sapiens
157 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
158 ALG13 79868
Affinity Capture-MS Homo sapiens
159 Anapc2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
160 SALL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
162 FASN 2194
Negative Genetic Homo sapiens
163 CDC20 991
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 SIRT6  
Affinity Capture-MS Homo sapiens
165 DAB2 1601
Two-hybrid Homo sapiens
166 NXF1 10482
Affinity Capture-RNA Homo sapiens
167 TRPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 ATP5J 522
Affinity Capture-MS Homo sapiens
170 MKS1 54903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 LINC00839  
Protein-RNA Homo sapiens
172 PRR14L 253143
Affinity Capture-MS Homo sapiens
173 IQGAP3 128239
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 MEN1 4221
Affinity Capture-MS Homo sapiens
175 SKP1 6500
Affinity Capture-MS Homo sapiens
176 PHF8  
Affinity Capture-MS Homo sapiens
177 TROAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 ANAPC1 64682
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 CREBBP  
Affinity Capture-Western Homo sapiens
180 EIF4ENIF1 56478
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 TTK 7272
Affinity Capture-Western Homo sapiens
182 FAM83H 286077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 MAP7D3 79649
Affinity Capture-MS Homo sapiens
184 RAVER1 125950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 MAGIX 79917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 PHLDB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 ANAPC2 29882
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 ESPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 STIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 TRIM37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 NEK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 MED12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 MOV10 4343
Affinity Capture-RNA Homo sapiens
194 PSMA5 5686
Affinity Capture-MS Homo sapiens
195 PXN 5829
Proximity Label-MS Homo sapiens
196 FHOD3  
Affinity Capture-MS Homo sapiens
197 TTC8 123016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 BRD1 23774
Affinity Capture-MS Homo sapiens
199 KRAS 3845
Negative Genetic Homo sapiens
200 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
201 CNOT10 25904
Affinity Capture-MS Homo sapiens
202 ALOX5  
Affinity Capture-MS Homo sapiens
203 ZNF318 24149
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
204 C16orf87 388272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 GTSE1 51512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 NSUN5  
Affinity Capture-MS Homo sapiens
207 EP300 2033
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
208 CDC5L 988
Affinity Capture-MS Homo sapiens
209 Cdc26  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which CDC16 is involved
PathwayEvidenceSource
Aberrant regulation of mitotic cell cycle due to RB1 defects TAS Reactome
Aberrant regulation of mitotic exit in cancer due to RB1 defects TAS Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
Autodegradation of Cdh1 by Cdh1:APC/C TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
CDK-mediated phosphorylation and removal of Cdc6 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase TAS Reactome
Disease TAS Reactome
Diseases of mitotic cell cycle TAS Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Immune System TAS Reactome
Inactivation of APC/C via direct inhibition of the APC/C complex TAS Reactome
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components TAS Reactome
M Phase TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
Phosphorylation of the APC/C TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
RNA Polymerase II Transcription TAS Reactome
S Phase TAS Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Separation of Sister Chromatids TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis of DNA TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome





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