Gene description for CEP131
Gene name centrosomal protein 131kDa
Gene symbol CEP131
Other names/aliases AZ1
AZI1
ZA1
Species Homo sapiens
 Database cross references - CEP131
ExoCarta ExoCarta_22994
Vesiclepedia VP_22994
Entrez Gene 22994
HGNC 29511
MIM 613479
UniProt Q9UPN4  
 CEP131 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for CEP131
Molecular Function
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
    protein-containing complex binding GO:0044877 IDA
Biological Process
    sperm axoneme assembly GO:0007288 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    regulation of centrosome duplication GO:0010824 IBA
    regulation of centrosome duplication GO:0010824 IMP
    intraciliary transport involved in cilium assembly GO:0035735 IMP
    cilium assembly GO:0060271 IBA
    protein localization to centrosome GO:0071539 IMP
    positive regulation of intracellular protein transport GO:0090316 IMP
    manchette assembly GO:1905198 IEA
    non-motile cilium assembly GO:1905515 IEA
    intramanchette transport GO:1990953 IEA
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    manchette GO:0002177 IEA
    nucleoplasm GO:0005654 IDA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 IDA
    centriole GO:0005814 IEA
    cytosol GO:0005829 TAS
    nuclear membrane GO:0031965 IDA
    centriolar satellite GO:0034451 IBA
    centriolar satellite GO:0034451 IDA
    ciliary transition zone GO:0035869 IDA
    ciliary basal body GO:0036064 IDA
    sperm head-tail coupling apparatus GO:0120212 IEA
 Experiment description of studies that identified CEP131 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CEP131
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif19a  
Affinity Capture-MS Mus musculus
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 Edc4  
Affinity Capture-MS Mus musculus
4 MAGEA3  
Affinity Capture-MS Homo sapiens
5 POT1  
Affinity Capture-MS Homo sapiens
6 CENPE 1062
Affinity Capture-MS Homo sapiens
7 CDC14A  
Proximity Label-MS Homo sapiens
8 TPTE2  
Proximity Label-MS Homo sapiens
9 FAM184A 79632
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 HSPA12B 116835
Proximity Label-MS Homo sapiens
11 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MAP4 4134
Affinity Capture-MS Homo sapiens
13 PXN 5829
Proximity Label-MS Homo sapiens
14 DCTN2 10540
Proximity Label-MS Homo sapiens
15 CAMSAP2  
Proximity Label-MS Homo sapiens
16 KIF7 374654
Affinity Capture-MS Homo sapiens
17 ANKRD50 57182
Affinity Capture-MS Homo sapiens
18 APEX1 328
Affinity Capture-RNA Homo sapiens
19 TEX264 51368
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 Sdccag8  
Affinity Capture-MS Mus musculus
21 CDC16 8881
Affinity Capture-MS Homo sapiens
22 PCNT  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
23 MLLT4 4301
Proximity Label-MS Homo sapiens
24 DYRK1A 1859
Affinity Capture-MS Homo sapiens
25 Cep55 74107
Affinity Capture-MS Mus musculus
26 CCDC14  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
27 Cetn2  
Affinity Capture-MS Mus musculus
28 Cep170  
Affinity Capture-MS Mus musculus
29 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CALM3 808
Affinity Capture-MS Homo sapiens
31 Fgfr1op  
Affinity Capture-MS Mus musculus
32 Ankrd26  
Affinity Capture-MS Mus musculus
33 YWHAG 7532
Affinity Capture-MS Homo sapiens
34 Cenpe  
Affinity Capture-MS Mus musculus
35 Mib1  
Affinity Capture-MS Mus musculus
36 EFCAB2  
Affinity Capture-MS Homo sapiens
37 DYNLL1 8655
Affinity Capture-MS Homo sapiens
38 Cbx4  
Affinity Capture-MS Mus musculus
39 DCTN1 1639
Proximity Label-MS Homo sapiens
40 YWHAH 7533
Affinity Capture-MS Homo sapiens
41 POLR2C 5432
Proximity Label-MS Homo sapiens
42 PTPN22  
Proximity Label-MS Homo sapiens
43 Sec24c  
Affinity Capture-MS Mus musculus
44 Cep120  
Affinity Capture-MS Mus musculus
45 Haus4  
Affinity Capture-MS Mus musculus
46 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 LTBR 4055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ANAPC2 29882
Proximity Label-MS Homo sapiens
49 PFN1 5216
Proximity Label-MS Homo sapiens
50 AURKA 6790
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
51 HAUS2  
Affinity Capture-MS Homo sapiens
52 MIB1 57534
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
53 MCC 4163
Affinity Capture-MS Homo sapiens
54 PIBF1  
Affinity Capture-MS Homo sapiens
55 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 Cep104  
Affinity Capture-MS Mus musculus
57 OFD1 8481
Affinity Capture-MS Homo sapiens
58 TSSK1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 YWHAE 7531
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
60 NTRK1 4914
Affinity Capture-MS Homo sapiens
61 PNMA2  
Affinity Capture-MS Homo sapiens
62 PPP2CA 5515
Affinity Capture-MS Homo sapiens
63 PEX14 5195
Proximity Label-MS Homo sapiens
64 Bag2  
Affinity Capture-MS Mus musculus
65 CSNK1E 1454
Affinity Capture-MS Homo sapiens
66 STIL  
Proximity Label-MS Homo sapiens
67 IGFL3  
Affinity Capture-MS Homo sapiens
68 Cdk5rap2  
Affinity Capture-MS Mus musculus
69 LATS2 26524
Proximity Label-MS Homo sapiens
70 FGFR1OP  
Affinity Capture-MS Homo sapiens
71 Cep290  
Affinity Capture-MS Mus musculus
72 Cep131  
Affinity Capture-MS Mus musculus
73 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
74 Ccp110  
Affinity Capture-MS Mus musculus
75 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 WHAMMP3  
Affinity Capture-MS Homo sapiens
77 Cit 12704
Affinity Capture-MS Mus musculus
78 AURKAIP1  
Affinity Capture-Western Homo sapiens
79 KRT18 3875
Proximity Label-MS Homo sapiens
80 PTEN 5728
Affinity Capture-MS Homo sapiens
81 YWHAZ 7534
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
82 Dlg5  
Affinity Capture-MS Mus musculus
83 TUBB4B 10383
Affinity Capture-MS Homo sapiens
84 PTK2 5747
Proximity Label-MS Homo sapiens
85 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 SASS6 163786
Proximity Label-MS Homo sapiens
87 Cep152  
Affinity Capture-MS Mus musculus
88 CCDC85A  
Affinity Capture-MS Homo sapiens
89 NXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CDK5RAP2 55755
Proximity Label-MS Homo sapiens
91 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 Csnk1e  
Affinity Capture-MS Mus musculus
93 RPA3 6119
Proximity Label-MS Homo sapiens
94 Cep72  
Affinity Capture-MS Mus musculus
95 SLAIN2  
Affinity Capture-MS Homo sapiens
96 MYO6 4646
Proximity Label-MS Homo sapiens
97 Uso1 56041
Affinity Capture-MS Mus musculus
98 SAV1  
Proximity Label-MS Homo sapiens
99 GOLGA1  
Proximity Label-MS Homo sapiens
100 Cep78  
Affinity Capture-MS Mus musculus
101 NDC80 10403
Proximity Label-MS Homo sapiens
102 AMOT 154796
Proximity Label-MS Homo sapiens
103 DNAJB13  
Proximity Label-MS Homo sapiens
104 Nedd1  
Affinity Capture-MS Mus musculus
105 PCM1 5108
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
106 CTNNA1 1495
Proximity Label-MS Homo sapiens
107 KRT19 3880
Proximity Label-MS Homo sapiens
108 TMEM59 9528
Affinity Capture-MS Homo sapiens
109 Prkar2a 19087
Affinity Capture-MS Mus musculus
110 KRT2 3849
Affinity Capture-MS Homo sapiens
111 PPP2CB 5516
Affinity Capture-MS Homo sapiens
112 Prkacb 18749
Affinity Capture-MS Mus musculus
113 CCDC8  
Affinity Capture-MS Homo sapiens
114 DNAJC4  
Proximity Label-MS Homo sapiens
115 MAPKAPK2 9261
Biochemical Activity Homo sapiens
116 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
117 SIRT6  
Affinity Capture-MS Homo sapiens
118 SLMAP 7871
Proximity Label-MS Homo sapiens
119 PYCARD 29108
Affinity Capture-MS Homo sapiens
120 TRIM52  
Affinity Capture-MS Homo sapiens
121 LRRCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 CENPJ 55835
Affinity Capture-MS Homo sapiens
123 Ccdc77  
Affinity Capture-MS Mus musculus
124 Cep135  
Affinity Capture-MS Mus musculus
125 AGPS 8540
Proximity Label-MS Homo sapiens
126 SEPT10 151011
Proximity Label-MS Homo sapiens
127 NHLRC2 374354
Affinity Capture-MS Homo sapiens
128 DNAJB5  
Proximity Label-MS Homo sapiens
129 RASSF2 9770
Proximity Label-MS Homo sapiens
130 MAPRE3  
Proximity Label-MS Homo sapiens
131 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
132 LATS1  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
133 Myh10 77579
Affinity Capture-MS Mus musculus
134 Lrrcc1  
Affinity Capture-MS Mus musculus
135 WWP2 11060
Affinity Capture-MS Homo sapiens
136 TRIM37  
Proximity Label-MS Homo sapiens
137 KDM1A 23028
Proximity Label-MS Homo sapiens
138 PPP2R3C  
Affinity Capture-MS Homo sapiens
139 KRT8 3856
Proximity Label-MS Homo sapiens
140 NEDD1 121441
Affinity Capture-MS Homo sapiens
141 CEP135  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
142 DNAJC6  
Proximity Label-MS Homo sapiens
143 DHFRL1  
Proximity Label-MS Homo sapiens
144 AR 367
Affinity Capture-MS Homo sapiens
145 Pcm1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
146 SPZ1  
Proximity Label-MS Homo sapiens
147 RCOR1  
Affinity Capture-MS Homo sapiens
148 C17orf59 54785
Proximity Label-MS Homo sapiens
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