Gene description for NFYA
Gene name nuclear transcription factor Y, alpha
Gene symbol NFYA
Other names/aliases CBF-A
CBF-B
HAP2
NF-YA
Species Homo sapiens
 Database cross references - NFYA
ExoCarta ExoCarta_4800
Vesiclepedia VP_4800
Entrez Gene 4800
HGNC 7804
MIM 189903
UniProt P23511  
 NFYA identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for NFYA
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISS
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    transcription by RNA polymerase II GO:0006366 TAS
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    rhythmic process GO:0048511 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    CCAAT-binding factor complex GO:0016602 IBA
    CCAAT-binding factor complex GO:0016602 IDA
    CCAAT-binding factor complex GO:0016602 IPI
    protein-DNA complex GO:0032993 IDA
    RNA polymerase II transcription regulator complex GO:0090575 IDA
 Experiment description of studies that identified NFYA in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NFYA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2A1 2957
Two-hybrid Homo sapiens
2 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TRIM5 85363
Co-fractionation Homo sapiens
4 CDC25A  
Two-hybrid Homo sapiens
5 TAF6 6878
Reconstituted Complex Homo sapiens
6 MINK1 50488
Affinity Capture-MS Homo sapiens
7 FTO 79068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 POLR2H 5437
Co-fractionation Homo sapiens
9 IPO5 3843
Affinity Capture-MS Homo sapiens
10 ELF1 1997
Reconstituted Complex Homo sapiens
11 UAP1 6675
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 JUP 3728
Co-fractionation Homo sapiens
13 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 CTNNB1 1499
Co-fractionation Homo sapiens
16 ATF6  
Two-hybrid Homo sapiens
17 ZHX1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 APPBP2  
Two-hybrid Homo sapiens
19 Nfyc 18046
Affinity Capture-MS Mus musculus
20 SP1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 ATF2  
Affinity Capture-Western Homo sapiens
22 NFYC 4802
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
23 BRCA1 672
Affinity Capture-Western Homo sapiens
24 ATF6B  
Two-hybrid Homo sapiens
25 BROX 148362
Affinity Capture-MS Homo sapiens
26 SMNDC1  
Co-fractionation Homo sapiens
27 CSNK2A1 1457
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 HMGCS1 3157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 PDXP 57026
Affinity Capture-MS Homo sapiens
31 PHAX  
Affinity Capture-MS Homo sapiens
32 SHMT2 6472
Affinity Capture-RNA Homo sapiens
33 PAPOLG  
Two-hybrid Homo sapiens
34 CREB1  
Affinity Capture-MS Homo sapiens
35 PRKDC 5591
Co-fractionation Homo sapiens
36 APP 351
Reconstituted Complex Homo sapiens
37 ZC3H10  
Two-hybrid Homo sapiens
38 NXF1 10482
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
39 ESR1  
Affinity Capture-MS Homo sapiens
40 TLR9  
Affinity Capture-MS Homo sapiens
41 PWP1 11137
Two-hybrid Homo sapiens
42 JUN 3725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 UBE2D2 7322
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TAF11  
Reconstituted Complex Homo sapiens
45 LUC7L2 51631
Two-hybrid Homo sapiens
46 NFYB  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
47 MOV10 4343
Affinity Capture-RNA Homo sapiens
48 SREBF2 6721
Two-hybrid Homo sapiens
49 POGZ 23126
Two-hybrid Homo sapiens
50 ME1 4199
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ACTN4 81
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 TAF12  
Reconstituted Complex Homo sapiens
53 TCAF1 9747
Two-hybrid Homo sapiens
54 TP63  
Affinity Capture-Western Homo sapiens
55 TOP1 7150
Co-fractionation Homo sapiens
56 TES 26136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 KAT2B  
Affinity Capture-Western Homo sapiens
58 PARP1 142
Co-fractionation Homo sapiens
59 HMGA2 8091
Co-fractionation Homo sapiens
60 SRF  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
61 XRCC6 2547
Co-fractionation Homo sapiens
62 HSPA4L 22824
Co-fractionation Homo sapiens
63 STAT3 6774
Co-fractionation Homo sapiens
64 EIF2S2 8894
Co-fractionation Homo sapiens
65 NPM1 4869
Co-fractionation Homo sapiens
66 TDG 6996
Co-fractionation Homo sapiens
67 SPI1  
Reconstituted Complex Homo sapiens
68 HMGA1 3159
Far Western Homo sapiens
69 EIF4EBP2 1979
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 SERPINB1 1992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 LASP1 3927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 XRCC5 7520
Co-fractionation Homo sapiens
73 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 IRGQ 126298
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 RPS6KA6 27330
Co-fractionation Homo sapiens
76 CHMP4A 29082
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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