Gene description for PIAS1
Gene name	protein inhibitor of activated STAT, 1
Gene symbol	PIAS1
Other names/aliases	DDXBP1 GBP GU/RH-II ZMIZ3
Species	Homo sapiens
Database cross references - PIAS1
ExoCarta	ExoCarta_8554
Vesiclepedia	VP_8554
Entrez Gene	8554
HGNC	2752
MIM	603566
UniProt	O75925
PIAS1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for PIAS1

Molecular Function     transcription cis-regulatory region binding GO:0000976 ISS     transcription coregulator activity GO:0003712 IBA     transcription corepressor activity GO:0003714 TAS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     SUMO transferase activity GO:0019789 EXP     SUMO transferase activity GO:0019789 TAS     enzyme binding GO:0019899 IPI     protein domain specific binding GO:0019904 IEA     ubiquitin protein ligase binding GO:0031625 IEA     SUMO ligase activity GO:0061665 IBA     SUMO ligase activity GO:0061665 IDA     DNA-binding transcription factor binding GO:0140297 IEA Biological Process     G1/S transition of mitotic cell cycle GO:0000082 IEA     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     regulation of transcription by RNA polymerase II GO:0006357 IBA     DNA damage response GO:0006974 IDA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 TAS     spermatogenesis GO:0007283 IEA     visual learning GO:0008542 IEA     protein sumoylation GO:0016925 IBA     protein sumoylation GO:0016925 IDA     protein sumoylation GO:0016925 IEA     protein sumoylation GO:0016925 ISS     protein sumoylation GO:0016925 TAS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS     positive regulation of protein sumoylation GO:0033235 IDA     regulation of cell population proliferation GO:0042127 ISS     negative regulation of apoptotic process GO:0043066 IEA     fat cell differentiation GO:0045444 IEA     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of smooth muscle cell differentiation GO:0051152 IEA     protein-DNA complex assembly GO:0065004 IEA     positive regulation of protein localization to cell periphery GO:1904377 IEA Subcellular Localization     chromatin GO:0000785 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cytoskeleton GO:0005856 IEA     PML body GO:0016605 ISS     nuclear speck GO:0016607 IEA     nuclear periphery GO:0034399 ISS     glutamatergic synapse GO:0098978 IEA     presynaptic cytosol GO:0099523 IEA     postsynaptic cytosol GO:0099524 IEA