Gene description for CSK
Gene name c-src tyrosine kinase
Gene symbol CSK
Other names/aliases -
Species Homo sapiens
 Database cross references - CSK
ExoCarta ExoCarta_1445
Vesiclepedia VP_1445
Entrez Gene 1445
HGNC 2444
MIM 124095
UniProt P41240  
 CSK identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for CSK
Molecular Function
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein phosphatase binding GO:0019903 IEA
    protein kinase A catalytic subunit binding GO:0034236 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
    proline-rich region binding GO:0070064 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
    protein tyrosine kinase binding GO:1990782 IEA
Biological Process
    adaptive immune response GO:0002250 IEA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 TAS
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of low-density lipoprotein particle clearance GO:0010989 IEA
    T cell costimulation GO:0031295 TAS
    negative regulation of interleukin-6 production GO:0032715 IEA
    adherens junction organization GO:0034332 IBA
    negative regulation of Golgi to plasma membrane protein transport GO:0042997 IDA
    negative regulation of bone resorption GO:0045779 IEA
    oligodendrocyte differentiation GO:0048709 IEA
    negative regulation of phagocytosis GO:0050765 IEA
    T cell receptor signaling pathway GO:0050852 TAS
    regulation of Fc receptor mediated stimulatory signaling pathway GO:0060368 IBA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA
    cellular response to peptide hormone stimulus GO:0071375 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IPI
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CSK in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
9
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CSK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATG16L1 55054
Affinity Capture-MS Homo sapiens
2 RASA1 5921
Reconstituted Complex Homo sapiens
3 PDCD6 10016
Co-fractionation Homo sapiens
4 SRCIN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 TNS3 64759
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 FRK 2444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SDC3  
Reconstituted Complex Homo sapiens
10 SERBP1 26135
Affinity Capture-MS Homo sapiens
11 DAB2 1601
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 PIAS3  
Affinity Capture-Western Homo sapiens
13 CD247 919
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 GRB2 2885
Affinity Capture-MS Homo sapiens
15 SHC1 6464
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
16 MATK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PTPN22  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ZNF212  
Two-hybrid Homo sapiens
19 PTEN 5728
Negative Genetic Homo sapiens
20 DAG1 1605
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
21 SRC 6714
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
22 ILKAP 80895
Co-fractionation Homo sapiens
23 TNS1 7145
Affinity Capture-MS Homo sapiens
24 CD3E 916
Reconstituted Complex Homo sapiens
25 RIN3  
Affinity Capture-MS Homo sapiens
26 G3BP1 10146
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
27 INSR 3643
Two-hybrid Homo sapiens
28 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
29 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
30 PARK2  
Affinity Capture-MS Homo sapiens
31 PTK2 5747
Affinity Capture-Western Homo sapiens
32 IGF1R 3480
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
33 ERBB3 2065
Affinity Capture-MS Homo sapiens
34 Csk 12988
Affinity Capture-MS Mus musculus
35 DDX58 23586
Affinity Capture-RNA Homo sapiens
36 TNRC6B  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
37 HNRNPK 3190
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
38 RAD50 10111
Affinity Capture-MS Homo sapiens
39 PSMD14 10213
Affinity Capture-MS Homo sapiens
40 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
41 JUN 3725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
42 RGS16 6004
Biochemical Activity Homo sapiens
43 UBE2I 7329
Biochemical Activity Homo sapiens
44 PAG1 55824
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
45 UBASH3B 84959
Affinity Capture-MS Homo sapiens
46 DNASE1L2  
Affinity Capture-MS Homo sapiens
47 EIF4E 1977
Co-fractionation Homo sapiens
48 CGRRF1  
Affinity Capture-MS Homo sapiens
49 RPA3 6119
Proximity Label-MS Homo sapiens
50 PC 5091
Co-fractionation Homo sapiens
51 VCP 7415
Affinity Capture-MS Homo sapiens
52 ARRB1 408
Affinity Capture-Western Homo sapiens
53 PTPN12 5782
Proximity Label-MS Homo sapiens
54 MCM2 4171
Affinity Capture-MS Homo sapiens
55 PXN 5829
Affinity Capture-Western Homo sapiens
56 C20orf27 54976
Co-fractionation Homo sapiens
57 ZAP70 7535
Reconstituted Complex Homo sapiens
58 TGFB1I1 7041
Reconstituted Complex Homo sapiens
59 PIAS1 8554
Affinity Capture-Western Homo sapiens
60 AKT2 208
Co-fractionation Homo sapiens
61 TNS2 23371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 LDLR 3949
Negative Genetic Homo sapiens
63 PSMD9 5715
Co-fractionation Homo sapiens
64 SNW1 22938
Affinity Capture-MS Homo sapiens
65 DDRGK1 65992
Affinity Capture-MS Homo sapiens
66 NPM1 4869
Proximity Label-MS Homo sapiens
67 FYN 2534
Affinity Capture-Western Homo sapiens
68 FAM188A 80013
Affinity Capture-MS Homo sapiens
69 AKT1 207
Co-fractionation Homo sapiens
70 ID3  
Two-hybrid Homo sapiens
71 CAV1 857
Two-hybrid Homo sapiens
72 FHL2 2274
Two-hybrid Homo sapiens
73 PECAM1 5175
Biochemical Activity Homo sapiens
74 KANK4  
Two-hybrid Homo sapiens
75 PIAS4  
Affinity Capture-Western Homo sapiens
76 PEAK1 79834
Affinity Capture-MS Homo sapiens
77 CLIC4 25932
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which CSK is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Costimulation by the CD28 family TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
FLT3 Signaling TAS Reactome
GAB1 signalosome TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Integrin signaling TAS Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Negative regulation of FLT3 TAS Reactome
Oncogenic MAPK signaling TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
PD-1 signaling TAS Reactome
Phosphorylation of CD3 and TCR zeta chains TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
RAF/MAP kinase cascade TAS Reactome
RHO GTPase cycle TAS Reactome
RHOH GTPase cycle TAS Reactome
Signal Transduction TAS Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
TCR signaling TAS Reactome





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