Gene description for IGF1R
Gene name insulin-like growth factor 1 receptor
Gene symbol IGF1R
Other names/aliases CD221
IGFIR
IGFR
JTK13
Species Homo sapiens
 Database cross references - IGF1R
ExoCarta ExoCarta_3480
Vesiclepedia VP_3480
Entrez Gene 3480
HGNC 5465
MIM 147370
UniProt P08069  
 IGF1R identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Melanoma cells 25950383    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for IGF1R
Molecular Function
    G-protein alpha-subunit binding GO:0001965 IEA
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 TAS
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IBA
    insulin-like growth factor receptor activity GO:0005010 IDA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    insulin receptor binding GO:0005158 IDA
    structural molecule activity GO:0005198 IDA
    protein binding GO:0005515 IPI
    insulin-like growth factor binding GO:0005520 IDA
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    insulin-like growth factor I binding GO:0031994 IDA
    insulin-like growth factor I binding GO:0031994 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    identical protein binding GO:0042802 IPI
    phosphatidylinositol 3-kinase binding GO:0043548 IPI
    insulin binding GO:0043559 IPI
    insulin receptor substrate binding GO:0043560 IBA
    insulin receptor substrate binding GO:0043560 IPI
    protein-containing complex binding GO:0044877 IEA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    protein transporter activity GO:0140318 IMP
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    cardiac atrium development GO:0003230 IEA
    chromatin remodeling GO:0006338 IEA
    immune response GO:0006955 IMP
    signal transduction GO:0007165 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    axonogenesis GO:0007409 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    insulin receptor signaling pathway GO:0008286 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    negative regulation of muscle cell apoptotic process GO:0010656 IEA
    cerebellum development GO:0021549 IEA
    hippocampus development GO:0021766 IEA
    establishment of cell polarity GO:0030010 IEA
    positive regulation of cell migration GO:0030335 IMP
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    positive regulation of cytokinesis GO:0032467 IEA
    response to vitamin E GO:0033197 IEA
    positive regulation of osteoblast proliferation GO:0033690 IEA
    cellular response to zinc ion starvation GO:0034224 IEA
    response to nicotine GO:0035094 IEA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    peptidyl-tyrosine autophosphorylation GO:0038083 IMP
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    negative regulation of apoptotic process GO:0043066 IDA
    positive regulation of protein-containing complex disassembly GO:0043243 ISS
    response to alkaloid GO:0043279 IEA
    negative regulation of MAPK cascade GO:0043409 IDA
    positive regulation of MAPK cascade GO:0043410 IBA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IC
    estrous cycle GO:0044849 IEA
    transcytosis GO:0045056 IMP
    response to ethanol GO:0045471 IEA
    regulation of JNK cascade GO:0046328 IBA
    regulation of JNK cascade GO:0046328 IDA
    protein autophosphorylation GO:0046777 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IBA
    insulin-like growth factor receptor signaling pathway GO:0048009 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 TAS
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    positive regulation of axon regeneration GO:0048680 IEA
    positive regulation of DNA metabolic process GO:0051054 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    cellular response to mechanical stimulus GO:0071260 IEA
    cellular response to glucose stimulus GO:0071333 IBA
    cellular response to estradiol stimulus GO:0071392 IEA
    cellular response to progesterone stimulus GO:0071393 IEA
    cellular response to testosterone stimulus GO:0071394 IEA
    cellular response to dexamethasone stimulus GO:0071549 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    positive regulation of steroid hormone biosynthetic process GO:0090031 IEA
    cellular senescence GO:0090398 IEA
    dendritic spine maintenance GO:0097062 ISS
    amyloid-beta clearance GO:0097242 IMP
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    response to L-glutamate GO:1902065 IEA
    negative regulation of hepatocyte apoptotic process GO:1903944 IEA
    cellular response to aldosterone GO:1904045 IEA
    negative regulation of cholangiocyte apoptotic process GO:1904193 IEA
    cellular response to angiotensin GO:1904385 IEA
    cellular response to amyloid-beta GO:1904646 IGI
    cellular response to insulin-like growth factor stimulus GO:1990314 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    insulin receptor complex GO:0005899 IBA
    caveola GO:0005901 IEA
    membrane GO:0016020 IDA
    T-tubule GO:0030315 IEA
    axon GO:0030424 IBA
    alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 IDA
    neuronal cell body GO:0043025 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    receptor complex GO:0043235 IDA
    protein kinase complex GO:1902911 IDA
 Experiment description of studies that identified IGF1R in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for IGF1R
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-Western Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 CDK3 1018
Affinity Capture-MS Homo sapiens
5 SHC1 6464
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
6 CD48 962
Affinity Capture-MS Homo sapiens
7 CSK 1445
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 LAMP1 3916
Co-localization Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 IGFBP3 3486
Co-purification Homo sapiens
11 YWHAE 7531
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
12 DUSP15  
Two-hybrid Homo sapiens
13 LGALS1 3956
Affinity Capture-MS Homo sapiens
14 SOCS1  
Two-hybrid Homo sapiens
15 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
16 GRB10 2887
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
17 PTPN1 5770
Affinity Capture-Western Homo sapiens
18 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 SLURP1  
Affinity Capture-MS Homo sapiens
20 PRKDC 5591
Negative Genetic Homo sapiens
21 KCNIP3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 HSPA5 3309
Affinity Capture-MS Homo sapiens
23 CELA3A  
Affinity Capture-MS Homo sapiens
24 RUVBL1 8607
Co-fractionation Homo sapiens
25 YWHAZ 7534
Affinity Capture-MS Homo sapiens
26 INSRR 3645
Affinity Capture-MS Homo sapiens
27 PTPN12 5782
Two-hybrid Homo sapiens
28 CARKD 55739
Affinity Capture-MS Homo sapiens
29 DUSP14 11072
Two-hybrid Homo sapiens
30 STAT3 6774
Co-localization Homo sapiens
31 DUSP21  
Two-hybrid Homo sapiens
32 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 C11orf52 91894
Proximity Label-MS Homo sapiens
34 PTPRR  
Two-hybrid Homo sapiens
35 IGF2 3481
Affinity Capture-MS Homo sapiens
36 PPM1A 5494
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
37 SOCS3 9021
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
38 ERBB2 2064
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
39 Insr  
Affinity Capture-MS Mus musculus
40 NEDD4 4734
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 EEF1A1 1915
Affinity Capture-MS Homo sapiens
42 EHD1 10938
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
43 LAMTOR1 55004
Proximity Label-MS Homo sapiens
44 SFTPC  
Affinity Capture-MS Homo sapiens
45 EEA1 8411
Affinity Capture-Western Homo sapiens
46 DUSP18  
Two-hybrid Homo sapiens
47 YWHAB 7529
Reconstituted Complex Homo sapiens
48 CAMP 820
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
49 ATP5A1 498
Affinity Capture-MS Homo sapiens
50 Arrb1  
Affinity Capture-Western Rattus norvegicus
51 CLU 1191
Affinity Capture-MS Homo sapiens
52 HSP90B1 7184
Affinity Capture-MS Homo sapiens
53 GNAI1 2770
Affinity Capture-Western Homo sapiens
54 LYN 4067
Proximity Label-MS Homo sapiens
55 CBL 867
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
56 IDS  
Affinity Capture-MS Homo sapiens
57 SDF2L1 23753
Affinity Capture-MS Homo sapiens
58 FIBIN  
Affinity Capture-MS Homo sapiens
59 NTRK1 4914
Affinity Capture-MS Homo sapiens
60 CRKL 1399
Co-localization Homo sapiens
61 SMAD3 4088
Co-fractionation Homo sapiens
62 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 CHEK1  
Negative Genetic Homo sapiens
64 EEF2 1938
Affinity Capture-MS Homo sapiens
65 YWHAQ 10971
Affinity Capture-MS Homo sapiens
66 DHFRL1  
Affinity Capture-MS Homo sapiens
67 PIK3R1 5295
Co-localization Homo sapiens
68 BRAF  
Affinity Capture-MS Homo sapiens
69 ARHGEF12 23365
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
70 Slc23a3  
Two-hybrid Mus musculus
71 YAP1 10413
Affinity Capture-MS Homo sapiens
72 SLC25A5 292
Affinity Capture-MS Homo sapiens
73 SNAP29 9342
Affinity Capture-Western Homo sapiens
74 LY86  
Affinity Capture-MS Homo sapiens
75 AMY2A 279
Two-hybrid Homo sapiens
76 CAD 790
Affinity Capture-MS Homo sapiens
77 GPIHBP1  
Affinity Capture-MS Homo sapiens
78 FGD5  
Affinity Capture-Western Homo sapiens
79 PTPN11 5781
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
80 DUSP19  
Two-hybrid Homo sapiens
81 SOCS2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
82 ADAMTS4  
Affinity Capture-MS Homo sapiens
83 CANX 821
Affinity Capture-MS Homo sapiens
84 PXN 5829
Affinity Capture-Western Homo sapiens
85 FFAR2  
Two-hybrid Homo sapiens
86 PTPN6 5777
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
87 ILKAP 80895
Two-hybrid Homo sapiens
88 CTNNB1 1499
Affinity Capture-MS Homo sapiens
89 CUL3 8452
Affinity Capture-MS Homo sapiens
90 DUSP26 78986
Two-hybrid Homo sapiens
91 IGF1  
Reconstituted Complex Homo sapiens
92 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 DNAJB9 4189
Affinity Capture-MS Homo sapiens
94 LYZL1  
Affinity Capture-MS Homo sapiens
95 FBXO6 26270
Affinity Capture-MS Homo sapiens
96 PTPN7 5778
Two-hybrid Homo sapiens
97 RPS27 6232
Affinity Capture-MS Homo sapiens
98 PTK2 5747
Affinity Capture-Western Homo sapiens
99 JAK1 3716
Reconstituted Complex Homo sapiens
100 FBXO2 26232
Affinity Capture-MS Homo sapiens
101 FDPS 2224
Co-fractionation Homo sapiens
102 MTOR 2475
Negative Genetic Homo sapiens
103 PSMC5 5705
Affinity Capture-MS Homo sapiens
104 GRB14 2888
Two-hybrid Homo sapiens
105 PPP6C 5537
Affinity Capture-MS Homo sapiens
106 MPZL2 10205
Affinity Capture-Western Homo sapiens
107 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
108 RHOB 388
Proximity Label-MS Homo sapiens
109 CLTC 1213
Co-localization Homo sapiens
110 STYX  
Two-hybrid Homo sapiens
111 RPL11 6135
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
112 CDKN1B 1027
Negative Genetic Homo sapiens
113 DUPD1  
Two-hybrid Homo sapiens
114 MDM2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
115 SLC23A3  
Affinity Capture-Western Homo sapiens
116 RPS16 6217
Affinity Capture-MS Homo sapiens
117 PPM1F 9647
Affinity Capture-Western Homo sapiens
118 LYZL2  
Affinity Capture-MS Homo sapiens
119 RASA1 5921
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
120 ARRB2 409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 PHB2 11331
Affinity Capture-Western Homo sapiens
122 DUSP10 11221
Two-hybrid Homo sapiens
123 JUP 3728
Affinity Capture-MS Homo sapiens
124 TP53 7157
Affinity Capture-Western Homo sapiens
125 SSH1  
Affinity Capture-Western Homo sapiens
126 HSPA8 3312
Affinity Capture-MS Homo sapiens
127 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
128 HDAC6 10013
Negative Genetic Homo sapiens
129 CDC37 11140
Affinity Capture-MS Homo sapiens
130 RPS4X 6191
Affinity Capture-MS Homo sapiens
131 TUBA4A 7277
Affinity Capture-MS Homo sapiens
132 INSR 3643
Affinity Capture-MS Homo sapiens
133 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
134 EIF4A3 9775
Affinity Capture-MS Homo sapiens
135 SLAMF1 6504
Affinity Capture-MS Homo sapiens
136 MAP2K1 5604
Affinity Capture-MS Homo sapiens
137 PCNA 5111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
138 UBB 7314
Affinity Capture-MS Homo sapiens
139 ARRB1 408
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
140 ARPP19 10776
Cross-Linking-MS (XL-MS) Homo sapiens
141 EPHA2 1969
Proximity Label-MS Homo sapiens
142 CST11  
Affinity Capture-MS Homo sapiens
143 KRAS 3845
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
144 UNC5CL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 GNB2L1 10399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
146 VAV3 10451
Affinity Capture-Western Homo sapiens
147 RPS3 6188
Affinity Capture-MS Homo sapiens
148 IRS1 3667
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
149 CAV1 857
Co-localization Homo sapiens
150 CDKN2A 1029
Negative Genetic Homo sapiens
151 PIK3R3 8503
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here