Gene description for IRS1
Gene name	insulin receptor substrate 1
Gene symbol	IRS1
Other names/aliases	HIRS-1
Species	Homo sapiens
Database cross references - IRS1
ExoCarta	ExoCarta_3667
Vesiclepedia	VP_3667
Entrez Gene	3667
HGNC	6125
MIM	147545
UniProt	P35568
IRS1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for IRS1

Molecular Function     phosphotyrosine residue binding GO:0001784 IPI     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISS     protein kinase C binding GO:0005080 ISS     insulin receptor binding GO:0005158 IBA     insulin receptor binding GO:0005158 IPI     insulin-like growth factor receptor binding GO:0005159 IPI     protein binding GO:0005515 IPI     signaling receptor complex adaptor activity GO:0030159 IDA     signaling adaptor activity GO:0035591 IDA     SH2 domain binding GO:0042169 ISS     phosphatidylinositol 3-kinase binding GO:0043548 IBA     phosphatidylinositol 3-kinase binding GO:0043548 IPI     phosphatidylinositol 3-kinase binding GO:0043548 ISS Biological Process     signal transduction GO:0007165 TAS     positive regulation of cell population proliferation GO:0008284 NAS     insulin receptor signaling pathway GO:0008286 IBA     insulin receptor signaling pathway GO:0008286 IDA     insulin receptor signaling pathway GO:0008286 IMP     insulin receptor signaling pathway GO:0008286 IPI     positive regulation of glucose metabolic process GO:0010907 IMP     cytokine-mediated signaling pathway GO:0019221 IGI     positive regulation of fatty acid beta-oxidation GO:0032000 IMP     response to insulin GO:0032868 IDA     cellular response to insulin stimulus GO:0032869 IMP     glucose homeostasis GO:0042593 TAS     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA     positive regulation of glycogen biosynthetic process GO:0045725 IMP     positive regulation of glycogen biosynthetic process GO:0045725 NAS     positive regulation of D-glucose import GO:0046326 IDA     positive regulation of D-glucose import GO:0046326 IMP     negative regulation of insulin receptor signaling pathway GO:0046627 ISS     positive regulation of insulin receptor signaling pathway GO:0046628 IDA     positive regulation of insulin receptor signaling pathway GO:0046628 ISS     negative regulation of insulin secretion GO:0046676 IDA     insulin-like growth factor receptor signaling pathway GO:0048009 IPI     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     cellular response to fatty acid GO:0071398 ISS Subcellular Localization     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 ISS     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     insulin receptor complex GO:0005899 ISS     caveola GO:0005901 IDA     intracellular membrane-bounded organelle GO:0043231 ISS