Gene description for ZDHHC18
Gene name zinc finger, DHHC-type containing 18
Gene symbol ZDHHC18
Other names/aliases DHHC-18
DHHC18
Species Homo sapiens
 Database cross references - ZDHHC18
ExoCarta ExoCarta_84243
Vesiclepedia VP_84243
Entrez Gene 84243
HGNC 20712
UniProt Q9NUE0  
 ZDHHC18 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ZDHHC18
Molecular Function
    palmitoyltransferase activity GO:0016409 IDA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IBA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IDA
Biological Process
    protein targeting to membrane GO:0006612 IBA
    peptidyl-L-cysteine S-palmitoylation GO:0018230 IMP
    protein palmitoylation GO:0018345 IDA
    innate immune response GO:0045087 IEA
    negative regulation of innate immune response GO:0045824 IDA
    negative regulation of cGAS/STING signaling pathway GO:0160049 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified ZDHHC18 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZDHHC18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 SNX1 6642
Affinity Capture-MS Homo sapiens
4 GPM6A 2823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RING1 6015
Affinity Capture-MS Homo sapiens
6 INS 3630
Affinity Capture-MS Homo sapiens
7 VPS26A 9559
Affinity Capture-MS Homo sapiens
8 TMEM63C  
Affinity Capture-MS Homo sapiens
9 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 INSR 3643
Affinity Capture-MS Homo sapiens
11 RPS25 6230
Affinity Capture-MS Homo sapiens
12 RPS11 6205
Affinity Capture-MS Homo sapiens
13 TMEM74  
Affinity Capture-MS Homo sapiens
14 TTYH1  
Affinity Capture-MS Homo sapiens
15 SIN3A  
Affinity Capture-MS Homo sapiens
16 TP53 7157
Affinity Capture-MS Homo sapiens
17 SIDT2 51092
Affinity Capture-MS Homo sapiens
18 AKT1 207
Affinity Capture-MS Homo sapiens
19 NCOA1  
Affinity Capture-MS Homo sapiens
20 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 VPS35 55737
Affinity Capture-MS Homo sapiens
22 IGF1  
Affinity Capture-MS Homo sapiens
23 IL9R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 RNF144A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SLC1A5 6510
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TSPAN15 23555
Affinity Capture-MS Homo sapiens
28 C19orf38  
Affinity Capture-MS Homo sapiens
29 SLC34A2 10568
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 VSTM1  
Affinity Capture-MS Homo sapiens
31 ETF1 2107
Affinity Capture-MS Homo sapiens
32 ZDHHC23  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NCOR2  
Affinity Capture-MS Homo sapiens
35 DDX58 23586
Affinity Capture-RNA Homo sapiens
36 SNX6 58533
Affinity Capture-MS Homo sapiens
37 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PPARA  
Affinity Capture-MS Homo sapiens
39 TMEM169  
Affinity Capture-MS Homo sapiens
40 PIK3CD 5293
Affinity Capture-MS Homo sapiens
41 GOLGA7 51125
Co-purification Homo sapiens
42 KRTCAP3 200634
Affinity Capture-MS Homo sapiens
43 LRRC55  
Affinity Capture-MS Homo sapiens
44 GSPT2 23708
Affinity Capture-MS Homo sapiens
45 LDLR 3949
Positive Genetic Homo sapiens
46 PCDHGC4  
Affinity Capture-MS Homo sapiens
47 CTLA4  
Affinity Capture-MS Homo sapiens
48 GDPD5 81544
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RXRA 6256
Affinity Capture-MS Homo sapiens
51 UPF1 5976
Affinity Capture-MS Homo sapiens
52 MTOR 2475
Affinity Capture-MS Homo sapiens
53 PIK3CA 5290
Affinity Capture-MS Homo sapiens
54 TBL1X 6907
Affinity Capture-MS Homo sapiens
55 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 PCGF1 84759
Affinity Capture-MS Homo sapiens
57 TNFRSF10C  
Affinity Capture-MS Homo sapiens
58 SNX2 6643
Affinity Capture-MS Homo sapiens
59 RNF2  
Affinity Capture-MS Homo sapiens
60 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 UPK1A 11045
Affinity Capture-MS Homo sapiens
63 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 IRS1 3667
Affinity Capture-MS Homo sapiens
65 BMI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
66 C3orf52  
Affinity Capture-MS Homo sapiens
67 ITGA8 8516
Affinity Capture-MS Homo sapiens
68 PCDHAC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZDHHC18 is involved
No pathways found





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