Gene description for TBL1X
Gene name transducin (beta)-like 1X-linked
Gene symbol TBL1X
Other names/aliases EBI
SMAP55
TBL1
Species Homo sapiens
 Database cross references - TBL1X
ExoCarta ExoCarta_6907
Vesiclepedia VP_6907
Entrez Gene 6907
HGNC 11585
MIM 300196
UniProt O60907  
 TBL1X identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TBL1X
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    chromatin binding GO:0003682 IEA
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IDA
    transcription corepressor activity GO:0003714 IGI
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    proteolysis GO:0006508 IMP
    sensory perception of sound GO:0007605 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    response to estrogen GO:0043627 IEA
    fat cell differentiation GO:0045444 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    response to steroid hormone GO:0048545 IEA
    protein stabilization GO:0050821 ISS
    positive regulation of canonical Wnt signaling pathway GO:0090263 IMP
Subcellular Localization
    histone deacetylase complex GO:0000118 IBA
    histone deacetylase complex GO:0000118 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    transcription repressor complex GO:0017053 IDA
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified TBL1X in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TBL1X
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
2 GATA1  
Proximity Label-MS Homo sapiens
3 HIST2H2BE 8349
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
4 CDC34 997
Biochemical Activity Homo sapiens
5 HDAC4  
Affinity Capture-MS Homo sapiens
6 NFIB  
Proximity Label-MS Homo sapiens
7 THRB 7068
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 SP1  
Co-fractionation Homo sapiens
9 GATA2  
Proximity Label-MS Homo sapiens
10 EN1  
Proximity Label-MS Homo sapiens
11 EMD 2010
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 TRIM33 51592
Co-fractionation Homo sapiens
13 SMARCD2 6603
Co-fractionation Homo sapiens
14 SOX10  
Proximity Label-MS Homo sapiens
15 SOX2  
Proximity Label-MS Homo sapiens
16 MYOD1  
Proximity Label-MS Homo sapiens
17 HIST2H2AA3 8337
Reconstituted Complex Homo sapiens
18 IL17F  
Affinity Capture-MS Homo sapiens
19 HDAC3 8841
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 NCOR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 ERF  
Affinity Capture-MS Homo sapiens
22 UBA5 79876
Affinity Capture-MS Homo sapiens
23 HR  
Two-hybrid Homo sapiens
24 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
25 CDK2AP1  
Affinity Capture-MS Homo sapiens
26 KHDRBS1 10657
Two-hybrid Homo sapiens
27 GUSBP5  
Affinity Capture-MS Homo sapiens
28 GCM1  
Proximity Label-MS Homo sapiens
29 TINF2  
Two-hybrid Homo sapiens
30 TEAD1  
Proximity Label-MS Homo sapiens
31 CCL26  
Affinity Capture-MS Homo sapiens
32 LHX4  
Proximity Label-MS Homo sapiens
33 IL17RA 23765
Affinity Capture-MS Homo sapiens
34 TLX3  
Proximity Label-MS Homo sapiens
35 LRRC36  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SMARCB1 6598
Co-fractionation Homo sapiens
37 SOX5 6660
Proximity Label-MS Homo sapiens
38 HIST2H4A 8370
Reconstituted Complex Homo sapiens
39 METTL10  
Affinity Capture-MS Homo sapiens
40 SOX6  
Proximity Label-MS Homo sapiens
41 UBE2E3 10477
Affinity Capture-Western Homo sapiens
42 HIST2H3C 126961
Reconstituted Complex Homo sapiens
43 PRDM1  
Proximity Label-MS Homo sapiens
44 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
45 SOX17  
Proximity Label-MS Homo sapiens
46 RBX1 9978
Affinity Capture-Western Homo sapiens
47 FKBP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CUL4B 8450
Affinity Capture-Western Homo sapiens
49 CTBP1 1487
Affinity Capture-Western Homo sapiens
50 NCOR2  
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
51 SNRNP40 9410
Co-fractionation Homo sapiens
52 TBR1  
Proximity Label-MS Homo sapiens
53 NFIX 4784
Proximity Label-MS Homo sapiens
54 UBE2I 7329
Biochemical Activity Homo sapiens
55 GID8 54994
Co-fractionation Homo sapiens
56 NFIA 4774
Proximity Label-MS Homo sapiens
57 HAO2  
Affinity Capture-MS Homo sapiens
58 FOXK2  
Affinity Capture-MS Homo sapiens
59 TAB2  
Reconstituted Complex Homo sapiens
60 KIF11 3832
Co-fractionation Homo sapiens
61 T  
Proximity Label-MS Homo sapiens
62 HDAC5 10014
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
63 VSX1  
Proximity Label-MS Homo sapiens
64 GPS2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
65 GATA3  
Proximity Label-MS Homo sapiens
66 TLX2  
Proximity Label-MS Homo sapiens
67 PAX6  
Proximity Label-MS Homo sapiens
68 C1orf111  
Affinity Capture-MS Homo sapiens
69 DGKG  
Affinity Capture-MS Homo sapiens
70 XPO1 7514
Affinity Capture-MS Homo sapiens
71 SMARCD1 6602
Co-fractionation Homo sapiens
72 BAG2 9532
Affinity Capture-MS Homo sapiens
73 LY6G5B  
Affinity Capture-MS Homo sapiens
74 PPARG 5468
Proximity Label-MS Homo sapiens
75 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
76 FOXI1  
Proximity Label-MS Homo sapiens
77 MECP2 4204
Reconstituted Complex Homo sapiens
78 FOXL1  
Proximity Label-MS Homo sapiens
79 THRA  
Reconstituted Complex Homo sapiens
80 HNF4A  
Proximity Label-MS Homo sapiens
81 NRD1 4898
Affinity Capture-Western Homo sapiens
82 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
83 TBL1X 6907
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
84 DDB1 1642
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
85 NANOG  
Affinity Capture-MS Homo sapiens
86 FHL2 2274
Affinity Capture-MS Homo sapiens
87 GBAP1  
Affinity Capture-MS Homo sapiens
88 HUWE1 10075
Co-fractionation Homo sapiens
89 UBE2D1 7321
Biochemical Activity Homo sapiens
90 TLX1  
Proximity Label-MS Homo sapiens
91 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
92 SMARCD3  
Co-fractionation Homo sapiens
93 HDGF 3068
Co-fractionation Homo sapiens
94 HORMAD2  
Affinity Capture-MS Homo sapiens
95 SIN3A  
Affinity Capture-Western Homo sapiens
96 KLHDC3  
Affinity Capture-MS Homo sapiens
97 SKP1 6500
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
98 USP44  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
100 TKT 7086
Affinity Capture-MS Homo sapiens
101 ZDHHC23  
Affinity Capture-MS Homo sapiens
102 PAX9  
Proximity Label-MS Homo sapiens
103 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 PPP4R1L  
Affinity Capture-MS Homo sapiens
105 PAX7  
Proximity Label-MS Homo sapiens
106 TERF1 7013
Two-hybrid Homo sapiens
107 HP 3240
Two-hybrid Homo sapiens
108 TBL1Y  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 ARL3 403
Two-hybrid Homo sapiens
110 DNAJB4 11080
Two-hybrid Homo sapiens
111 TSC22D4 81628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 WDR59 79726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 HSD17B7P2  
Affinity Capture-MS Homo sapiens
115 HNF1B  
Proximity Label-MS Homo sapiens
116 NFIC 4782
Proximity Label-MS Homo sapiens
117 AR 367
Proximity Label-MS Homo sapiens
118 MKX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 SSRP1 6749
Affinity Capture-MS Homo sapiens
120 CCT8L2  
Affinity Capture-MS Homo sapiens
121 SP7  
Proximity Label-MS Homo sapiens
122 CACYBP 27101
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
123 RCOR1  
Co-fractionation Homo sapiens
124 DLX3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TBL1X is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) TAS Reactome
Adipogenesis TAS Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression IEA Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress IEA Reactome
Cellular responses to stress TAS Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Circadian Clock IEA Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Cytoprotection by HMOX1 TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Disorders of Developmental Biology IEA Reactome
Disorders of Nervous System Development IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HDACs deacetylate histones TAS Reactome
Heme signaling IEA Reactome
Infectious disease TAS Reactome
Loss of function of MECP2 in Rett syndrome IEA Reactome
Loss of MECP2 binding ability to the NCoR/SMRT complex IEA Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of lipids TAS Reactome
Metabolism of lipids IEA Reactome
Metabolism of steroids TAS Reactome
Mitochondrial biogenesis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Notch-HLH transcription pathway TAS Reactome
NOTCH1 Intracellular Domain Regulates Transcription IEA Reactome
NR1H2 and NR1H3-mediated signaling TAS Reactome
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux TAS Reactome
Organelle biogenesis and maintenance TAS Reactome
Pervasive developmental disorders IEA Reactome
PPARA activates gene expression TAS Reactome
PPARA activates gene expression IEA Reactome
Regulation of cholesterol biosynthesis by SREBP (SREBF) TAS Reactome
Regulation of lipid metabolism by PPARalpha TAS Reactome
Regulation of lipid metabolism by PPARalpha IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RORA activates gene expression IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Transcriptional activation of mitochondrial biogenesis TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transcriptional regulation of white adipocyte differentiation TAS Reactome
Viral Infection Pathways TAS Reactome





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