Gene description for ALK
Gene name	anaplastic lymphoma receptor tyrosine kinase
Gene symbol	ALK
Other names/aliases	CD246 NBLST3
Species	Homo sapiens
Database cross references - ALK
ExoCarta	ExoCarta_238
Vesiclepedia	VP_238
Entrez Gene	238
HGNC	427
MIM	105590
UniProt	Q9UM73
ALK identified in sEVs derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for ALK

Molecular Function     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 TAS     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     transmembrane receptor protein tyrosine kinase activity GO:0004714 TAS     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     heparin binding GO:0008201 IDA     boss receptor activity GO:0008288 IEA     receptor signaling protein tyrosine kinase activator activity GO:0030298 IDA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     identical protein binding GO:0042802 IPI     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     chromatin remodeling GO:0006338 IEA     response to stress GO:0006950 IEA     signal transduction GO:0007165 TAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     phosphorylation GO:0016310 IDA     hippocampus development GO:0021766 IEA     adult behavior GO:0030534 IEA     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     swimming behavior GO:0036269 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     peptidyl-tyrosine autophosphorylation GO:0038083 IDA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     regulation of cell population proliferation GO:0042127 IBA     regulation of apoptotic process GO:0042981 TAS     regulation of neuron differentiation GO:0045664 IBA     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 TAS     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     neuron development GO:0048666 TAS     negative regulation of lipid catabolic process GO:0050995 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     regulation of dopamine receptor signaling pathway GO:0060159 IEA     response to environmental enrichment GO:0090648 IEA     energy homeostasis GO:0097009 ISS     positive regulation of dendrite development GO:1900006 ISS Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     protein-containing complex GO:0032991 IDA     receptor complex GO:0043235 IBA     extracellular exosome GO:0070062 HDA