Gene description for SHC1
Gene name SHC (Src homology 2 domain containing) transforming protein 1
Gene symbol SHC1
Other names/aliases SHC
SHCA
Species Homo sapiens
 Database cross references - SHC1
ExoCarta ExoCarta_6464
Vesiclepedia VP_6464
Entrez Gene 6464
HGNC 10840
MIM 600560
UniProt P29353  
 SHC1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
 Gene ontology annotations for SHC1
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 TAS
    epidermal growth factor receptor binding GO:0005154 ISS
    insulin receptor binding GO:0005158 IPI
    insulin-like growth factor receptor binding GO:0005159 IPI
    neurotrophin TRKA receptor binding GO:0005168 IPI
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 TAS
    receptor tyrosine kinase binding GO:0030971 IBA
    ephrin receptor binding GO:0046875 IPI
    epidermal growth factor binding GO:0048408 IEA
Biological Process
    angiogenesis GO:0001525 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    heart development GO:0007507 IEA
    positive regulation of cell population proliferation GO:0008284 ISS
    insulin receptor signaling pathway GO:0008286 IBA
    insulin receptor signaling pathway GO:0008286 ISS
    negative regulation of angiogenesis GO:0016525 IGI
    actin cytoskeleton organization GO:0030036 IEA
    intracellular signal transduction GO:0035556 IEA
    defense response to bacterium GO:0042742 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of MAPK cascade GO:0043410 IDA
    positive regulation of MAPK cascade GO:0043410 IMP
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of DNA-templated transcription GO:0045893 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    cellular response to growth factor stimulus GO:0071363 IDA
    positive regulation of cell proliferation in bone marrow GO:0071864 IGI
    regulation of superoxide metabolic process GO:0090322 IGI
    cell-cell adhesion GO:0098609 IEA
Subcellular Localization
    mitochondrial matrix GO:0005759 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IEA
    Shc-EGFR complex GO:0070435 ISS
 Experiment description of studies that identified SHC1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
9
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for SHC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
2 TUBB2B 347733
Affinity Capture-MS Homo sapiens
3 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
4 KRT4 3851
Affinity Capture-MS Homo sapiens
5 HDAC4  
Affinity Capture-MS Homo sapiens
6 TUBA8 51807
Affinity Capture-MS Homo sapiens
7 AP2B1 163
Affinity Capture-MS Homo sapiens
8 Grb2  
Affinity Capture-Western Rattus norvegicus
9 KRT1 3848
Affinity Capture-MS Homo sapiens
10 SHC1 6464
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 STAT5B 6777
Affinity Capture-Western Homo sapiens
12 PRKCD 5580
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
13 CSK 1445
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
14 STAT5A 6776
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
15 DAG1 1605
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 KRT6A 3853
Affinity Capture-MS Homo sapiens
17 SQSTM1 8878
Proximity Label-MS Homo sapiens
18 KRT17 3872
Affinity Capture-MS Homo sapiens
19 CDH5  
Affinity Capture-Western Homo sapiens
20 CRK 1398
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 ABL1 25
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
22 GFAP 2670
Affinity Capture-MS Homo sapiens
23 HSPA1L 3305
Affinity Capture-MS Homo sapiens
24 RPS19 6223
Affinity Capture-MS Homo sapiens
25 KIF20A 10112
Affinity Capture-MS Homo sapiens
26 USP9X 8239
Affinity Capture-MS Homo sapiens
27 PRKAA1 5562
Affinity Capture-Western Homo sapiens
28 EPS8 2059
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
29 Socs5  
Affinity Capture-Western Mus musculus
30 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
31 RET 5979
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 HSPA1A 3303
Affinity Capture-MS Homo sapiens
33 PRKDC 5591
Affinity Capture-MS Homo sapiens
34 APP 351
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
35 RFFL 117584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GRB7 2886
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
37 LRP1 4035
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 IL6ST 3572
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
39 RUVBL1 8607
Affinity Capture-MS Homo sapiens
40 PSPH 5723
Co-fractionation Homo sapiens
41 AP1B1 162
Affinity Capture-MS Homo sapiens
42 PLCG2 5336
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 PSTPIP2 9050
Affinity Capture-MS Homo sapiens
44 PTPN12 5782
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 VARS 7407
Affinity Capture-MS Homo sapiens
46 TUBA1C 84790
Affinity Capture-MS Homo sapiens
47 AP2A1 160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ZAP70 7535
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
49 IQGAP1 8826
Affinity Capture-MS Homo sapiens
50 YES1 7525
Affinity Capture-Western Homo sapiens
51 TUBA1B 10376
Affinity Capture-MS Homo sapiens
52 CALD1 800
Affinity Capture-Western Homo sapiens
53 SRC 6714
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 MST1R 4486
Affinity Capture-Western Homo sapiens
55 CALCOCO2  
Two-hybrid Homo sapiens
56 OXT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 KDR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 RASAL2 9462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PLCG1 5335
Affinity Capture-Western Homo sapiens
60 PRKRA 8575
Two-hybrid Homo sapiens
61 ALK 238
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
62 AMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 EPOR  
Affinity Capture-Western Homo sapiens
64 IARS 3376
Affinity Capture-MS Homo sapiens
65 HSPA6 3310
Affinity Capture-MS Homo sapiens
66 TUBA1A 7846
Affinity Capture-MS Homo sapiens
67 SNX27 81609
Affinity Capture-MS Homo sapiens
68 TIMM50 92609
Affinity Capture-MS Homo sapiens
69 CBLB 868
Affinity Capture-Western Homo sapiens
70 RMDN1 51115
Co-fractionation Homo sapiens
71 ERBB2 2064
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
72 FGFR1 2260
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
73 TUBB6 84617
Affinity Capture-MS Homo sapiens
74 CEACAM1 634
Affinity Capture-Western Homo sapiens
75 TRIM15  
PCA Homo sapiens
76 KIF14 9928
Affinity Capture-MS Homo sapiens
77 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 CCT2 10576
Affinity Capture-MS Homo sapiens
79 MAPK1 5594
Affinity Capture-Western Homo sapiens
80 DDR2 4921
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
81 ITGB3 3690
Affinity Capture-Western Homo sapiens
82 KIT 3815
Reconstituted Complex Homo sapiens
83 KRT5 3852
Affinity Capture-MS Homo sapiens
84 SPTA1  
Affinity Capture-MS Homo sapiens
85 RIN3  
Affinity Capture-MS Homo sapiens
86 PLSCR1 5359
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
87 IGF1R 3480
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
88 ERBB3 2065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
89 LYN 4067
Affinity Capture-Western Homo sapiens
90 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
91 TEC 7006
Affinity Capture-MS Homo sapiens
92 CSF2RB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 ACACA 31
Affinity Capture-MS Homo sapiens
94 SH2B2  
Reconstituted Complex Homo sapiens
95 UBASH3B 84959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 NTRK3 4916
Reconstituted Complex Homo sapiens
97 FAM118B  
Two-hybrid Homo sapiens
98 FLT1 2321
Two-hybrid Homo sapiens
99 MAT1A 4143
Co-fractionation Homo sapiens
100 MYH9 4627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PPP1R8 5511
Co-fractionation Homo sapiens
102 ACTN4 81
Affinity Capture-MS Homo sapiens
103 NTRK1 4914
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
104 CRKL 1399
Affinity Capture-Western Homo sapiens
105 KRT9 3857
Affinity Capture-MS Homo sapiens
106 S100A8 6279
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 DNAJA1 3301
Affinity Capture-MS Homo sapiens
108 TBRG4 9238
Proximity Label-MS Homo sapiens
109 PEAK1 79834
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ACTB 60
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 CHMP4B 128866
Affinity Capture-MS Homo sapiens
112 MYH10 4628
Affinity Capture-MS Homo sapiens
113 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
114 MYH11 4629
Affinity Capture-MS Homo sapiens
115 PRSS3 5646
Affinity Capture-MS Homo sapiens
116 GEMIN7  
Two-hybrid Homo sapiens
117 SHCBP1 79801
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
118 DNM2 1785
Affinity Capture-MS Homo sapiens
119 C19orf35  
Affinity Capture-Western Homo sapiens
120 Cd3e  
Reconstituted Complex Mus musculus
121 CLIC4 25932
Co-fractionation Homo sapiens
122 DUSP23 54935
Two-hybrid Homo sapiens
123 ACTG1 71
Affinity Capture-MS Homo sapiens
124 HIF1A 3091
Affinity Capture-Western Homo sapiens
125 ACTA1 58
Affinity Capture-MS Homo sapiens
126 NGFR 4804
Affinity Capture-Western Homo sapiens
127 EGF 1950
Affinity Capture-Western Homo sapiens
128 Gab2  
Affinity Capture-Western Mus musculus
129 DDX5 1655
Affinity Capture-MS Homo sapiens
130 DOK2 9046
Affinity Capture-Western Homo sapiens
131 MRPL44  
Two-hybrid Homo sapiens
132 HSPA5 3309
Affinity Capture-MS Homo sapiens
133 TUBB 203068
Affinity Capture-MS Homo sapiens
134 Hgf  
Affinity Capture-Western Rattus norvegicus
135 ACLY 47
Affinity Capture-MS Homo sapiens
136 AIFM1 9131
Affinity Capture-MS Homo sapiens
137 CD22 933
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
138 XPO1 7514
Affinity Capture-MS Homo sapiens
139 USP15 9958
Affinity Capture-MS Homo sapiens
140 CCT6A 908
Affinity Capture-MS Homo sapiens
141 STXBP1 6812
Co-fractionation Homo sapiens
142 HMOX2 3163
Two-hybrid Homo sapiens
143 MYH14 79784
Affinity Capture-MS Homo sapiens
144 TUBB4B 10383
Affinity Capture-MS Homo sapiens
145 TUBAL3 79861
Affinity Capture-MS Homo sapiens
146 NUDT21 11051
Two-hybrid Homo sapiens
147 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
148 MYO1C 4641
Affinity Capture-MS Homo sapiens
149 S100A7 6278
Affinity Capture-MS Homo sapiens
150 ERBB4 2066
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
151 CTTN 2017
Affinity Capture-MS Homo sapiens
152 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Negative Genetic Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
153 OSGEP 55644
Two-hybrid Homo sapiens
154 PTK2 5747
Affinity Capture-Western Homo sapiens
155 PDGFRB 5159
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
156 CUL9  
Affinity Capture-MS Homo sapiens
157 PIK3C2B 5287
Reconstituted Complex Homo sapiens
158 CORO1C 23603
Affinity Capture-MS Homo sapiens
159 SPTBN1 6711
Affinity Capture-MS Homo sapiens
160 GAB1  
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
161 NXF1 10482
Affinity Capture-RNA Homo sapiens
162 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 KRT14 3861
Affinity Capture-MS Homo sapiens
164 CDC25C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 MAPK6  
Two-hybrid Homo sapiens
166 LRRK1 79705
Affinity Capture-MS Homo sapiens
167 MYO1D 4642
Affinity Capture-MS Homo sapiens
168 CSF3R  
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
169 ARHGEF5  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
170 TUBA4B 80086
Affinity Capture-MS Homo sapiens
171 SEC16A 9919
Affinity Capture-MS Homo sapiens
172 SUV39H2 79723
Two-hybrid Homo sapiens
173 AP2A2 161
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 ITGB4 3691
Co-fractionation Homo sapiens
Far Western Homo sapiens
175 KRT13 3860
Affinity Capture-MS Homo sapiens
176 MET 4233
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
177 IGHG1 3500
Affinity Capture-MS Homo sapiens
178 FCGR2B  
Affinity Capture-Western Homo sapiens
179 DDB1 1642
Affinity Capture-MS Homo sapiens
180 IL2RB  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
181 PLS3 5358
Co-fractionation Homo sapiens
182 ILK 3611
Two-hybrid Homo sapiens
183 CLTC 1213
Affinity Capture-MS Homo sapiens
184 HAX1  
Affinity Capture-MS Homo sapiens
185 INPP5D 3635
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 HSPA9 3313
Affinity Capture-MS Homo sapiens
187 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
188 CSF1R  
Affinity Capture-Western Homo sapiens
189 KRT2 3849
Affinity Capture-MS Homo sapiens
190 KRT16 3868
Affinity Capture-MS Homo sapiens
191 GH1  
Biochemical Activity Homo sapiens
192 KRT77 374454
Affinity Capture-MS Homo sapiens
193 ARAP1 116985
Affinity Capture-MS Homo sapiens
194 CBLC  
Two-hybrid Homo sapiens
195 KRT3 3850
Affinity Capture-MS Homo sapiens
196 Ptpn12 19248
Two-hybrid Mus musculus
197 CLPP 8192
Proximity Label-MS Homo sapiens
198 IKBKAP 8518
Affinity Capture-MS Homo sapiens
199 MAPKAPK2 9261
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
200 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
201 FASN 2194
Affinity Capture-MS Homo sapiens
202 SPTAN1 6709
Affinity Capture-MS Homo sapiens
203 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
204 RAB3GAP2 25782
Affinity Capture-MS Homo sapiens
205 C11orf58  
Two-hybrid Homo sapiens
206 MTPN 136319
Affinity Capture-MS Homo sapiens
207 PDCD2L 84306
Affinity Capture-MS Homo sapiens
208 INPPL1 3636
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
209 ATAD3B 83858
Affinity Capture-MS Homo sapiens
210 RAPGEF1 2889
Affinity Capture-Western Homo sapiens
211 FLT4  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
212 PAG1 55824
Reconstituted Complex Homo sapiens
213 KRT10 3858
Affinity Capture-MS Homo sapiens
214 IL2RG  
Affinity Capture-Western Homo sapiens
215 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
216 GAREM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
217 TUBB3 10381
Affinity Capture-MS Homo sapiens
218 Grap2 17444
Reconstituted Complex Mus musculus
Co-purification Mus musculus
219 SOS1 6654
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
220 INSR 3643
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
221 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
222 RUVBL2 10856
Affinity Capture-MS Homo sapiens
223 PRMT5 10419
Affinity Capture-MS Homo sapiens
224 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
225 DDX19B 11269
Affinity Capture-MS Homo sapiens
226 S100A9 6280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
227 GAB2 9846
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
228 SSBP1 6742
Proximity Label-MS Homo sapiens
229 FGFR2 2263
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
230 ESR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
231 LTK 4058
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
232 IL4R  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
233 DNAJA2 10294
Affinity Capture-MS Homo sapiens
234 ITGAV 3685
Affinity Capture-Western Homo sapiens
235 CORO2B 10391
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
236 DOK1 1796
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
237 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
238 EEF1A1P5 158078
Affinity Capture-MS Homo sapiens
239 MOV10 4343
Affinity Capture-RNA Homo sapiens
240 ERRFI1 54206
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 CAD 790
Affinity Capture-MS Homo sapiens
242 DDR1 780
Reconstituted Complex Homo sapiens
243 PXN 5829
Proximity Label-MS Homo sapiens
244 LCP2 3937
Affinity Capture-Western Homo sapiens
245 PRDX1 5052
Affinity Capture-MS Homo sapiens
246 EPHA2 1969
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
247 SOS2 6655
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
248 PIK3R2 5296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
249 GHR  
Reconstituted Complex Homo sapiens
250 KRAS 3845
Synthetic Lethality Homo sapiens
251 HNRNPU 3192
Affinity Capture-MS Homo sapiens
252 AR 367
Reconstituted Complex Homo sapiens
253 ANXA2 302
Affinity Capture-MS Homo sapiens
254 NTRK2 4915
Reconstituted Complex Homo sapiens
255 VAV3 10451
Affinity Capture-Western Homo sapiens
256 JAK2 3717
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
257 USP9Y 8287
Affinity Capture-MS Homo sapiens
258 HSPA1B 3304
Affinity Capture-MS Homo sapiens
259 CDC5L 988
Affinity Capture-MS Homo sapiens
260 BCR 613
Affinity Capture-MS Homo sapiens
261 SHC2 25759
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SHC1 is involved
PathwayEvidenceSource
Activated NTRK2 signals through RAS IEA Reactome
Activated NTRK3 signals through RAS IEA Reactome
Axon guidance TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Constitutive Signaling by Overexpressed ERBB2 TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signaling of activated FGFR1 TAS Reactome
Downstream signaling of activated FGFR2 TAS Reactome
Downstream signaling of activated FGFR3 TAS Reactome
Downstream signaling of activated FGFR4 TAS Reactome
Erythropoietin activates RAS IEA Reactome
Erythropoietin activates RAS TAS Reactome
ESR-mediated signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
G alpha (s) signalling events TAS Reactome
GPCR downstream signalling TAS Reactome
GPER1 signaling TAS Reactome
Hemostasis TAS Reactome
IGF1R signaling cascade TAS Reactome
IGF1R signaling cascade IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Insulin receptor signalling cascade TAS Reactome
Insulin receptor signalling cascade IEA Reactome
Integrin signaling TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-15 signaling TAS Reactome
Interleukin-15 signaling IEA Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-2 family signaling IEA Reactome
Interleukin-2 signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
IRE1alpha activates chaperones TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MET activates RAS signaling TAS Reactome
Nervous system development TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
RAF/MAP kinase cascade TAS Reactome
RET signaling TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization IEA Reactome
SHC-mediated cascade:FGFR1 TAS Reactome
SHC-mediated cascade:FGFR2 TAS Reactome
SHC-mediated cascade:FGFR3 TAS Reactome
SHC-mediated cascade:FGFR4 TAS Reactome
SHC-related events triggered by IGF1R TAS Reactome
SHC-related events triggered by IGF1R IEA Reactome
SHC1 events in EGFR signaling TAS Reactome
SHC1 events in ERBB2 signaling TAS Reactome
SHC1 events in ERBB2 signaling IEA Reactome
SHC1 events in ERBB4 signaling TAS Reactome
Signal attenuation TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by EGFRvIII in Cancer TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Insulin receptor IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by LTK TAS Reactome
Signaling by MET TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK3 (TRKC) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IEA Reactome
Signalling to ERKs IEA Reactome
Signalling to ERKs TAS Reactome
Signalling to RAS IEA Reactome
Signalling to RAS TAS Reactome
Tie2 Signaling TAS Reactome
Unfolded Protein Response (UPR) TAS Reactome
XBP1(S) activates chaperone genes TAS Reactome





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