Gene description for NTRK3
Gene name neurotrophic tyrosine kinase, receptor, type 3
Gene symbol NTRK3
Other names/aliases GP145-TrkC
TRKC
gp145(trkC)
Species Homo sapiens
 Database cross references - NTRK3
ExoCarta ExoCarta_4916
Vesiclepedia VP_4916
Entrez Gene 4916
HGNC 8033
MIM 191316
UniProt Q16288  
 NTRK3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NTRK3
Molecular Function
    p53 binding GO:0002039 IPI
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    neurotrophin receptor activity GO:0005030 IBA
    neurotrophin receptor activity GO:0005030 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    neurotrophin binding GO:0043121 IBA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    negative regulation of protein phosphorylation GO:0001933 IDA
    positive regulation of protein phosphorylation GO:0001934 TAS
    chromatin remodeling GO:0006338 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    nervous system development GO:0007399 IEA
    heart development GO:0007507 IMP
    positive regulation of cell population proliferation GO:0008284 IDA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of neuron projection development GO:0010976 IBA
    cell differentiation GO:0030154 IEA
    positive regulation of cell migration GO:0030335 IDA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    activation of protein kinase B activity GO:0032148 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    neurotrophin signaling pathway GO:0038179 IEA
    positive regulation of MAP kinase activity GO:0043406 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    positive regulation of positive chemotaxis GO:0050927 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA
    activation of GTPase activity GO:0090630 IDA
    cellular response to nerve growth factor stimulus GO:1990090 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IBA
    receptor complex GO:0043235 IBA
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified NTRK3 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NTRK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NTF3  
Reconstituted Complex Homo sapiens
2 C1GALT1 56913
Affinity Capture-MS Homo sapiens
3 NEU3  
Affinity Capture-MS Homo sapiens
4 TNK2 10188
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 MYADM 91663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ERBB2 2064
PCA Homo sapiens
7 CXCR4 7852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SHC1 6464
Reconstituted Complex Homo sapiens
9 GNB4 59345
Affinity Capture-MS Homo sapiens
10 EHD4 30844
Affinity Capture-MS Homo sapiens
11 FAM171A2 284069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ACAD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SH3BP4 23677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 EFR3A 23167
Affinity Capture-MS Homo sapiens
15 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
16 RPTOR 57521
Affinity Capture-MS Homo sapiens
17 HRAS 3265
Affinity Capture-MS Homo sapiens
18 LGALS1 3956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SQSTM1 8878
Affinity Capture-Western Homo sapiens
20 PTPN1 5770
Protein-peptide Homo sapiens
21 TMEM11 8834
Affinity Capture-MS Homo sapiens
22 LINGO1 84894
Affinity Capture-MS Homo sapiens
23 DDX58 23586
Affinity Capture-RNA Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 ATP7B 540
Affinity Capture-MS Homo sapiens
26 UBE3C 9690
Affinity Capture-MS Homo sapiens
27 PAG1 55824
Affinity Capture-MS Homo sapiens
28 EPHA2 1969
Affinity Capture-MS Homo sapiens
29 PLXNA4 91584
Affinity Capture-Western Homo sapiens
30 HEATR6  
Affinity Capture-MS Homo sapiens
31 PTPRS 5802
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GNB2 2783
Affinity Capture-MS Homo sapiens
33 NTRK1 4914
Affinity Capture-MS Homo sapiens
34 FRS2 10818
Reconstituted Complex Homo sapiens
35 PTCD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MTOR 2475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 INTS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TBC1D24 57465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 C6orf120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ACAD9 28976
Affinity Capture-MS Homo sapiens
41 KIAA0391  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SLC39A11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PLCG1 5335
Reconstituted Complex Homo sapiens
44 IRAK3 11213
Two-hybrid Homo sapiens
45 TMEM192 201931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DENND4A 10260
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here