Gene description for LINGO1
Gene name leucine rich repeat and Ig domain containing 1
Gene symbol LINGO1
Other names/aliases LERN1
LRRN6A
UNQ201
Species Homo sapiens
 Database cross references - LINGO1
ExoCarta ExoCarta_84894
Vesiclepedia VP_84894
Entrez Gene 84894
HGNC 21205
MIM 609791
UniProt Q96FE5  
 LINGO1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for LINGO1
Molecular Function
    epidermal growth factor receptor binding GO:0005154 IBA
    protein binding GO:0005515 IPI
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 TAS
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified LINGO1 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for LINGO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 SGCB 6443
Affinity Capture-MS Homo sapiens
3 NGLY1 55768
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CCL3  
Affinity Capture-MS Homo sapiens
5 DNAJC25-GNG10  
Affinity Capture-MS Homo sapiens
6 GJD3  
Proximity Label-MS Homo sapiens
7 NRROS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 C4orf32  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LINGO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CCDC185  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TMEM57  
Two-hybrid Homo sapiens
12 LCN6  
Affinity Capture-MS Homo sapiens
13 FRS3 10817
Two-hybrid Homo sapiens
14 KRTAP5-6  
Two-hybrid Homo sapiens
15 GOLGA2 2801
Two-hybrid Homo sapiens
16 SPAG5 10615
Two-hybrid Homo sapiens
17 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 POMP  
Affinity Capture-MS Homo sapiens
19 LMAN2L 81562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CLEC4A  
Affinity Capture-MS Homo sapiens
21 CNPY3 10695
Affinity Capture-MS Homo sapiens
22 KRTAP5-9  
Two-hybrid Homo sapiens
23 SLC27A6  
Affinity Capture-MS Homo sapiens
24 SLC5A11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KRTAP10-1  
Two-hybrid Homo sapiens
26 INS 3630
Affinity Capture-MS Homo sapiens
27 PCDHB11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PSMG2 56984
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CLEC12B  
Affinity Capture-MS Homo sapiens
30 KRTAP4-12  
Two-hybrid Homo sapiens
31 MSMB  
Affinity Capture-MS Homo sapiens
32 FBXW7  
Two-hybrid Homo sapiens
33 NTRK3 4916
Affinity Capture-MS Homo sapiens
34 FBXO2 26232
Affinity Capture-MS Homo sapiens
35 LGALS8 3964
Affinity Capture-MS Homo sapiens
36 TRIM27  
Two-hybrid Homo sapiens
37 ACAD9 28976
Affinity Capture-MS Homo sapiens
38 NTM 50863
Two-hybrid Homo sapiens
39 KRTAP9-2  
Two-hybrid Homo sapiens
40 ST14 6768
Affinity Capture-MS Homo sapiens
41 C1QTNF7  
Affinity Capture-MS Homo sapiens
42 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 EFEMP2 30008
Two-hybrid Homo sapiens
44 LRFN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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