Gene description for SGCB
Gene name sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Gene symbol SGCB
Other names/aliases A3b
LGMD2E
SGC
Species Homo sapiens
 Database cross references - SGCB
ExoCarta ExoCarta_6443
Vesiclepedia VP_6443
Entrez Gene 6443
HGNC 10806
MIM 600900
UniProt Q16585  
 SGCB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SGCB
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    muscle organ development GO:0007517 IEA
    response to glucose GO:0009749 IEA
    gene expression GO:0010467 IEA
    glucose homeostasis GO:0042593 IEA
    glucose import in response to insulin stimulus GO:0044381 IEA
    cardiac muscle cell development GO:0055013 IEA
    vascular associated smooth muscle cell development GO:0097084 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 TAS
    dystrophin-associated glycoprotein complex GO:0016010 IDA
    sarcoglycan complex GO:0016012 IBA
    sarcolemma GO:0042383 IBA
 Experiment description of studies that identified SGCB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SGCB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNJ10  
Affinity Capture-MS Homo sapiens
2 ADAM30 11085
Affinity Capture-MS Homo sapiens
3 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CD1A 909
Affinity Capture-MS Homo sapiens
5 PSMB10 5699
Affinity Capture-MS Homo sapiens
6 KLRC3  
Affinity Capture-MS Homo sapiens
7 BTNL2  
Affinity Capture-MS Homo sapiens
8 TMEM106A  
Affinity Capture-MS Homo sapiens
9 GLRA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CHRNA4  
Affinity Capture-MS Homo sapiens
11 SMIM3  
Two-hybrid Homo sapiens
12 TSPAN17 26262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CANX 821
Affinity Capture-MS Homo sapiens
14 ADRA1A  
Two-hybrid Homo sapiens
15 HLA-G 3135
Affinity Capture-MS Homo sapiens
16 PCDHA8  
Affinity Capture-MS Homo sapiens
17 TNF  
Two-hybrid Homo sapiens
18 B4GAT1 11041
Affinity Capture-MS Homo sapiens
19 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
20 CLEC2B  
Affinity Capture-MS Homo sapiens
21 SMIM5  
Affinity Capture-MS Homo sapiens
22 CDH5  
Affinity Capture-MS Homo sapiens
23 ADAM33 80332
Two-hybrid Homo sapiens
24 TNFSF11  
Affinity Capture-MS Homo sapiens
25 EHHADH 1962
Two-hybrid Homo sapiens
26 TNFSF14  
Affinity Capture-MS Homo sapiens
27 HTR3C  
Affinity Capture-MS Homo sapiens
28 CD1B 910
Affinity Capture-MS Homo sapiens
29 ECEL1  
Affinity Capture-MS Homo sapiens
30 NINJ1 4814
Two-hybrid Homo sapiens
31 TMED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TMEM11 8834
Two-hybrid Homo sapiens
33 OR1D4  
Affinity Capture-MS Homo sapiens
34 CLEC7A  
Two-hybrid Homo sapiens
35 TSPAN18 90139
Affinity Capture-MS Homo sapiens
36 HTR2C  
Two-hybrid Homo sapiens
37 ATP1B3 483
Affinity Capture-MS Homo sapiens
38 FRMD5 84978
Affinity Capture-MS Homo sapiens
39 ITGAD  
Affinity Capture-MS Homo sapiens
40 LINGO1 84894
Affinity Capture-MS Homo sapiens
41 IL5RA  
Affinity Capture-MS Homo sapiens
42 LTB4R2  
Two-hybrid Homo sapiens
43 MAL  
Two-hybrid Homo sapiens
44 IL9R  
Affinity Capture-MS Homo sapiens
45 PLTP 5360
Affinity Capture-MS Homo sapiens
46 GAA 2548
Affinity Capture-MS Homo sapiens
47 PILRB 29990
Affinity Capture-MS Homo sapiens
48 APOL3  
Two-hybrid Homo sapiens
49 CHRNB4  
Affinity Capture-MS Homo sapiens
50 CNTNAP3  
Affinity Capture-MS Homo sapiens
51 HLA-DPA1  
Affinity Capture-MS Homo sapiens
52 PCDHB3  
Affinity Capture-MS Homo sapiens
53 CD1E  
Affinity Capture-MS Homo sapiens
54 CMTM5  
Two-hybrid Homo sapiens
55 DCT 1638
Affinity Capture-MS Homo sapiens
56 PSCA 8000
Affinity Capture-MS Homo sapiens
57 NCEH1 57552
Affinity Capture-MS Homo sapiens
58 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ATP1B1 481
Affinity Capture-MS Homo sapiens
60 PCDHA12  
Affinity Capture-MS Homo sapiens
61 CD160  
Affinity Capture-MS Homo sapiens
62 CLEC2D  
Affinity Capture-MS Homo sapiens
63 SGCZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
64 P2RX2  
Affinity Capture-MS Homo sapiens
65 PTTG1IP 754
Two-hybrid Homo sapiens
66 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
67 CHRNE  
Affinity Capture-MS Homo sapiens
68 ST8SIA5  
Affinity Capture-MS Homo sapiens
69 CHRND  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ENTPD2 954
Affinity Capture-MS Homo sapiens
71 SLC52A1  
Two-hybrid Homo sapiens
72 NRROS  
Affinity Capture-MS Homo sapiens
73 BRICD5  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
74 SLC22A9  
Affinity Capture-MS Homo sapiens
75 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SGCD 6444
Affinity Capture-MS Homo sapiens
77 CLRN2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SGCB is involved
No pathways found





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