Gene description for TSPAN18
Gene name tetraspanin 18
Gene symbol TSPAN18
Other names/aliases TSPAN
Species Homo sapiens
 Database cross references - TSPAN18
ExoCarta ExoCarta_90139
Vesiclepedia VP_90139
Entrez Gene 90139
HGNC 20660
UniProt Q96SJ8  
 TSPAN18 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSPAN18
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    inflammatory response GO:0006954 IEA
    hemostasis GO:0007599 IEA
    calcium-ion regulated exocytosis GO:0017156 IEA
    establishment of localization in cell GO:0051649 IEA
    regulation of sprouting angiogenesis GO:1903670 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified TSPAN18 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSPAN18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SGCB 6443
Affinity Capture-MS Homo sapiens
2 GPX8 493869
Affinity Capture-MS Homo sapiens
3 TMEM218  
Two-hybrid Homo sapiens
4 SCNN1A  
Affinity Capture-MS Homo sapiens
5 C3orf58 205428
Affinity Capture-MS Homo sapiens
6 TMEM120A 83862
Two-hybrid Homo sapiens
7 RNF130  
Affinity Capture-MS Homo sapiens
8 TMCO5A  
Two-hybrid Homo sapiens
9 FITM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CHST14 113189
Affinity Capture-MS Homo sapiens
11 ITGA6 3655
Affinity Capture-MS Homo sapiens
12 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
13 OLFM4 10562
Two-hybrid Homo sapiens
14 POMGNT2  
Affinity Capture-MS Homo sapiens
15 CNNM3 26505
Affinity Capture-MS Homo sapiens
16 TMEM181 57583
Affinity Capture-MS Homo sapiens
17 IL1RL1 9173
Two-hybrid Homo sapiens
18 CD151 977
Two-hybrid Homo sapiens
19 ADAM9 8754
Affinity Capture-MS Homo sapiens
20 GRM2 2912
Two-hybrid Homo sapiens
21 HYAL2 8692
Affinity Capture-MS Homo sapiens
22 CXCL9  
Two-hybrid Homo sapiens
23 ANKRD46 157567
Affinity Capture-MS Homo sapiens
24 HS6ST2 90161
Affinity Capture-MS Homo sapiens
25 GIMAP5  
Two-hybrid Homo sapiens
26 SCARB1 949
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSPAN18 is involved
No pathways found





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