Gene description for HS6ST2
Gene name heparan sulfate 6-O-sulfotransferase 2
Gene symbol HS6ST2
Other names/aliases -
Species Homo sapiens
 Database cross references - HS6ST2
ExoCarta ExoCarta_90161
Vesiclepedia VP_90161
Entrez Gene 90161
HGNC 19133
MIM 300545
UniProt Q96MM7  
 HS6ST2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HS6ST2
Molecular Function
    heparan sulfate 6-O-sulfotransferase activity GO:0017095 IBA
    heparan sulfate 6-O-sulfotransferase activity GO:0017095 TAS
Biological Process
    heparan sulfate proteoglycan biosynthetic process, enzymatic modification GO:0015015 IBA
    heparan sulfate proteoglycan biosynthetic process, enzymatic modification GO:0015015 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
 Experiment description of studies that identified HS6ST2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HS6ST2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 LYZL2  
Affinity Capture-MS Homo sapiens
3 PRG2  
Affinity Capture-MS Homo sapiens
4 HLA-G 3135
Affinity Capture-MS Homo sapiens
5 BTNL2  
Affinity Capture-MS Homo sapiens
6 TMEM106A  
Affinity Capture-MS Homo sapiens
7 KLK15  
Affinity Capture-MS Homo sapiens
8 LCN6  
Affinity Capture-MS Homo sapiens
9 TMEM59 9528
Affinity Capture-MS Homo sapiens
10 CANX 821
Affinity Capture-MS Homo sapiens
11 LDLRAD1  
Affinity Capture-MS Homo sapiens
12 FAM3A 60343
Affinity Capture-MS Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 TNF  
Affinity Capture-MS Homo sapiens
15 NRSN1  
Affinity Capture-MS Homo sapiens
16 GGH 8836
Affinity Capture-MS Homo sapiens
17 PON2 5445
Affinity Capture-MS Homo sapiens
18 CST8  
Affinity Capture-MS Homo sapiens
19 PDGFRA 5156
Affinity Capture-MS Homo sapiens
20 VAMP4 8674
Affinity Capture-MS Homo sapiens
21 MFAP4 4239
Affinity Capture-MS Homo sapiens
22 YWHAZ 7534
Affinity Capture-MS Homo sapiens
23 TSPAN18 90139
Affinity Capture-MS Homo sapiens
24 LYZL1  
Affinity Capture-MS Homo sapiens
25 SLURP1  
Affinity Capture-MS Homo sapiens
26 NCR3  
Affinity Capture-MS Homo sapiens
27 CLEC10A  
Affinity Capture-MS Homo sapiens
28 SFTPC  
Affinity Capture-MS Homo sapiens
29 CHST10  
Affinity Capture-MS Homo sapiens
30 CLEC12B  
Affinity Capture-MS Homo sapiens
31 OGFOD3 79701
Affinity Capture-MS Homo sapiens
32 CHRNB2  
Affinity Capture-MS Homo sapiens
33 TM2D3  
Affinity Capture-MS Homo sapiens
34 CHRNB4  
Affinity Capture-MS Homo sapiens
35 BRICD5  
Affinity Capture-MS Homo sapiens
36 SDF2L1 23753
Affinity Capture-MS Homo sapiens
37 FBXO2 26232
Affinity Capture-MS Homo sapiens
38 Pafah1b1 18472
Affinity Capture-MS Mus musculus
39 SCGB2A2  
Affinity Capture-MS Homo sapiens
40 C1orf54  
Affinity Capture-MS Homo sapiens
41 DNAJB9 4189
Affinity Capture-MS Homo sapiens
42 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 NETO2  
Affinity Capture-MS Homo sapiens
44 LGALS1 3956
Affinity Capture-MS Homo sapiens
45 ST14 6768
Affinity Capture-MS Homo sapiens
46 PTCH1  
Affinity Capture-MS Homo sapiens
47 CD1B 910
Affinity Capture-MS Homo sapiens
48 C1QTNF7  
Affinity Capture-MS Homo sapiens
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