Gene description for LTK
Gene name	leukocyte receptor tyrosine kinase
Gene symbol	LTK
Other names/aliases	TYK1
Species	Homo sapiens
Database cross references - LTK
ExoCarta	ExoCarta_4058
Vesiclepedia	VP_4058
Entrez Gene	4058
HGNC	6721
MIM	151520
UniProt	P29376
LTK identified in sEVs derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for LTK

Molecular Function     protein kinase activity GO:0004672 IDA     protein tyrosine kinase activity GO:0004713 EXP     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     receptor signaling protein tyrosine kinase activator activity GO:0030298 IDA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 TAS     signal transduction GO:0007165 TAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IMP     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     cell population proliferation GO:0008283 IDA     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     positive regulation of cardiac muscle cell apoptotic process GO:0010666 IDA     positive regulation of neuron projection development GO:0010976 IMP     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     peptidyl-tyrosine autophosphorylation GO:0038083 IDA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     regulation of cell population proliferation GO:0042127 IBA     negative regulation of apoptotic process GO:0043066 IMP     regulation of neuron differentiation GO:0045664 IBA     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     cellular response to retinoic acid GO:0071300 IMP Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     membrane GO:0016020 IDA     receptor complex GO:0043235 IBA