Gene description for PIK3R1
Gene name phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene symbol PIK3R1
Other names/aliases AGM7
GRB1
IMD36
p85
p85-ALPHA
Species Homo sapiens
 Database cross references - PIK3R1
ExoCarta ExoCarta_5295
Vesiclepedia VP_5295
Entrez Gene 5295
HGNC 8979
MIM 171833
UniProt P27986  
 PIK3R1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for PIK3R1
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISS
    insulin receptor binding GO:0005158 IPI
    insulin-like growth factor receptor binding GO:0005159 IPI
    neurotrophin TRKA receptor binding GO:0005168 IPI
    protein binding GO:0005515 IPI
    kinase activator activity GO:0019209 IEA
    protein phosphatase binding GO:0019903 IPI
    phosphatidylinositol 3-kinase regulator activity GO:0035014 IDA
    phosphatidylinositol 3-kinase regulator activity GO:0035014 ISS
    phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IEA
    ErbB-3 class receptor binding GO:0043125 IDA
    phosphatidylinositol 3-kinase binding GO:0043548 ISS
    insulin binding GO:0043559 IDA
    insulin receptor substrate binding GO:0043560 IEA
    1-phosphatidylinositol-3-kinase regulator activity GO:0046935 IBA
    protein heterodimerization activity GO:0046982 IEA
    phosphatidylinositol kinase activity GO:0052742 ISS
    enzyme-substrate adaptor activity GO:0140767 ISS
    phosphatidylinositol 3-kinase activator activity GO:0141038 ISS
Biological Process
    intracellular glucose homeostasis GO:0001678 ISS
    negative regulation of cell-matrix adhesion GO:0001953 IEA
    positive regulation of leukocyte migration GO:0002687 IEA
    transcription by RNA polymerase II GO:0006366 IEA
    protein import into nucleus GO:0006606 IEA
    immune response GO:0006955 NAS
    insulin receptor signaling pathway GO:0008286 IBA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    positive regulation of lamellipodium assembly GO:0010592 ISS
    cytokine-mediated signaling pathway GO:0019221 IGI
    B cell differentiation GO:0030183 NAS
    T cell differentiation GO:0030217 NAS
    osteoclast differentiation GO:0030316 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    cellular response to insulin stimulus GO:0032869 IDA
    cellular response to insulin stimulus GO:0032869 ISS
    positive regulation of RNA splicing GO:0033120 IMP
    regulation of toll-like receptor 4 signaling pathway GO:0034143 IDA
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    cellular response to UV GO:0034644 IEA
    response to endoplasmic reticulum stress GO:0034976 IDA
    response to endoplasmic reticulum stress GO:0034976 ISS
    interleukin-18-mediated signaling pathway GO:0035655 IMP
    natural killer cell mediated cytotoxicity GO:0042267 IDA
    positive regulation of protein import into nucleus GO:0042307 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISS
    negative regulation of osteoclast differentiation GO:0045671 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    positive regulation of D-glucose import GO:0046326 ISS
    phosphatidylinositol phosphate biosynthetic process GO:0046854 ISS
    insulin-like growth factor receptor signaling pathway GO:0048009 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IPI
    positive regulation of smooth muscle cell proliferation GO:0048661 IMP
    protein stabilization GO:0050821 IDA
    positive regulation of filopodium assembly GO:0051491 ISS
    negative regulation of stress fiber assembly GO:0051497 ISS
    growth hormone receptor signaling pathway GO:0060396 IDA
    T follicular helper cell differentiation GO:0061470 IDA
    myeloid leukocyte migration GO:0097529 IEA
    positive regulation of focal adhesion disassembly GO:0120183 ISS
    positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 IMP
    positive regulation of protein localization to plasma membrane GO:1903078 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IDA
    cis-Golgi network GO:0005801 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    phosphatidylinositol 3-kinase complex GO:0005942 ISS
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IBA
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IPI
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 ISS
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 NAS
    membrane GO:0016020 HDA
    perinuclear region of cytoplasm GO:0048471 ISS
    perinuclear endoplasmic reticulum membrane GO:1990578 IEA
 Experiment description of studies that identified PIK3R1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
13
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PIK3R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
2 SNX32  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NYAP1  
Reconstituted Complex Homo sapiens
4 AXL 558
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
5 Pik3r2  
Affinity Capture-MS Mus musculus
6 TNIP1 10318
Affinity Capture-Western Homo sapiens
7 RNASEH2B  
Co-fractionation Homo sapiens
8 OCLN 100506658
Proximity Label-MS Homo sapiens
9 SHC1 6464
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
10 EBAG9 9166
Proximity Label-MS Homo sapiens
11 FGD2 221472
Affinity Capture-MS Homo sapiens
12 GJA1 2697
Proximity Label-MS Homo sapiens
13 PIK3CD 5293
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
14 CRK 1398
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
15 TTR 7276
Two-hybrid Homo sapiens
16 TRIM66  
Affinity Capture-MS Homo sapiens
17 SOS1 6654
Co-localization Homo sapiens
Co-fractionation Homo sapiens
18 GNAQ 2776
Affinity Capture-Western Homo sapiens
19 BRCA1 672
Reconstituted Complex Homo sapiens
20 HRAS 3265
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
21 FLT3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 SHB 6461
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 VHL  
Negative Genetic Homo sapiens
24 ADAMTS2 9509
Two-hybrid Homo sapiens
25 FES 2242
Affinity Capture-Western Homo sapiens
26 RRAS2 22800
Affinity Capture-Western Homo sapiens
27 ARHGAP1 392
Reconstituted Complex Homo sapiens
28 CD247 919
Affinity Capture-Western Homo sapiens
29 IL21R  
Positive Genetic Homo sapiens
30 TGFBR1 7046
Affinity Capture-Western Homo sapiens
31 TYRO3 7301
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
32 CYP4A11  
Two-hybrid Homo sapiens
33 IL6ST 3572
Affinity Capture-Western Homo sapiens
34 SELPLG 6404
Affinity Capture-Western Homo sapiens
35 HDAC3 8841
Affinity Capture-Western Homo sapiens
36 PLCG2 5336
Co-localization Homo sapiens
37 CHAF1A  
Affinity Capture-MS Homo sapiens
38 IGF1R 3480
Co-localization Homo sapiens
39 MOB2 81532
Affinity Capture-MS Homo sapiens
40 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ZAP70 7535
Affinity Capture-Western Homo sapiens
42 CXADR 1525
Proximity Label-MS Homo sapiens
43 DLX2  
Two-hybrid Homo sapiens
44 YES1 7525
Affinity Capture-Western Homo sapiens
45 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
46 FGFR4 2264
Negative Genetic Homo sapiens
47 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
48 SYK 6850
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
49 YWHAG 7532
Affinity Capture-MS Homo sapiens
50 ABI1 10006
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
51 CD3E 916
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 GAB2 9846
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
53 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
54 PLCG1 5335
Co-fractionation Homo sapiens
55 GSPT1 2935
Two-hybrid Homo sapiens
56 CSF2RA  
Affinity Capture-Western Homo sapiens
57 KBTBD2 25948
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
58 ALK 238
Reconstituted Complex Homo sapiens
59 NPM1 4869
Affinity Capture-MS Homo sapiens
60 EPOR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
61 CD28  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
62 RAB35 11021
Proximity Label-MS Homo sapiens
63 CBLB 868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 FTSJ1 24140
Affinity Capture-MS Homo sapiens
65 SLC31A1 1317
Affinity Capture-MS Homo sapiens
66 ERBB2 2064
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
67 SYNM 23336
Affinity Capture-Western Homo sapiens
68 ACADM 34
Co-fractionation Homo sapiens
69 LAMP1 3916
Proximity Label-MS Homo sapiens
70 Ctnnb1 12387
Affinity Capture-Western Mus musculus
71 SIRT1  
Affinity Capture-Western Homo sapiens
72 FAS 355
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 NYAP2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
74 ADAM12 8038
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
75 RAB5A 5868
Affinity Capture-Western Homo sapiens
76 ZDHHC17 23390
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
77 PTEN 5728
FRET Homo sapiens
78 Arhgap28  
Affinity Capture-MS Mus musculus
79 BCAR1 9564
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
80 KIT 3815
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
81 FASLG 356
Co-localization Homo sapiens
82 VAV1 7409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
83 PPP5C 5536
Affinity Capture-MS Homo sapiens
84 RAB2A 5862
Proximity Label-MS Homo sapiens
85 HCST  
Protein-peptide Homo sapiens
86 CD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
87 PDGFRB 5159
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
88 ERBB3 2065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
89 WDR6 11180
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 LYN 4067
Proximity Label-MS Homo sapiens
91 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
92 VSIG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 HTT 3064
Two-hybrid Homo sapiens
94 SOCS6  
Affinity Capture-MS Homo sapiens
95 MAPT  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
96 FLT1 2321
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
97 FYN 2534
Reconstituted Complex Homo sapiens
98 PIK3CB 5291
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
99 NTRK1 4914
Affinity Capture-MS Homo sapiens
100 CRKL 1399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
101 PTK2B 2185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
102 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 PRMT2  
Affinity Capture-MS Homo sapiens
105 TUBA1B 10376
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
106 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
107 DNM2 1785
Affinity Capture-Western Homo sapiens
108 DNAJB5  
Proximity Label-MS Homo sapiens
109 AGAP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
110 PECAM1 5175
Affinity Capture-Western Homo sapiens
111 MET 4233
Reconstituted Complex Homo sapiens
112 CMIP 80790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
113 Gab2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
114 ARHGAP17 55114
Reconstituted Complex Homo sapiens
115 TPX2  
Affinity Capture-MS Homo sapiens
116 CD40 958
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 LAT 27040
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
118 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
119 ARHGAP32  
Affinity Capture-Western Homo sapiens
120 RAB7A 7879
Proximity Label-MS Homo sapiens
121 C11orf52 91894
Proximity Label-MS Homo sapiens
122 PTPN6 5777
Two-hybrid Homo sapiens
123 CBX3 11335
Affinity Capture-MS Homo sapiens
124 CLTA 1211
Affinity Capture-MS Homo sapiens
125 GP1BA 2811
Reconstituted Complex Homo sapiens
126 CTNNB1 1499
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
127 NFKBIA  
Reconstituted Complex Homo sapiens
128 PDGFRA 5156
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
129 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
130 YWHAZ 7534
Affinity Capture-MS Homo sapiens
131 ERBB4 2066
Reconstituted Complex Homo sapiens
132 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
133 ARF6 382
Proximity Label-MS Homo sapiens
134 PTK2 5747
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
135 KIAA1524 57650
Two-hybrid Homo sapiens
136 HOXA1 3198
Two-hybrid Homo sapiens
137 RIPK4  
Affinity Capture-MS Homo sapiens
138 WEE1 7465
Negative Genetic Homo sapiens
139 GAB1  
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
140 BLK 640
Two-hybrid Homo sapiens
141 NLGN3  
Affinity Capture-MS Homo sapiens
142 LZTS2 84445
Affinity Capture-Western Homo sapiens
143 KCNE3  
Affinity Capture-MS Homo sapiens
144 FGFR2 2263
Affinity Capture-Western Homo sapiens
145 PCBP1 5093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 RASD2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
147 IFNAR1  
Affinity Capture-Western Homo sapiens
148 EPN1 29924
Affinity Capture-Western Homo sapiens
149 PIK3CA 5290
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
150 CD244 51744
Affinity Capture-MS Homo sapiens
151 NCK1 4690
Affinity Capture-Western Homo sapiens
152 DPP7 29952
Co-fractionation Homo sapiens
153 WAS 7454
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
154 IL2RB  
Affinity Capture-Western Homo sapiens
155 FGFR1 2260
Co-localization Homo sapiens
Two-hybrid Homo sapiens
156 RHOB 388
Proximity Label-MS Homo sapiens
157 SHC3  
Affinity Capture-Western Homo sapiens
158 HAX1  
Proximity Label-MS Homo sapiens
159 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
160 EFNB2 1948
Affinity Capture-MS Homo sapiens
161 ARAF 369
Reconstituted Complex Homo sapiens
162 CSF1R  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
163 PXK 54899
Affinity Capture-Western Homo sapiens
164 ITK 3702
Affinity Capture-Western Homo sapiens
165 TGFBR2 7048
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 AR 367
Reconstituted Complex Homo sapiens
167 CXCL2 2920
Two-hybrid Homo sapiens
168 MYO16 23026
Reconstituted Complex Homo sapiens
169 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
170 PROM1 8842
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
171 LAMTOR1 55004
Proximity Label-MS Homo sapiens
172 ITSN1 6453
Two-hybrid Homo sapiens
173 CCL14  
Two-hybrid Homo sapiens
174 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
175 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 INPPL1 3636
Affinity Capture-MS Homo sapiens
177 IL1R1 3554
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 EZR 7430
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
179 Erbb3  
Affinity Capture-Western Rattus norvegicus
180 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 IRS2 8660
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
182 GRB10 2887
Affinity Capture-Western Homo sapiens
183 LCK 3932
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
184 JAK2 3717
Negative Genetic Homo sapiens
Reconstituted Complex Homo sapiens
185 SQSTM1 8878
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 ABL1 25
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
187 INSR 3643
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
188 FCGR2A 2212
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
189 NISCH 11188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 PLEKHG4B 153478
Affinity Capture-MS Homo sapiens
191 GNB1 2782
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
192 Thra  
Affinity Capture-Western Rattus norvegicus
193 PTGER3  
Affinity Capture-MS Homo sapiens
194 Plekhg2  
Affinity Capture-MS Mus musculus
195 ESR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
196 LTK 4058
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
197 DOK1 1796
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
198 ACTA1 58
Affinity Capture-Western Homo sapiens
199 NCL 4691
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
200 RXRA 6256
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
201 PXN 5829
Co-localization Homo sapiens
Co-localization Homo sapiens
202 LCP2 3937
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
203 FLOT1 10211
Proximity Label-MS Homo sapiens
204 EPHA2 1969
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
205 PTPRK 5796
Proximity Label-MS Homo sapiens
206 PIK3R2 5296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 KRAS 3845
Proximity Label-MS Homo sapiens
208 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
209 SYN1  
Affinity Capture-Western Homo sapiens
210 INPP5D 3635
Affinity Capture-Western Homo sapiens
211 NTRK2 4915
Two-hybrid Homo sapiens
212 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
213 ALOX5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
214 IRS1 3667
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
215 CAV1 857
Proximity Label-MS Homo sapiens
216 PIK3R3 8503
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
217 EP300 2033
Affinity Capture-Western Homo sapiens
218 BCR 613
Far Western Homo sapiens
219 MED28  
Affinity Capture-Western Homo sapiens
220 ICOS  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PIK3R1 is involved
PathwayEvidenceSource
Activated NTRK2 signals through PI3K IEA Reactome
Activated NTRK3 signals through PI3K IEA Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Axon guidance TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
CDC42 GTPase cycle TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Cell-Cell communication IEA Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Costimulation by the CD28 family TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers IEA Reactome
Downstream signal transduction TAS Reactome
Downstream signaling of activated FGFR1 TAS Reactome
Downstream signaling of activated FGFR2 TAS Reactome
Downstream signaling of activated FGFR3 TAS Reactome
Downstream signaling of activated FGFR4 TAS Reactome
Downstream TCR signaling TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IEA Reactome
ESR-mediated signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FGFR1 mutant receptor activation TAS Reactome
FLT3 Signaling TAS Reactome
FLT3 Signaling IEA Reactome
FLT3 signaling in disease IEA Reactome
FLT3 signaling in disease TAS Reactome
G alpha (q) signalling events TAS Reactome
GAB1 signalosome TAS Reactome
GP1b-IX-V activation signalling TAS Reactome
GPCR downstream signalling TAS Reactome
GPVI-mediated activation cascade TAS Reactome
Hemostasis TAS Reactome
IGF1R signaling cascade TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Innate Immune System TAS Reactome
Insulin receptor signalling cascade TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Interleukin-7 signaling IEA Reactome
Interleukin-7 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
IRS-mediated signalling TAS Reactome
IRS-related events triggered by IGF1R TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MET activates PI3K/AKT signaling TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nephrin family interactions IEA Reactome
Nervous system development TAS Reactome
Phospholipid metabolism TAS Reactome
PI Metabolism TAS Reactome
PI-3K cascade:FGFR1 TAS Reactome
PI-3K cascade:FGFR2 TAS Reactome
PI-3K cascade:FGFR3 TAS Reactome
PI-3K cascade:FGFR4 TAS Reactome
PI3K Cascade TAS Reactome
PI3K events in ERBB2 signaling TAS Reactome
PI3K events in ERBB4 signaling TAS Reactome
PI3K/AKT activation TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAC3 GTPase cycle TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
RET signaling TAS Reactome
RHO GTPase cycle TAS Reactome
RHOA GTPase cycle TAS Reactome
RHOB GTPase cycle TAS Reactome
RHOC GTPase cycle TAS Reactome
RHOD GTPase cycle TAS Reactome
RHOF GTPase cycle TAS Reactome
RHOG GTPase cycle TAS Reactome
RHOJ GTPase cycle TAS Reactome
RHOU GTPase cycle TAS Reactome
RHOV GTPase cycle TAS Reactome
RND1 GTPase cycle TAS Reactome
RND2 GTPase cycle TAS Reactome
RND3 GTPase cycle TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of phospholipids in phagocytosis TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by cytosolic FGFR1 fusion mutants TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by EGFRvIII in Cancer TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR1 in disease TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 in disease TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR3 in disease TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by FGFR4 in disease TAS Reactome
Signaling by FLT3 fusion proteins IEA Reactome
Signaling by FLT3 fusion proteins TAS Reactome
Signaling by FLT3 ITD and TKD mutants IEA Reactome
Signaling by FLT3 ITD and TKD mutants TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by LTK TAS Reactome
Signaling by LTK in cancer TAS Reactome
Signaling by MET TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK3 (TRKC) IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by PDGF TAS Reactome
Signaling by PDGFR in disease TAS Reactome
Signaling by PDGFRA extracellular domain mutants TAS Reactome
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome
Signaling by VEGF IEA Reactome
Signaling by VEGF TAS Reactome
Synthesis of PIPs at the plasma membrane TAS Reactome
TCR signaling TAS Reactome
Tie2 Signaling TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here