Gene description for IL1R1
Gene name interleukin 1 receptor, type I
Gene symbol IL1R1
Other names/aliases CD121A
D2S1473
IL-1R-alpha
IL1R
IL1RA
P80
Species Homo sapiens
 Database cross references - IL1R1
ExoCarta ExoCarta_3554
Vesiclepedia VP_3554
Entrez Gene 3554
HGNC 5993
MIM 147810
UniProt P14778  
 IL1R1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IL1R1
Molecular Function
    protease binding GO:0002020 IEA
    NAD+ nucleosidase activity GO:0003953 IEA
    transmembrane signaling receptor activity GO:0004888 TAS
    interleukin-1 receptor activity GO:0004908 IBA
    interleukin-1 receptor activity GO:0004908 IDA
    interleukin-1, type I, activating receptor activity GO:0004909 IEA
    platelet-derived growth factor receptor binding GO:0005161 IPI
    protein binding GO:0005515 IPI
    interleukin-1 binding GO:0019966 IEA
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    immune response GO:0006955 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    positive regulation of type II interferon production GO:0032729 IDA
    regulation of inflammatory response GO:0050727 IBA
    interleukin-1-mediated signaling pathway GO:0070498 IBA
    interleukin-1-mediated signaling pathway GO:0070498 IDA
    response to interleukin-1 GO:0070555 IDA
    positive regulation of neutrophil extravasation GO:2000391 IEA
    positive regulation of T-helper 1 cell cytokine production GO:2000556 IDA
    positive regulation of interleukin-1-mediated signaling pathway GO:2000661 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IEA
    cell surface GO:0009986 IBA
    membrane GO:0016020 IDA
 Experiment description of studies that identified IL1R1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IL1R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TICAM2  
Affinity Capture-Western Homo sapiens
2 IRAK2  
Affinity Capture-Western Homo sapiens
3 ICK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MFAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 IL1RN 3557
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
6 TOLLIP 54472
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 MARCH8  
Affinity Capture-Western Homo sapiens
8 IRAK4 51135
Affinity Capture-Western Homo sapiens
9 IL1B  
Reconstituted Complex Homo sapiens
10 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 IRAK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 BMPR1A 657
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 IL1RAP 3556
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 LYN 4067
Affinity Capture-Western Homo sapiens
16 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PELI1 57162
Affinity Capture-Western Homo sapiens
18 MYD88 4615
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 SIGIRR 59307
Affinity Capture-Western Homo sapiens
20 YES1 7525
Affinity Capture-Western Homo sapiens
21 E2F1 1869
Negative Genetic Homo sapiens
22 SRC 6714
Affinity Capture-Western Homo sapiens
23 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 VPS39 23339
Affinity Capture-MS Homo sapiens
25 TOM1 10043
Affinity Capture-Western Homo sapiens
26 ATP2A3 489
Affinity Capture-MS Homo sapiens
27 CSF2RA  
Affinity Capture-Western Homo sapiens
28 SCCPDH 51097
Cross-Linking-MS (XL-MS) Homo sapiens
29 HERPUD1  
Affinity Capture-Western Homo sapiens
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