Gene description for IL1RN
Gene name interleukin 1 receptor antagonist
Gene symbol IL1RN
Other names/aliases DIRA
ICIL-1RA
IL-1RN
IL-1ra
IL-1ra3
IL1F3
IL1RA
IRAP
MVCD4
Species Homo sapiens
 Database cross references - IL1RN
ExoCarta ExoCarta_3557
Vesiclepedia VP_3557
Entrez Gene 3557
HGNC 6000
MIM 147679
UniProt P18510  
 IL1RN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for IL1RN
Molecular Function
    cytokine activity GO:0005125 IEA
    interleukin-1 receptor binding GO:0005149 IDA
    interleukin-1, type I receptor binding GO:0005150 IPI
    interleukin-1, type II receptor binding GO:0005151 IPI
    interleukin-1 receptor antagonist activity GO:0005152 IBA
    interleukin-1 receptor antagonist activity GO:0005152 IDA
    interleukin-1 receptor antagonist activity GO:0005152 TAS
    protein binding GO:0005515 IPI
    interleukin-1 type I receptor antagonist activity GO:0045352 IDA
    interleukin-1 type II receptor antagonist activity GO:0045353 IDA
Biological Process
    negative regulation of cytokine-mediated signaling pathway GO:0001960 IEA
    lipid metabolic process GO:0006629 IEA
    acute-phase response GO:0006953 IDA
    inflammatory response GO:0006954 IBA
    immune response GO:0006955 IBA
    immune response GO:0006955 NAS
    signal transduction GO:0007165 IEA
    insulin secretion GO:0030073 IEA
    negative regulation of heterotypic cell-cell adhesion GO:0034115 IDA
    response to glucocorticoid GO:0051384 IDA
    negative regulation of interleukin-1-mediated signaling pathway GO:2000660 IBA
    negative regulation of interleukin-1-mediated signaling pathway GO:2000660 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    nucleoplasm GO:0005654 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified IL1RN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for IL1RN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RELA 5970
Affinity Capture-MS Homo sapiens
2 GPIHBP1  
Affinity Capture-MS Homo sapiens
3 IL1R2  
Affinity Capture-Western Homo sapiens
4 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
5 C18orf21  
Affinity Capture-MS Homo sapiens
6 POT1  
Two-hybrid Homo sapiens
7 AGPAT1 10554
Affinity Capture-MS Homo sapiens
8 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 IL1R1 3554
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
10 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
12 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 C1orf35  
Affinity Capture-MS Homo sapiens
14 SSBP2  
Affinity Capture-MS Homo sapiens
15 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
16 TERF2IP 54386
Two-hybrid Homo sapiens
17 PTDSS1 9791
Affinity Capture-MS Homo sapiens
18 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SOX2  
Affinity Capture-MS Homo sapiens
20 FNDC5  
Affinity Capture-MS Homo sapiens
21 KLHL11  
Affinity Capture-MS Homo sapiens
22 RNF115  
Affinity Capture-MS Homo sapiens
23 SRRT 51593
Affinity Capture-MS Homo sapiens
24 MBNL1 4154
Affinity Capture-MS Homo sapiens
25 BTBD1  
Affinity Capture-MS Homo sapiens
26 SARAF  
Affinity Capture-MS Homo sapiens
27 PIGT 51604
Affinity Capture-MS Homo sapiens
28 PINK1  
Affinity Capture-MS Homo sapiens
29 GOT1 2805
Affinity Capture-MS Homo sapiens
30 RFK 55312
Affinity Capture-MS Homo sapiens
31 STK11 6794
Affinity Capture-MS Homo sapiens
32 SSUH2  
Affinity Capture-MS Homo sapiens
33 OR2A4 79541
Affinity Capture-MS Homo sapiens
34 FAM213A 84293
Affinity Capture-MS Homo sapiens
35 CCR1  
Affinity Capture-MS Homo sapiens
36 STX17 55014
Affinity Capture-MS Homo sapiens
37 RIPPLY3  
Affinity Capture-MS Homo sapiens
38 SEC22C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PHF11 51131
Affinity Capture-MS Homo sapiens
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