Gene description for PLEKHG4B
Gene name pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
Gene symbol PLEKHG4B
Other names/aliases -
Species Homo sapiens
 Database cross references - PLEKHG4B
ExoCarta ExoCarta_153478
Vesiclepedia VP_153478
Entrez Gene 153478
HGNC 29399
UniProt Q96PX9  
 PLEKHG4B identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PLEKHG4B
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
Biological Process
    axon guidance GO:0007411 IBA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    cell-cell adhesion GO:0098609 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    cell-cell junction GO:0005911 IDA
    basal plasma membrane GO:0009925 IDA
    extrinsic component of membrane GO:0019898 IBA
 Experiment description of studies that identified PLEKHG4B in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLEKHG4B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAT2A 4144
Affinity Capture-MS Homo sapiens
2 MRPS7 51081
Affinity Capture-MS Homo sapiens
3 SURF6  
Affinity Capture-MS Homo sapiens
4 GINS2  
Affinity Capture-MS Homo sapiens
5 ATPIF1 93974
Affinity Capture-MS Homo sapiens
6 SNRPE 6635
Affinity Capture-MS Homo sapiens
7 DSG1 1828
Affinity Capture-MS Homo sapiens
8 SRRM1 10250
Affinity Capture-MS Homo sapiens
9 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DYRK1B  
Affinity Capture-MS Homo sapiens
11 ZYX 7791
Affinity Capture-MS Homo sapiens
12 CAMSAP3  
Affinity Capture-MS Homo sapiens
13 CUL3 8452
Affinity Capture-MS Homo sapiens
14 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
15 CSTA 1475
Affinity Capture-MS Homo sapiens
16 S100A9 6280
Affinity Capture-MS Homo sapiens
17 MAP3K7  
Affinity Capture-MS Homo sapiens
18 CDC42 998
FRET Homo sapiens
19 DUS3L 56931
Affinity Capture-MS Homo sapiens
20 LYAR 55646
Affinity Capture-MS Homo sapiens
21 PIK3R1 5295
Affinity Capture-MS Homo sapiens
22 ARHGEF12 23365
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ARHGEF40 55701
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHG4B is involved
No pathways found





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