Gene description for CXCL2
Gene name chemokine (C-X-C motif) ligand 2
Gene symbol CXCL2
Other names/aliases CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
Species Homo sapiens
 Database cross references - CXCL2
ExoCarta ExoCarta_2920
Vesiclepedia VP_2920
Entrez Gene 2920
HGNC 4603
MIM 139110
UniProt P19875  
 CXCL2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CXCL2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    response to molecule of bacterial origin GO:0002237 IDA
    chemotaxis GO:0006935 TAS
    killing of cells of another organism GO:0031640 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified CXCL2 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CXCL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CXCL5  
Reconstituted Complex Homo sapiens
2 CCL8  
Reconstituted Complex Homo sapiens
3 CXCL1 2919
Affinity Capture-MS Homo sapiens
4 CXCL6  
Reconstituted Complex Homo sapiens
5 CXCL12 6387
Reconstituted Complex Homo sapiens
6 CXCL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CCL11  
Reconstituted Complex Homo sapiens
8 CXCL14  
Reconstituted Complex Homo sapiens
9 EPS8 2059
Two-hybrid Homo sapiens
10 CCL5 6352
Reconstituted Complex Homo sapiens
11 XCL1  
Reconstituted Complex Homo sapiens
12 DUSP3 1845
Affinity Capture-MS Homo sapiens
13 XCL2  
Reconstituted Complex Homo sapiens
14 CCL21  
Reconstituted Complex Homo sapiens
15 COPS5 10987
Affinity Capture-MS Homo sapiens
16 CXCL9  
Reconstituted Complex Homo sapiens
17 COA3 28958
Affinity Capture-MS Homo sapiens
18 PIK3R1 5295
Two-hybrid Homo sapiens
19 RC3H1 149041
Affinity Capture-RNA Homo sapiens
20 CXCL11  
Reconstituted Complex Homo sapiens
21 CCL28 56477
Reconstituted Complex Homo sapiens
22 PF4 5196
Reconstituted Complex Homo sapiens
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