Gene description for FGD2
Gene name FYVE, RhoGEF and PH domain containing 2
Gene symbol FGD2
Other names/aliases ZFYVE4
Species Homo sapiens
 Database cross references - FGD2
ExoCarta ExoCarta_221472
Vesiclepedia VP_221472
Entrez Gene 221472
HGNC 3664
MIM 605091
UniProt Q7Z6J4  
 FGD2 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FGD2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 ISS
    metal ion binding GO:0046872 IEA
    phosphatidylinositol phosphate binding GO:1901981 IEA
Biological Process
    cytoskeleton organization GO:0007010 IBA
    cytoskeleton organization GO:0007010 ISS
    regulation of cell shape GO:0008360 ISS
    actin cytoskeleton organization GO:0030036 ISS
    regulation of GTPase activity GO:0043087 ISS
    filopodium assembly GO:0046847 IBA
    filopodium assembly GO:0046847 ISS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
Subcellular Localization
    ruffle GO:0001726 ISS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    Golgi apparatus GO:0005794 ISS
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    lamellipodium GO:0030027 ISS
    early endosome membrane GO:0031901 IEA
    ruffle membrane GO:0032587 IEA
 Experiment description of studies that identified FGD2 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FGD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMGN3  
Affinity Capture-MS Homo sapiens
2 TMEM239  
Two-hybrid Homo sapiens
3 RPRM  
Two-hybrid Homo sapiens
4 FBXL7  
Affinity Capture-MS Homo sapiens
5 PKP2 5318
Affinity Capture-MS Homo sapiens
6 TCERG1 10915
Affinity Capture-MS Homo sapiens
7 HMGN5 79366
Affinity Capture-MS Homo sapiens
8 UBC 7316
Affinity Capture-MS Homo sapiens
9 CSTA 1475
Affinity Capture-MS Homo sapiens
10 TMEM263 90488
Affinity Capture-MS Homo sapiens
11 CAND1 55832
Affinity Capture-MS Homo sapiens
12 RBM15 64783
Affinity Capture-MS Homo sapiens
13 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
14 Arhgap15  
Affinity Capture-MS Mus musculus
15 CDC42 998
FRET Homo sapiens
16 MRPS28  
Affinity Capture-MS Homo sapiens
17 PLEKHG4  
Two-hybrid Homo sapiens
18 SDF2L1 23753
Affinity Capture-MS Homo sapiens
19 HMGN1  
Affinity Capture-MS Homo sapiens
20 HP1BP3 50809
Affinity Capture-MS Homo sapiens
21 RPS27L 51065
Affinity Capture-MS Homo sapiens
22 PIK3R1 5295
Affinity Capture-MS Homo sapiens
23 MCM6 4175
Affinity Capture-MS Homo sapiens
24 KLHL12  
Two-hybrid Homo sapiens
View the network image/svg+xml



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