Gene description for NTRK2
Gene name	neurotrophic tyrosine kinase, receptor, type 2
Gene symbol	NTRK2
Other names/aliases	GP145-TrkB TRKB trk-B
Species	Homo sapiens
Database cross references - NTRK2
ExoCarta	ExoCarta_4915
Vesiclepedia	VP_4915
Entrez Gene	4915
HGNC	8032
MIM	600456
UniProt	Q16620
NTRK2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for NTRK2

Molecular Function     protease binding GO:0002020 IPI     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     protein homodimerization activity GO:0042803 ISS     neurotrophin binding GO:0043121 IDA     neurotrophin binding GO:0043121 ISS     brain-derived neurotrophic factor binding GO:0048403 IBA     brain-derived neurotrophic factor binding GO:0048403 ISS     brain-derived neurotrophic factor receptor activity GO:0060175 IBA     brain-derived neurotrophic factor receptor activity GO:0060175 IMP     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     vasculogenesis GO:0001570 IEA     neuron migration GO:0001764 ISS     positive regulation of protein phosphorylation GO:0001934 TAS     chromatin remodeling GO:0006338 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     learning GO:0007612 ISS     circadian rhythm GO:0007623 IEA     feeding behavior GO:0007631 IEA     positive regulation of cell population proliferation GO:0008284 ISS     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     positive regulation of gene expression GO:0010628 ISS     positive regulation of neuron projection development GO:0010976 IBA     positive regulation of neuron projection development GO:0010976 ISS     glutamate secretion GO:0014047 IEA     neuronal action potential propagation GO:0019227 IEA     central nervous system neuron development GO:0021954 ISS     cerebral cortex development GO:0021987 ISS     myelination in peripheral nervous system GO:0022011 IEA     neuron differentiation GO:0030182 ISS     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IMP     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 TAS     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     neurotrophin signaling pathway GO:0038179 IEA     mechanoreceptor differentiation GO:0042490 IEA     regulation of GTPase activity GO:0043087 ISS     positive regulation of MAPK cascade GO:0043410 ISS     negative regulation of neuron apoptotic process GO:0043524 ISS     retinal rod cell development GO:0046548 IEA     protein autophosphorylation GO:0046777 ISS     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     oligodendrocyte differentiation GO:0048709 IEA     peripheral nervous system neuron development GO:0048935 IEA     positive regulation of axonogenesis GO:0050772 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     positive regulation of synapse assembly GO:0051965 IEA     long-term synaptic potentiation GO:0060291 IEA     cellular response to amino acid stimulus GO:0071230 IEA     trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 IEA     trans-synaptic signaling by neuropeptide, modulating synaptic transmission GO:0099551 IBA     negative regulation of amyloid-beta formation GO:1902430 IGI     cellular response to brain-derived neurotrophic factor stimulus GO:1990416 IBA     negative regulation of anoikis GO:2000811 IEA Subcellular Localization     early endosome GO:0005769 ISS     cytosol GO:0005829 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     postsynaptic density GO:0014069 IBA     postsynaptic density GO:0014069 ISS     axon GO:0030424 IBA     axon GO:0030424 ISS     dendrite GO:0030425 ISS     early endosome membrane GO:0031901 IEA     terminal bouton GO:0043195 IEA     dendritic spine GO:0043197 IBA     receptor complex GO:0043235 IBA     receptor complex GO:0043235 IDA     axon terminus GO:0043679 IBA     perinuclear region of cytoplasm GO:0048471 ISS