Gene description for RMDN1
Gene name regulator of microtubule dynamics 1
Gene symbol RMDN1
Other names/aliases CGI-90
FAM82B
RMD-1
RMD1
Species Homo sapiens
 Database cross references - RMDN1
ExoCarta ExoCarta_51115
Vesiclepedia VP_51115
Entrez Gene 51115
HGNC 24285
MIM 611871
UniProt Q96DB5  
 RMDN1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RMDN1
Molecular Function
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IDA
Biological Process
    mitotic spindle organization GO:0007052 ISS
    attachment of mitotic spindle microtubules to kinetochore GO:0051315 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    spindle microtubule GO:0005876 IBA
    spindle microtubule GO:0005876 IDA
    mitotic spindle pole GO:0097431 IBA
    mitotic spindle pole GO:0097431 IDA
 Experiment description of studies that identified RMDN1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RMDN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 WIF1 11197
Affinity Capture-MS Homo sapiens
3 PAQR3  
Affinity Capture-MS Homo sapiens
4 NIPA2 81614
Affinity Capture-MS Homo sapiens
5 S100P 6286
Affinity Capture-MS Homo sapiens
6 MINOS1  
Affinity Capture-MS Homo sapiens
7 MUM1  
Affinity Capture-MS Homo sapiens
8 C10orf107  
Affinity Capture-MS Homo sapiens
9 TP53 7157
Synthetic Growth Defect Homo sapiens
10 HIST2H3C 126961
Affinity Capture-MS Homo sapiens
11 S100A6 6277
Affinity Capture-MS Homo sapiens
12 CD300E  
Affinity Capture-MS Homo sapiens
13 XPA  
Affinity Capture-MS Homo sapiens
14 SYT6  
Affinity Capture-MS Homo sapiens
15 TOP3B 8940
Affinity Capture-MS Homo sapiens
16 SUZ12  
Affinity Capture-MS Homo sapiens
17 ECHDC1 55862
Co-fractionation Homo sapiens
18 STAU1 6780
Co-fractionation Homo sapiens
19 CDK2 1017
Affinity Capture-MS Homo sapiens
20 PDLIM5 10611
Affinity Capture-MS Homo sapiens
21 EZH2  
Affinity Capture-MS Homo sapiens
22 MTF2  
Affinity Capture-MS Homo sapiens
23 RPA2 6118
Co-fractionation Homo sapiens
24 DDB1 1642
Affinity Capture-MS Homo sapiens
25 SAR1B 51128
Affinity Capture-MS Homo sapiens
26 CYP2E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CENPM  
Affinity Capture-MS Homo sapiens
28 SERBP1 26135
Affinity Capture-MS Homo sapiens
29 VKORC1 79001
Two-hybrid Homo sapiens
30 Junb  
Affinity Capture-MS Mus musculus
31 RPA3 6119
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
32 CHIT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NTNG1  
Affinity Capture-MS Homo sapiens
34 Myh9 17886
Affinity Capture-MS Mus musculus
35 EED  
Affinity Capture-MS Homo sapiens
36 H2AFX 3014
Affinity Capture-MS Homo sapiens
37 SHC1 6464
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which RMDN1 is involved
No pathways found





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