Gene description for JAK3
Gene name	Janus kinase 3
Gene symbol	JAK3
Other names/aliases	JAK-3 JAK3_HUMAN JAKL L-JAK LJAK
Species	Homo sapiens
Database cross references - JAK3
ExoCarta	ExoCarta_3718
Vesiclepedia	VP_3718
Entrez Gene	3718
HGNC	6193
MIM	600173
UniProt	P52333
JAK3 identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for JAK3

Molecular Function     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 IMP     protein tyrosine kinase activity GO:0004713 ISS     protein tyrosine kinase activity GO:0004713 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     growth hormone receptor binding GO:0005131 IBA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     protein phosphatase binding GO:0019903 IPI     histone H3Y41 kinase activity GO:0035401 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     adaptive immune response GO:0002250 IEA     negative regulation of dendritic cell cytokine production GO:0002731 ISS     chromatin remodeling GO:0006338 IEA     enzyme-linked receptor protein signaling pathway GO:0007167 ISS     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IBA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 NAS     tyrosine phosphorylation of STAT protein GO:0007260 TAS     cytokine-mediated signaling pathway GO:0019221 IBA     cell differentiation GO:0030154 IBA     B cell differentiation GO:0030183 ISS     negative regulation of interleukin-10 production GO:0032693 ISS     negative regulation of interleukin-12 production GO:0032695 ISS     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 ISS     interleukin-15-mediated signaling pathway GO:0035723 IDA     interleukin-4-mediated signaling pathway GO:0035771 IDA     interleukin-4-mediated signaling pathway GO:0035771 NAS     interleukin-2-mediated signaling pathway GO:0038110 IDA     interleukin-2-mediated signaling pathway GO:0038110 TAS     interleukin-7-mediated signaling pathway GO:0038111 IDA     interleukin-9-mediated signaling pathway GO:0038113 IDA     regulation of apoptotic process GO:0042981 IBA     T cell homeostasis GO:0043029 ISS     T cell homeostasis GO:0043029 TAS     innate immune response GO:0045087 IEA     negative regulation of FasL production GO:0045221 ISS     negative regulation of T-helper 1 cell differentiation GO:0045626 ISS     regulation of receptor signaling pathway via JAK-STAT GO:0046425 TAS     negative regulation of T cell activation GO:0050868 ISS     growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IBA     growth hormone receptor signaling pathway via JAK-STAT GO:0060397 TAS     regulation of T cell apoptotic process GO:0070232 ISS     negative regulation of thymocyte apoptotic process GO:0070244 ISS     response to interleukin-2 GO:0070669 TAS     response to interleukin-4 GO:0070670 IDA     response to interleukin-15 GO:0070672 TAS     response to interleukin-9 GO:0071104 TAS     negative regulation of T-helper 17 cell lineage commitment GO:2000329 IDA Subcellular Localization     endosome GO:0005768 TAS     cytosol GO:0005829 IBA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 TAS     cytoplasmic side of plasma membrane GO:0009898 IC     extrinsic component of plasma membrane GO:0019897 IC     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IC     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA