Gene description for LEPR
Gene name	leptin receptor
Gene symbol	LEPR
Other names/aliases	CD295 LEP-R LEPRD OB-R OBR
Species	Homo sapiens
Database cross references - LEPR
ExoCarta	ExoCarta_3953
Vesiclepedia	VP_3953
Entrez Gene	3953
HGNC	6554
MIM	601007
UniProt	P48357
LEPR identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for LEPR

Molecular Function     transmembrane signaling receptor activity GO:0004888 TAS     cytokine receptor activity GO:0004896 IBA     protein binding GO:0005515 IPI     cytokine binding GO:0019955 IBA     leptin receptor activity GO:0038021 IDA     leptin receptor activity GO:0038021 ISS     identical protein binding GO:0042802 IPI Biological Process     angiogenesis GO:0001525 IMP     positive regulation of protein phosphorylation GO:0001934 IDA     glycogen metabolic process GO:0005977 IEA     gluconeogenesis GO:0006094 IEA     energy reserve metabolic process GO:0006112 TAS     phagocytosis GO:0006909 IEA     cell surface receptor signaling pathway GO:0007166 TAS     multicellular organism development GO:0007275 TAS     cholesterol metabolic process GO:0008203 IEA     positive regulation of cell population proliferation GO:0008284 IBA     negative regulation of autophagy GO:0010507 IDA     glial cell proliferation GO:0014009 IEA     cytokine-mediated signaling pathway GO:0019221 IBA     sexual reproduction GO:0019953 ISS     T cell differentiation GO:0030217 ISS     leptin-mediated signaling pathway GO:0033210 IDA     leptin-mediated signaling pathway GO:0033210 ISS     glucose homeostasis GO:0042593 ISS     response to leptin GO:0044321 ISS     negative regulation of gluconeogenesis GO:0045721 IEA     regulation of bone remodeling GO:0046850 ISS     regulation of transport GO:0051049 IDA     regulation of feeding behavior GO:0060259 ISS     energy homeostasis GO:0097009 ISS     bone growth GO:0098868 ISS     positive regulation of cold-induced thermogenesis GO:0120162 ISS     transport across blood-brain barrier GO:0150104 NAS Subcellular Localization     extracellular region GO:0005576 IEA     external side of plasma membrane GO:0009897 IBA     basolateral plasma membrane GO:0016323 IEA     receptor complex GO:0043235 IBA     receptor complex GO:0043235 IDA