Gene description for IGF2
Gene name	insulin-like growth factor 2
Gene symbol	IGF2
Other names/aliases	C11orf43 IGF-II PP9974
Species	Homo sapiens
Database cross references - IGF2
ExoCarta	ExoCarta_3481
Vesiclepedia	VP_3481
Entrez Gene	3481
HGNC	5466
MIM	147470
UniProt	P01344
IGF2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Prostate cancer cells	25844599

Gene ontology annotations for IGF2

Molecular Function     insulin receptor binding GO:0005158 IPI     insulin-like growth factor receptor binding GO:0005159 IBA     insulin-like growth factor receptor binding GO:0005159 IMP     integrin binding GO:0005178 IDA     hormone activity GO:0005179 IEA     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IBA     growth factor activity GO:0008083 IDA     transmembrane receptor protein tyrosine kinase activator activity GO:0030297 IDA     protein serine/threonine kinase activator activity GO:0043539 IBA     protein serine/threonine kinase activator activity GO:0043539 ISS     receptor ligand activity GO:0048018 ISS Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     osteoblast differentiation GO:0001649 IEA     in utero embryonic development GO:0001701 ISS     embryonic placenta development GO:0001892 ISS     glucose metabolic process GO:0006006 IEA     regulation of DNA-templated transcription GO:0006355 NAS     positive regulation of cell population proliferation GO:0008284 IC     positive regulation of cell population proliferation GO:0008284 IDA     insulin receptor signaling pathway GO:0008286 ISS     animal organ morphogenesis GO:0009887 IEA     exocrine pancreas development GO:0031017 IEA     positive regulation of multicellular organism growth GO:0040018 IEA     positive regulation of activated T cell proliferation GO:0042104 IBA     positive regulation of activated T cell proliferation GO:0042104 IDA     positive regulation of MAPK cascade GO:0043410 IBA     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of glycogen biosynthetic process GO:0045725 ISS     positive regulation of mitotic nuclear division GO:0045840 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of organ growth GO:0046622 IEA     positive regulation of insulin receptor signaling pathway GO:0046628 IBA     positive regulation of insulin receptor signaling pathway GO:0046628 IDA     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     positive regulation of skeletal muscle tissue growth GO:0048633 IEA     striated muscle cell differentiation GO:0051146 IEA     regulation of muscle cell differentiation GO:0051147 IBA     regulation of muscle cell differentiation GO:0051147 ISS     negative regulation of muscle cell differentiation GO:0051148 ISS     positive regulation of cell division GO:0051781 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     embryonic placenta morphogenesis GO:0060669 ISS     genomic imprinting GO:0071514 TAS     positive regulation of vascular endothelial cell proliferation GO:1905564 IBA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     platelet alpha granule lumen GO:0031093 TAS