Gene description for STAB2
Gene name stabilin 2
Gene symbol STAB2
Other names/aliases FEEL2
FELE-2
FELL2
FEX2
HARE
Species Homo sapiens
 Database cross references - STAB2
ExoCarta ExoCarta_55576
Vesiclepedia VP_55576
Entrez Gene 55576
HGNC 18629
MIM 608561
UniProt Q8WWQ8  
 STAB2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for STAB2
Molecular Function
    low-density lipoprotein particle receptor activity GO:0005041 IBA
    low-density lipoprotein particle receptor activity GO:0005041 IDA
    scavenger receptor activity GO:0005044 IDA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    hyaluronic acid binding GO:0005540 ISS
    protein-disulfide reductase activity GO:0015035 NAS
    low-density lipoprotein particle binding GO:0030169 IBA
    low-density lipoprotein particle binding GO:0030169 IDA
Biological Process
    angiogenesis GO:0001525 NAS
    endocytosis GO:0006897 ISS
    receptor-mediated endocytosis GO:0006898 TAS
    cell adhesion GO:0007155 NAS
    hyaluronan catabolic process GO:0030214 IEA
    defense response to bacterium GO:0042742 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 ISS
    endocytic vesicle membrane GO:0030666 TAS
 Experiment description of studies that identified STAB2 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for STAB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 PIAS1 8554
Affinity Capture-Western Homo sapiens
3 MAPK8 5599
Affinity Capture-Western Homo sapiens
4 MAPK14 1432
Affinity Capture-Western Homo sapiens
5 MAPK3 5595
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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