Gene description for SATB1
Gene name SATB homeobox 1
Gene symbol SATB1
Other names/aliases -
Species Homo sapiens
 Database cross references - SATB1
ExoCarta ExoCarta_6304
Vesiclepedia VP_6304
Entrez Gene 6304
HGNC 10541
MIM 602075
UniProt Q01826  
 SATB1 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Thymus 23844026    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SATB1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    double-stranded DNA binding GO:0003690 TAS
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    chromatin organization GO:0006325 TAS
    chromatin remodeling GO:0006338 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nuclear matrix GO:0016363 IEA
    nuclear body GO:0016604 IDA
    PML body GO:0016605 IDA
 Experiment description of studies that identified SATB1 in sEVs
1
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 193
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SATB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOXF1 2294
Affinity Capture-MS Homo sapiens
2 FOXA1  
Affinity Capture-MS Homo sapiens
3 HDAC2 3066
Co-fractionation Homo sapiens
4 IRF4  
Proximity Label-MS Homo sapiens
5 FEV  
Proximity Label-MS Homo sapiens
6 SCYL1 57410
Affinity Capture-MS Homo sapiens
7 FOXD3  
Affinity Capture-MS Homo sapiens
8 LHX2  
Proximity Label-MS Homo sapiens
9 NFATC1 4772
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
10 PRSS3 5646
Affinity Capture-MS Homo sapiens
11 RBM12 10137
Affinity Capture-MS Homo sapiens
12 SOX2  
Proximity Label-MS Homo sapiens
13 SATB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 S100A4 6275
Affinity Capture-MS Homo sapiens
15 ZMIZ1 57178
Affinity Capture-MS Homo sapiens
16 PAX9  
Proximity Label-MS Homo sapiens
17 CUX1 1523
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
18 TEAD1  
Proximity Label-MS Homo sapiens
19 LHX4  
Proximity Label-MS Homo sapiens
20 SOX5 6660
Proximity Label-MS Homo sapiens
21 FOXP3  
Affinity Capture-MS Homo sapiens
22 MTA2 9219
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
23 RBPJ 3516
Affinity Capture-MS Homo sapiens
24 FOXP1 27086
Affinity Capture-MS Homo sapiens
25 S100A2 6273
Affinity Capture-MS Homo sapiens
26 FOXC1  
Affinity Capture-MS Homo sapiens
27 Prkca  
Biochemical Activity Rattus norvegicus
28 TLX3  
Proximity Label-MS Homo sapiens
29 QPRT 23475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CTBP1 1487
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
31 PIAS4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 UBE2I 7329
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 LHX1  
Proximity Label-MS Homo sapiens
34 RPA2 6118
Proximity Label-MS Homo sapiens
35 UBR5 51366
Two-hybrid Homo sapiens
36 CASP6 839
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 FOXC2  
Affinity Capture-MS Homo sapiens
38 TEAD2  
Affinity Capture-MS Homo sapiens
39 MEOX2  
Two-hybrid Homo sapiens
40 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
41 GATA2  
Proximity Label-MS Homo sapiens
42 T  
Proximity Label-MS Homo sapiens
43 FOXS1  
Affinity Capture-MS Homo sapiens
44 VSX1  
Proximity Label-MS Homo sapiens
45 GATA3  
Proximity Label-MS Homo sapiens
46 CCNO  
Affinity Capture-MS Homo sapiens
47 TLX2  
Proximity Label-MS Homo sapiens
48 PAX6  
Proximity Label-MS Homo sapiens
49 SOX6  
Proximity Label-MS Homo sapiens
50 SMARCA5 8467
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
51 TAL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 CTNNB1 1499
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 SRSF1 6426
Affinity Capture-MS Homo sapiens
54 FOXO1  
Affinity Capture-MS Homo sapiens
55 FOXI1  
Proximity Label-MS Homo sapiens
56 FOXG1  
Affinity Capture-MS Homo sapiens
57 FOXL1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
58 USP47 55031
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
59 TGM7  
Affinity Capture-MS Homo sapiens
60 SOX15  
Proximity Label-MS Homo sapiens
61 JUN 3725
Affinity Capture-MS Homo sapiens
62 PIAS1 8554
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
63 RPA3 6119
Proximity Label-MS Homo sapiens
64 PIAS3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 ETV3  
Proximity Label-MS Homo sapiens
66 BAZ1A 11177
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
67 FOXQ1  
Affinity Capture-MS Homo sapiens
68 SUMO1P1  
Two-hybrid Homo sapiens
69 P4HA3 283208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 NFATC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
71 PYHIN1  
Affinity Capture-MS Homo sapiens
72 SUMO1 7341
Two-hybrid Homo sapiens
73 PROSC 11212
Affinity Capture-MS Homo sapiens
74 CBX4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
75 MAGEA8  
Affinity Capture-MS Homo sapiens
76 TLX1  
Proximity Label-MS Homo sapiens
77 ELF5  
Proximity Label-MS Homo sapiens
78 POLR2J  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
79 SIN3A  
Co-fractionation Homo sapiens
80 FOXB1  
Affinity Capture-MS Homo sapiens
81 KAT2B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
82 TLE1 7088
Affinity Capture-MS Homo sapiens
83 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
84 FOXN1  
Affinity Capture-MS Homo sapiens
85 MAGEA9  
Affinity Capture-MS Homo sapiens
86 SIRT1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
87 PAX7  
Proximity Label-MS Homo sapiens
88 TOPORS  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
89 HNF1B  
Proximity Label-MS Homo sapiens
90 SMURF2 64750
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
91 FOXE1  
Affinity Capture-MS Homo sapiens
92 SP7  
Proximity Label-MS Homo sapiens
93 EP300 2033
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
94 TRIM47 91107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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