Gene description for TFAP2C
Gene name transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Gene symbol TFAP2C
Other names/aliases AP2-GAMMA
ERF1
TFAP2G
hAP-2g
Species Homo sapiens
 Database cross references - TFAP2C
ExoCarta ExoCarta_7022
Vesiclepedia VP_7022
Entrez Gene 7022
HGNC 11744
MIM 601602
UniProt Q92754  
 TFAP2C identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TFAP2C
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    cell-cell signaling GO:0007267 TAS
    male gonad development GO:0008584 IEP
    regulation of cell population proliferation GO:0042127 IBA
    negative regulation of gene expression, epigenetic GO:0045814 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TFAP2C in sEVs
1
Experiment ID 235
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TFAP2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASF1A 25842
Co-localization Homo sapiens
2 TP53 7157
Reconstituted Complex Homo sapiens
3 ZFAND4  
Two-hybrid Homo sapiens
4 WWOX 51741
Reconstituted Complex Homo sapiens
5 TFAP2A  
Affinity Capture-Western Homo sapiens
6 BRCA1 672
Affinity Capture-Western Homo sapiens
7 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
8 ERBB4 2066
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 EGFR 1956
Negative Genetic Homo sapiens
10 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
11 SREBF2 6721
Positive Genetic Homo sapiens
12 CITED4  
Reconstituted Complex Homo sapiens
13 UBE2I 7329
Two-hybrid Homo sapiens
14 ESR1  
Affinity Capture-MS Homo sapiens
15 NR1I2  
Two-hybrid Homo sapiens
16 MYC  
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
17 CITED2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
18 AIM2  
Affinity Capture-MS Homo sapiens
19 KDM5B  
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
20 TFAP2D  
Affinity Capture-MS Homo sapiens
21 HIRA  
Co-localization Homo sapiens
22 KCTD1 284252
Affinity Capture-Western Homo sapiens
23 CCNG1  
Two-hybrid Homo sapiens
24 UBN1  
Co-localization Homo sapiens
25 IKBKB 3551
Two-hybrid Homo sapiens
26 GPR22  
Two-hybrid Homo sapiens
27 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TFAP2C is involved
PathwayEvidenceSource
Activation of the TFAP2 (AP-2) family of transcription factors TAS Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Gastrulation IEA Reactome
Gastrulation TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
Metabolism of proteins TAS Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors TAS Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors IEA Reactome
Post-translational protein modification TAS Reactome
Reproduction TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
Specification of primordial germ cells TAS Reactome
Specification of the neural plate border IEA Reactome
Specification of the neural plate border TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMOylation TAS Reactome
SUMOylation of transcription factors TAS Reactome
TFAP2 (AP-2) family regulates transcription of cell cycle factors TAS Reactome
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TAS Reactome
TFAP2 (AP-2) family regulates transcription of other transcription factors TAS Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TAS Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors IEA Reactome





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