Gene description for ATAD2B
Gene name ATPase family, AAA domain containing 2B
Gene symbol ATAD2B
Other names/aliases -
Species Homo sapiens
 Database cross references - ATAD2B
ExoCarta ExoCarta_54454
Vesiclepedia VP_54454
Entrez Gene 54454
HGNC 29230
MIM 615347
UniProt Q9ULI0  
 ATAD2B identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ATAD2B
Molecular Function
    chromatin binding GO:0003682 IBA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IBA
    histone binding GO:0042393 IBA
    lysine-acetylated histone binding GO:0070577 IDA
Biological Process
    nucleosome assembly GO:0006334 IBA
    nucleosome disassembly GO:0006337 IBA
    transcription initiation-coupled chromatin remodeling GO:0045815 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ATAD2B in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ATAD2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIRT7  
Affinity Capture-MS Homo sapiens
2 CSNK2B 1460
Affinity Capture-MS Homo sapiens
3 HMGN5 79366
Affinity Capture-MS Homo sapiens
4 MB21D1  
Proximity Label-MS Homo sapiens
5 NUMA1 4926
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATAD2B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here