Gene description for RREB1
Gene name ras responsive element binding protein 1
Gene symbol RREB1
Other names/aliases FINB
HNT
LZ321
RREB-1
Zep-1
Species Homo sapiens
 Database cross references - RREB1
ExoCarta ExoCarta_6239
Vesiclepedia VP_6239
Entrez Gene 6239
HGNC 10449
MIM 602209
UniProt Q92766  
 RREB1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Urine 19056867    
 Gene ontology annotations for RREB1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    regulation of DNA-templated transcription GO:0006355 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    transcription by RNA polymerase II GO:0006366 TAS
    positive regulation of epithelial cell migration GO:0010634 IMP
    positive regulation of mammary gland epithelial cell proliferation GO:0033601 IMP
    positive regulation of DNA-templated transcription GO:0045893 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of brown fat cell differentiation GO:0090336 ISS
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP
    positive regulation of wound healing, spreading of epidermal cells GO:1903691 IMP
    positive regulation of lamellipodium morphogenesis GO:2000394 IMP
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 TAS
    cytoplasm GO:0005737 TAS
    nuclear body GO:0016604 TAS
    nuclear speck GO:0016607 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified RREB1 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for RREB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 HIST3H3 8290
Biochemical Activity Homo sapiens
3 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
4 SOX7  
Proximity Label-MS Homo sapiens
5 TLX1  
Proximity Label-MS Homo sapiens
6 SNCA 6622
Affinity Capture-MS Homo sapiens
7 PAX6  
Proximity Label-MS Homo sapiens
8 ASF1A 25842
Proximity Label-MS Homo sapiens
9 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZMYND8 23613
Affinity Capture-MS Homo sapiens
11 ZNF66  
Proximity Label-MS Homo sapiens
12 COIL  
Proximity Label-MS Homo sapiens
13 Cdc23  
Affinity Capture-MS Mus musculus
14 TP53 7157
Affinity Capture-MS Homo sapiens
15 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
16 BAG2 9532
Affinity Capture-MS Homo sapiens
17 ELK3  
Proximity Label-MS Homo sapiens
18 ZNF217 7764
Co-fractionation Homo sapiens
19 LHX2  
Proximity Label-MS Homo sapiens
20 DHX40  
Proximity Label-MS Homo sapiens
21 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
22 KLF3  
Proximity Label-MS Homo sapiens
23 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
24 HNF4A  
Proximity Label-MS Homo sapiens
25 RFX1  
Proximity Label-MS Homo sapiens
26 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CTBP1 1487
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
28 PIAS4  
Affinity Capture-MS Homo sapiens
29 SPATA20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 Ppp4c 56420
Affinity Capture-MS Mus musculus
31 BLM 641
Synthetic Growth Defect Homo sapiens
32 KLF16  
Proximity Label-MS Homo sapiens
33 CENPA  
Proximity Label-MS Homo sapiens
34 NFIX 4784
Proximity Label-MS Homo sapiens
35 KLF12  
Proximity Label-MS Homo sapiens
36 APEX1 328
Proximity Label-MS Homo sapiens
37 NEK7 140609
Affinity Capture-MS Homo sapiens
38 CBX3 11335
Proximity Label-MS Homo sapiens
39 PAX7  
Proximity Label-MS Homo sapiens
40 NAPA 8775
Affinity Capture-MS Homo sapiens
41 KDM1A 23028
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
42 RPA3 6119
Proximity Label-MS Homo sapiens
43 KLF8  
Proximity Label-MS Homo sapiens
44 AIM2  
Affinity Capture-MS Homo sapiens
45 Snw1  
Affinity Capture-MS Mus musculus
46 CIT 11113
Affinity Capture-MS Homo sapiens
47 HSPA1A 3303
Co-fractionation Homo sapiens
48 NUBP1 4682
Affinity Capture-MS Homo sapiens
49 ARL6 84100
Affinity Capture-MS Homo sapiens
50 PARP1 142
Proximity Label-MS Homo sapiens
51 NFIC 4782
Proximity Label-MS Homo sapiens
52 AR 367
Affinity Capture-Western Homo sapiens
53 POLR1E  
Proximity Label-MS Homo sapiens
54 TEAD1  
Proximity Label-MS Homo sapiens
55 RCOR1  
Affinity Capture-MS Homo sapiens
56 CEBPA  
Proximity Label-MS Homo sapiens
57 PYHIN1  
Affinity Capture-MS Homo sapiens
58 VSX1  
Proximity Label-MS Homo sapiens
59 TEX19  
Affinity Capture-MS Homo sapiens
60 C17orf53  
Proximity Label-MS Homo sapiens
61 FEV  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RREB1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here