Gene description for ZNF217
Gene name zinc finger protein 217
Gene symbol ZNF217
Other names/aliases ZABC1
Species Homo sapiens
 Database cross references - ZNF217
ExoCarta ExoCarta_7764
Vesiclepedia VP_7764
Entrez Gene 7764
HGNC 13009
MIM 602967
UniProt O75362  
 ZNF217 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for ZNF217
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
Subcellular Localization
    histone deacetylase complex GO:0000118 IDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    mitochondrion GO:0005739 IDA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified ZNF217 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ZNF217
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RREB1 6239
Co-fractionation Homo sapiens
2 HMG20B  
Co-fractionation Homo sapiens
3 ZMYM2  
Co-fractionation Homo sapiens
4 TLX1  
Proximity Label-MS Homo sapiens
5 IKBKAP 8518
Co-fractionation Homo sapiens
6 PHF1  
Affinity Capture-MS Homo sapiens
7 KIF1B 23095
Affinity Capture-MS Homo sapiens
8 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
9 RCOR3  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
10 AHCY 191
Affinity Capture-MS Homo sapiens
11 PRKRIP1 79706
Co-fractionation Homo sapiens
12 FEV  
Proximity Label-MS Homo sapiens
13 KDM5B  
Affinity Capture-MS Homo sapiens
14 NFIX 4784
Proximity Label-MS Homo sapiens
15 HSPA8 3312
Affinity Capture-MS Homo sapiens
16 SOX6  
Proximity Label-MS Homo sapiens
17 CTBP2 1488
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
18 ELK3  
Proximity Label-MS Homo sapiens
19 MCM6 4175
Co-fractionation Homo sapiens
20 CALU 813
Affinity Capture-MS Homo sapiens
21 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
22 MEX3A  
Affinity Capture-RNA Homo sapiens
23 KLF3  
Proximity Label-MS Homo sapiens
24 HMG20A  
Co-fractionation Homo sapiens
25 SAP30 8819
Co-fractionation Homo sapiens
26 EMD 2010
Affinity Capture-MS Homo sapiens
27 HINT1 3094
Co-fractionation Homo sapiens
28 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
29 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
30 CTBP1 1487
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
31 PAX9  
Proximity Label-MS Homo sapiens
32 COPA 1314
Co-fractionation Homo sapiens
33 TBR1  
Proximity Label-MS Homo sapiens
34 HIST3H3 8290
Biochemical Activity Homo sapiens
35 DNTTIP1 116092
Co-fractionation Homo sapiens
36 ESR1  
Affinity Capture-MS Homo sapiens
37 RCOR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
38 ZMYM3  
Co-fractionation Homo sapiens
39 EFTUD2 9343
Affinity Capture-MS Homo sapiens
40 CBX3 11335
Proximity Label-MS Homo sapiens
41 GTF2I 2969
Co-fractionation Homo sapiens
42 PAX7  
Proximity Label-MS Homo sapiens
43 TRIM37  
Proximity Label-MS Homo sapiens
44 KDM1A 23028
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
45 SREBF2 6721
Negative Genetic Homo sapiens
46 HDAC6 10013
Co-fractionation Homo sapiens
47 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
48 GSE1 23199
Co-fractionation Homo sapiens
49 DDX5 1655
Affinity Capture-MS Homo sapiens
50 KLF8  
Proximity Label-MS Homo sapiens
51 MCM2 4171
Co-fractionation Homo sapiens
52 DCAF7 10238
Proximity Label-MS Homo sapiens
53 UBALD2  
Affinity Capture-MS Homo sapiens
54 EHMT2 10919
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
55 HSPA1A 3303
Co-fractionation Homo sapiens
56 PPP2CA 5515
Affinity Capture-MS Homo sapiens
57 PIPOX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 EHMT1  
Co-fractionation Homo sapiens
59 RCN2 5955
Affinity Capture-MS Homo sapiens
60 HNF1B  
Proximity Label-MS Homo sapiens
61 AR 367
Proximity Label-MS Homo sapiens
62 EWSR1 2130
Affinity Capture-MS Homo sapiens
63 VIM 7431
Affinity Capture-MS Homo sapiens
64 FBXO38 81545
Proximity Label-MS Homo sapiens
65 SP7  
Proximity Label-MS Homo sapiens
66 NFATC2  
Affinity Capture-MS Homo sapiens
67 TEAD1  
Proximity Label-MS Homo sapiens
68 KLF12  
Proximity Label-MS Homo sapiens
69 CEBPA  
Proximity Label-MS Homo sapiens
70 RBBP8  
Affinity Capture-MS Homo sapiens
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