Experiment description of studies that identified RLF in sEVs

1 Experiment ID 226 MISEV standards ✔ Biophysical techniques ✔ Enriched markers ✔ Negative markers ✘ Particle analysis Identified molecule mRNA Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa) PubMed ID 26027894     Organism Homo sapiens Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting" Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar" Journal name Journal of Extracellular Vesicles Publication year 2015 Sample Endothelial cells Sample name HMEC-1 Isolation/purification methods Differential ultracentrifugation Sucrose density gradient Flotation density 1.10 g/mL Molecules identified in the study miRNA Protein snoRNA lncRNA yRNA snRNA mRNA ncRNA mtRNA vtRNA scaRNA lincRNA Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa) Western blotting

Protein-protein interactions for RLF

Protein Interactor ExoCarta ID Identification method PubMed Species 1 ZNF644   Affinity Capture-MS Homo sapiens 2 Cbx1   Affinity Capture-MS Mus musculus 3 RIT1 6016 Reconstituted Complex Homo sapiens 4 NUMA1 4926 Affinity Capture-MS Homo sapiens 5 PLEKHA4 57664 Affinity Capture-MS Homo sapiens 6 FASN 2194 Negative Genetic Homo sapiens 7 CBX1 10951 Affinity Capture-MS Homo sapiens 8 ZNF280D   Affinity Capture-MS Homo sapiens 9 PARP1 142 Proximity Label-MS Homo sapiens 10 HIST1H3A 8350 Proximity Label-MS Homo sapiens 11 COIL   Proximity Label-MS Homo sapiens 12 FEV   Proximity Label-MS Homo sapiens 13 NFIB   Proximity Label-MS Homo sapiens 14 HIST2H2BE 8349 Affinity Capture-MS Homo sapiens 15 KLF9 687 Proximity Label-MS Homo sapiens 16 KLF16   Proximity Label-MS Homo sapiens 17 RIT2   Reconstituted Complex Homo sapiens 18 DHX40   Proximity Label-MS Homo sapiens 19 HIST1H2BG 8339 Proximity Label-MS Homo sapiens 20 ALB 213 Affinity Capture-MS Homo sapiens 21 MYB   Proximity Label-MS Homo sapiens 22 CTTN 2017 Cross-Linking-MS (XL-MS) Homo sapiens 23 PRPF40A 55660 Two-hybrid Homo sapiens 24 SOX2   Proximity Label-MS Homo sapiens 25 CNKSR2 22866 Affinity Capture-Western Homo sapiens 26 CENPA   Proximity Label-MS Homo sapiens 27 NFIX 4784 Proximity Label-MS Homo sapiens 28 APEX1 328 Proximity Label-MS Homo sapiens 29 CBX3 11335 Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 30 GCH1   Two-hybrid Homo sapiens 31 KLF8   Proximity Label-MS Homo sapiens 32 PAX6   Proximity Label-MS Homo sapiens 33 TRIM11   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 34 NFIC 4782 Proximity Label-MS Homo sapiens 35 POLR1E   Proximity Label-MS Homo sapiens 36 SSRP1 6749 Affinity Capture-MS Homo sapiens 37 CCT8L2   Affinity Capture-MS Homo sapiens 38 TEAD1   Proximity Label-MS Homo sapiens 39 CEBPA   Proximity Label-MS Homo sapiens 40 VSX1   Proximity Label-MS Homo sapiens View the network

Pathways in which RLF is involved

No pathways found