Gene description for GSDMA
Gene name gasdermin A
Gene symbol GSDMA
Other names/aliases FKSG9
GSDM
GSDM1
Species Homo sapiens
 Database cross references - GSDMA
ExoCarta ExoCarta_284110
Vesiclepedia VP_284110
Entrez Gene 284110
HGNC 13311
MIM 611218
UniProt Q96QA5  
 GSDMA identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for GSDMA
Molecular Function
    phosphatidylserine binding GO:0001786 IBA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA
    wide pore channel activity GO:0022829 IDA
    phosphatidylinositol-4-phosphate binding GO:0070273 IBA
Biological Process
    programmed cell death GO:0012501 IEA
    defense response to bacterium GO:0042742 IBA
    defense response to bacterium GO:0042742 IDA
    transmembrane transport GO:0055085 IEA
    pyroptotic inflammatory response GO:0070269 IBA
    pyroptotic inflammatory response GO:0070269 IDA
Subcellular Localization
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified GSDMA in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GSDMA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS16 10279
Affinity Capture-MS Homo sapiens
2 TRIM21 6737
Affinity Capture-MS Homo sapiens
3 FOXH1  
Affinity Capture-MS Homo sapiens
4 IFNA4  
Affinity Capture-MS Homo sapiens
5 SARAF  
Affinity Capture-MS Homo sapiens
6 RBM42  
Affinity Capture-MS Homo sapiens
7 ST8SIA1  
Affinity Capture-MS Homo sapiens
8 ANXA2 302
Affinity Capture-MS Homo sapiens
9 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
10 CCNC  
Affinity Capture-MS Homo sapiens
11 C18orf21  
Affinity Capture-MS Homo sapiens
12 FANCD2  
Affinity Capture-MS Homo sapiens
13 NDUFS5 4725
Affinity Capture-MS Homo sapiens
14 AMTN  
Affinity Capture-MS Homo sapiens
15 PIGT 51604
Affinity Capture-MS Homo sapiens
16 AGPAT1 10554
Affinity Capture-MS Homo sapiens
17 GGCT 79017
Affinity Capture-MS Homo sapiens
18 NRSN1  
Affinity Capture-MS Homo sapiens
19 DDX19B 11269
Affinity Capture-MS Homo sapiens
20 SH2D3A  
Affinity Capture-MS Homo sapiens
21 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CDK15  
Affinity Capture-MS Homo sapiens
23 SFR1 119392
Affinity Capture-MS Homo sapiens
24 CD274 29126
Affinity Capture-MS Homo sapiens
25 CDSN 1041
Affinity Capture-MS Homo sapiens
26 CCR1  
Affinity Capture-MS Homo sapiens
27 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DSC1 1823
Affinity Capture-MS Homo sapiens
29 C1orf35  
Affinity Capture-MS Homo sapiens
30 VWA3B 200403
Affinity Capture-MS Homo sapiens
31 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ZC3HC1  
Affinity Capture-MS Homo sapiens
33 PARK2  
Affinity Capture-MS Homo sapiens
34 GSKIP  
Affinity Capture-MS Homo sapiens
35 CAPZB 832
Affinity Capture-MS Homo sapiens
36 FTH1 2495
Affinity Capture-MS Homo sapiens
37 ST7  
Affinity Capture-MS Homo sapiens
38 BPHL 670
Affinity Capture-MS Homo sapiens
39 MBNL1 4154
Affinity Capture-MS Homo sapiens
40 SUZ12  
Affinity Capture-MS Homo sapiens
41 SPRR2E  
Affinity Capture-MS Homo sapiens
42 KLHL11  
Affinity Capture-MS Homo sapiens
43 WRAP73 49856
Affinity Capture-MS Homo sapiens
44 RNF115  
Affinity Capture-MS Homo sapiens
45 APOC2 344
Two-hybrid Homo sapiens
46 APOC1  
Two-hybrid Homo sapiens
47 ERCC3  
Affinity Capture-MS Homo sapiens
48 HES4  
Affinity Capture-MS Homo sapiens
49 PTDSS1 9791
Affinity Capture-MS Homo sapiens
50 PCOLCE2 26577
Affinity Capture-MS Homo sapiens
51 NDST2  
Affinity Capture-MS Homo sapiens
52 TGM3 7053
Affinity Capture-MS Homo sapiens
53 FANCG 2189
Affinity Capture-MS Homo sapiens
54 TEFM  
Affinity Capture-MS Homo sapiens
55 CYLD  
Affinity Capture-MS Homo sapiens
56 MCM2 4171
Affinity Capture-MS Homo sapiens
57 TSPAN6 7105
Affinity Capture-MS Homo sapiens
58 PINK1  
Affinity Capture-MS Homo sapiens
59 GOT1 2805
Affinity Capture-MS Homo sapiens
60 THAP10  
Affinity Capture-MS Homo sapiens
61 SLX4  
Affinity Capture-MS Homo sapiens
62 SSUH2  
Affinity Capture-MS Homo sapiens
63 APOC4  
Two-hybrid Homo sapiens
64 NUDT3 11165
Affinity Capture-MS Homo sapiens
65 RHBDD1 84236
Affinity Capture-MS Homo sapiens
66 OR2A4 79541
Affinity Capture-MS Homo sapiens
67 MOGAT3  
Affinity Capture-MS Homo sapiens
68 HCN1  
Affinity Capture-MS Homo sapiens
69 APTX  
Affinity Capture-MS Homo sapiens
70 UPK1A 11045
Affinity Capture-MS Homo sapiens
71 GABPA 2551
Affinity Capture-MS Homo sapiens
72 DDX39B 7919
Affinity Capture-MS Homo sapiens
73 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
74 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
75 STX17 55014
Affinity Capture-MS Homo sapiens
76 RIPPLY3  
Affinity Capture-MS Homo sapiens
77 LUCAT1  
Affinity Capture-RNA Homo sapiens
78 CUL4A 8451
Affinity Capture-MS Homo sapiens
79 TRIM11  
Affinity Capture-MS Homo sapiens
80 APIP 51074
Affinity Capture-MS Homo sapiens
81 PHF11 51131
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GSDMA is involved
No pathways found





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