Gene description for ZFYVE1
Gene name zinc finger, FYVE domain containing 1
Gene symbol ZFYVE1
Other names/aliases DFCP1
PPP1R172
SR3
TAFF1
ZNFN2A1
Species Homo sapiens
 Database cross references - ZFYVE1
ExoCarta ExoCarta_53349
Vesiclepedia VP_53349
Entrez Gene 53349
HGNC 13180
MIM 605471
UniProt Q9HBF4  
 ZFYVE1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZFYVE1
Molecular Function
    protein binding GO:0005515 IPI
    1-phosphatidylinositol binding GO:0005545 IBA
    1-phosphatidylinositol binding GO:0005545 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IBA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
    zinc ion binding GO:0008270 NAS
    phosphatidylinositol-3-phosphate binding GO:0032266 IBA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IBA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
Biological Process
    cellular response to starvation GO:0009267 IDA
    macroautophagy GO:0016236 IDA
    positive regulation by host of viral genome replication GO:0044829 IDA
    lipid droplet formation GO:0140042 IBA
    lipid droplet formation GO:0140042 IMP
Subcellular Localization
    phagophore assembly site GO:0000407 IDA
    mitochondrion GO:0005739 IDA
    autophagosome GO:0005776 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi stack GO:0005795 IDA
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 IDA
    membrane GO:0016020 IDA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    extrinsic component of omegasome membrane GO:0097629 IDA
    omegasome GO:1990462 IDA
 Experiment description of studies that identified ZFYVE1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZFYVE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFV1 4723
Affinity Capture-MS Homo sapiens
2 GLRX5 51218
Affinity Capture-MS Homo sapiens
3 CYC1 1537
Affinity Capture-MS Homo sapiens
4 TRIP6 7205
Affinity Capture-MS Homo sapiens
5 RPS27A 6233
Affinity Capture-MS Homo sapiens
6 ALDH7A1 501
Affinity Capture-MS Homo sapiens
7 TRIM13  
Co-localization Homo sapiens
8 USP4 7375
Affinity Capture-MS Homo sapiens
9 ATG2B 55102
Affinity Capture-MS Homo sapiens
10 AIFM1 9131
Affinity Capture-MS Homo sapiens
11 KCTD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MRPS2 51116
Affinity Capture-MS Homo sapiens
13 XPO1 7514
Affinity Capture-MS Homo sapiens
14 MRPL35  
Affinity Capture-MS Homo sapiens
15 LONRF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SUCLG2 8801
Affinity Capture-MS Homo sapiens
17 EDC4 23644
Affinity Capture-MS Homo sapiens
18 ATP6V1G1 9550
Affinity Capture-MS Homo sapiens
19 ACAA2 10449
Affinity Capture-MS Homo sapiens
20 BST2 684
Affinity Capture-MS Homo sapiens
21 EDEM1  
Affinity Capture-MS Homo sapiens
22 SPC24 147841
Affinity Capture-MS Homo sapiens
23 CUL3 8452
Affinity Capture-MS Homo sapiens
24 CHD6 84181
Affinity Capture-MS Homo sapiens
25 CHCHD2P9  
Affinity Capture-MS Homo sapiens
26 MID1 4281
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SUCLA2 8803
Affinity Capture-MS Homo sapiens
28 MRPL49 740
Affinity Capture-MS Homo sapiens
29 APP 351
Reconstituted Complex Homo sapiens
30 HCCS 3052
Affinity Capture-MS Homo sapiens
31 UBB 7314
Affinity Capture-MS Homo sapiens
32 BCL2L1 598
Two-hybrid Homo sapiens
33 WDR45  
Affinity Capture-MS Homo sapiens
34 DNAJC3 5611
Affinity Capture-MS Homo sapiens
35 RDH13  
Affinity Capture-MS Homo sapiens
36 JMY  
Affinity Capture-MS Homo sapiens
37 UQCRC1 7384
Affinity Capture-MS Homo sapiens
38 LIMD1 8994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 OCIAD2 132299
Affinity Capture-MS Homo sapiens
40 MAGOHB 55110
Two-hybrid Homo sapiens
41 CLPB 81570
Affinity Capture-MS Homo sapiens
42 VDAC1 7416
Affinity Capture-MS Homo sapiens
43 IDH3G 3421
Affinity Capture-MS Homo sapiens
44 MRPL28 10573
Affinity Capture-MS Homo sapiens
45 POLRMT 5442
Affinity Capture-MS Homo sapiens
46 CUL4A 8451
Affinity Capture-MS Homo sapiens
47 ERAL1  
Affinity Capture-MS Homo sapiens
48 WHAMM  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZFYVE1 is involved
No pathways found





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