Gene description for GLRX5
Gene name glutaredoxin 5
Gene symbol GLRX5
Other names/aliases C14orf87
FLB4739
GRX5
PR01238
PRO1238
PRSA
Species Homo sapiens
 Database cross references - GLRX5
ExoCarta ExoCarta_51218
Vesiclepedia VP_51218
Entrez Gene 51218
HGNC 20134
MIM 609588
UniProt Q86SX6  
 GLRX5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GLRX5
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    2 iron, 2 sulfur cluster binding GO:0051537 IEA
Biological Process
    intracellular iron ion homeostasis GO:0006879 NAS
    iron-sulfur cluster assembly GO:0016226 NAS
    hemopoiesis GO:0030097 ISS
    [2Fe-2S] cluster assembly GO:0044571 IGI
    cell redox homeostasis GO:0045454 NAS
    protein maturation by [2Fe-2S] cluster transfer GO:0106034 IGI
    protein maturation by [4Fe-4S] cluster transfer GO:0106035 IGI
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISS
    mitochondrion GO:0005739 NAS
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    iron-sulfur cluster assembly complex GO:1990229 IPI
 Experiment description of studies that identified GLRX5 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GLRX5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPST 4357
Co-fractionation Homo sapiens
2 GSTP1 2950
Co-fractionation Homo sapiens
3 ETHE1 23474
Co-fractionation Homo sapiens
4 CISD3 284106
Affinity Capture-MS Homo sapiens
5 RIT1 6016
Negative Genetic Homo sapiens
6 C1orf198 84886
Co-fractionation Homo sapiens
7 PRDX5 25824
Co-fractionation Homo sapiens
8 C15orf48  
Affinity Capture-MS Homo sapiens
9 PRDX6 9588
Co-fractionation Homo sapiens
10 PSAP 5660
Co-fractionation Homo sapiens
11 GLOD4 51031
Co-fractionation Homo sapiens
12 GUK1 2987
Co-fractionation Homo sapiens
13 AK2 204
Co-fractionation Homo sapiens
14 AK4 205
Co-fractionation Homo sapiens
15 ALDH4A1 8659
Co-fractionation Homo sapiens
16 C6orf57  
Affinity Capture-MS Homo sapiens
17 MTPN 136319
Co-fractionation Homo sapiens
18 FXN  
Co-fractionation Homo sapiens
19 BOLA3  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
20 CLPP 8192
Proximity Label-MS Homo sapiens
21 PFN1 5216
Cross-Linking-MS (XL-MS) Homo sapiens
22 NME4 4833
Affinity Capture-MS Homo sapiens
23 LAP3 51056
Co-fractionation Homo sapiens
24 GRHPR 9380
Co-fractionation Homo sapiens
25 TCOF1 6949
Co-fractionation Homo sapiens
26 KEAP1 9817
Two-hybrid Homo sapiens
27 PAICS 10606
Co-fractionation Homo sapiens
28 ATP5A1 498
Affinity Capture-MS Homo sapiens
29 GABARAPL2 11345
Co-fractionation Homo sapiens
30 DGUOK  
Co-fractionation Homo sapiens
31 COQ7  
Affinity Capture-MS Homo sapiens
32 ARF1 375
Co-fractionation Homo sapiens
33 ELAC2 60528
Co-fractionation Homo sapiens
34 TXNDC12 51060
Co-fractionation Homo sapiens
35 BOLA1 51027
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
36 PARK7 11315
Co-fractionation Homo sapiens
37 SPATA20  
Affinity Capture-MS Homo sapiens
38 APP 351
Reconstituted Complex Homo sapiens
39 HADH 3033
Co-fractionation Homo sapiens
40 TXN 7295
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
41 IDH2 3418
Co-fractionation Homo sapiens
42 ISCA2 122961
Co-fractionation Homo sapiens
43 NDUFS3 4722
Affinity Capture-MS Homo sapiens
44 CRYZ 1429
Co-fractionation Homo sapiens
45 AIFM1 9131
Co-fractionation Homo sapiens
46 MSRB3 253827
Co-fractionation Homo sapiens
47 PMPCA 23203
Co-fractionation Homo sapiens
48 COQ9  
Affinity Capture-MS Homo sapiens
49 SPR 6697
Co-fractionation Homo sapiens
50 LACTB2 51110
Co-fractionation Homo sapiens
51 CHCHD2  
Affinity Capture-MS Homo sapiens
52 DHRS4 10901
Affinity Capture-MS Homo sapiens
53 HINT2 84681
Co-fractionation Homo sapiens
54 PPA2 27068
Co-fractionation Homo sapiens
55 ENO1 2023
Co-fractionation Homo sapiens
56 CHCHD10  
Affinity Capture-MS Homo sapiens
57 CTSB 1508
Co-fractionation Homo sapiens
58 ZFYVE1 53349
Affinity Capture-MS Homo sapiens
59 TBCA 6902
Co-fractionation Homo sapiens
60 RAB11FIP5 26056
Co-fractionation Homo sapiens
61 C21orf33  
Co-fractionation Homo sapiens
62 ACO2 50
Co-fractionation Homo sapiens
63 PRDX2 7001
Co-fractionation Homo sapiens
64 HINT1 3094
Co-fractionation Homo sapiens
65 CLIC4 25932
Co-fractionation Homo sapiens
66 KRAS 3845
Negative Genetic Homo sapiens
67 ACN9  
Affinity Capture-MS Homo sapiens
68 SRI 6717
Co-fractionation Homo sapiens
69 CMPK1 51727
Co-fractionation Homo sapiens
70 TLN1 7094
Cross-Linking-MS (XL-MS) Homo sapiens
71 COX4I1 1327
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which GLRX5 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Mitochondrial iron-sulfur cluster biogenesis TAS Reactome





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