Gene description for OCIAD2
Gene name OCIA domain containing 2
Gene symbol OCIAD2
Other names/aliases -
Species Homo sapiens
 Database cross references - OCIAD2
ExoCarta ExoCarta_132299
Vesiclepedia VP_132299
Entrez Gene 132299
HGNC 28685
UniProt Q56VL3  
 OCIAD2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for OCIAD2
Biological Process
    endocytosis GO:0006897 ISS
    response to bacterium GO:0009617 IEA
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 ISS
    hematopoietic stem cell homeostasis GO:0061484 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    lysosome GO:0005764 ISS
    endosome GO:0005768 ISS
    Golgi apparatus GO:0005794 ISS
 Experiment description of studies that identified OCIAD2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OCIAD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOMM40 10452
Co-fractionation Homo sapiens
2 C15orf48  
Co-fractionation Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 NAAA  
Affinity Capture-MS Homo sapiens
5 GPR45  
Affinity Capture-MS Homo sapiens
6 HADHA 3030
Co-fractionation Homo sapiens
7 ILF3 3609
Co-fractionation Homo sapiens
8 SLC25A3 5250
Co-fractionation Homo sapiens
9 ICAM1 3383
Co-fractionation Homo sapiens
10 ACOT9 23597
Co-fractionation Homo sapiens
11 APOO 79135
Proximity Label-MS Homo sapiens
12 E2F4  
Affinity Capture-MS Homo sapiens
13 TSPAN15 23555
Affinity Capture-MS Homo sapiens
14 RMND1 55005
Proximity Label-MS Homo sapiens
15 SFXN1 94081
Proximity Label-MS Homo sapiens
16 RAB1A 5861
Co-fractionation Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 MMGT1 93380
Co-fractionation Homo sapiens
19 ATP5L 10632
Co-fractionation Homo sapiens
20 ATP5J2 9551
Co-fractionation Homo sapiens
21 MGST1 4257
Co-fractionation Homo sapiens
22 SLC25A20 788
Co-fractionation Homo sapiens
23 USMG5 84833
Co-fractionation Homo sapiens
24 RPA3 6119
Proximity Label-MS Homo sapiens
25 TOMM5  
Co-fractionation Homo sapiens
26 MCM2 4171
Affinity Capture-MS Homo sapiens
27 RAB7A 7879
Co-fractionation Homo sapiens
28 SLC25A51  
Proximity Label-MS Homo sapiens
29 RAB11A 8766
Co-fractionation Homo sapiens
30 CYB5R1 51706
Co-fractionation Homo sapiens
31 CYB5R3 1727
Co-fractionation Homo sapiens
32 ACTB 60
Co-fractionation Homo sapiens
33 RNF2  
Affinity Capture-MS Homo sapiens
34 VDAC1 7416
Co-fractionation Homo sapiens
35 VDAC3 7419
Co-fractionation Homo sapiens
36 DNAJC30  
Proximity Label-MS Homo sapiens
37 GNG5 2787
Co-fractionation Homo sapiens
38 VDAC2 7417
Co-fractionation Homo sapiens
39 AKAP1 8165
Proximity Label-MS Homo sapiens
40 MGST3 4259
Co-fractionation Homo sapiens
41 SCCPDH 51097
Co-fractionation Homo sapiens
42 ZFYVE1 53349
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which OCIAD2 is involved
No pathways found





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