Gene description for CA14
Gene name carbonic anhydrase XIV
Gene symbol CA14
Other names/aliases CAXiV
Species Homo sapiens
 Database cross references - CA14
ExoCarta ExoCarta_23632
Vesiclepedia VP_23632
Entrez Gene 23632
HGNC 1372
MIM 604832
UniProt Q9ULX7  
 CA14 identified in sEVs derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
 Gene ontology annotations for CA14
Molecular Function
    carbonate dehydratase activity GO:0004089 IBA
    zinc ion binding GO:0008270 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    basolateral plasma membrane GO:0016323 IEA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified CA14 in sEVs
1
Experiment ID 254
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 257
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 258
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 260
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CA14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MR1  
Affinity Capture-MS Homo sapiens
3 SLC7A1 6541
Affinity Capture-MS Homo sapiens
4 RAB35 11021
Affinity Capture-MS Homo sapiens
5 COG8 84342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PLAA 9373
Affinity Capture-MS Homo sapiens
7 GALE 2582
Affinity Capture-MS Homo sapiens
8 EXOC7 23265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KNTC1 9735
Affinity Capture-MS Homo sapiens
10 ORC4  
Affinity Capture-MS Homo sapiens
11 RAB13 5872
Affinity Capture-MS Homo sapiens
12 FANCD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EXOC5 10640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KIF14 9928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EXOC8 149371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ZNF273  
Two-hybrid Homo sapiens
17 HLA-F 3134
Affinity Capture-MS Homo sapiens
18 TNPO3 23534
Affinity Capture-MS Homo sapiens
19 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 THADA 63892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 EMC7 56851
Affinity Capture-MS Homo sapiens
22 IQCB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 WDR54  
Affinity Capture-MS Homo sapiens
24 IMMP2L 83943
Affinity Capture-MS Homo sapiens
25 RRP1 8568
Affinity Capture-MS Homo sapiens
26 AP1M1 8907
Affinity Capture-MS Homo sapiens
27 COG7 91949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DCPS 28960
Affinity Capture-MS Homo sapiens
29 EVA1B 55194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 COG2 22796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 KIAA1524 57650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 EIF2B3 8891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 LTN1 26046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GHITM 27069
Affinity Capture-MS Homo sapiens
35 SLC38A7 55238
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 EIF2B5 8893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PI4KA 5297
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 NUP160 23279
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 XPO6 23214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NCAPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 NF1 4763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SAAL1 113174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 XPO4 64328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TBRG4 9238
Affinity Capture-MS Homo sapiens
45 TNPO2 30000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DNM1L 10059
Affinity Capture-MS Homo sapiens
47 MON2 23041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 EXOC1 55763
Affinity Capture-MS Homo sapiens
49 CLSTN3 9746
Affinity Capture-MS Homo sapiens
50 MTOR 2475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MAGT1 84061
Affinity Capture-MS Homo sapiens
52 EXOC6 54536
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 EIF2B2 8892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SLC39A3  
Affinity Capture-MS Homo sapiens
55 DNAJC16  
Affinity Capture-MS Homo sapiens
56 EXOC6B 23233
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 GNA13 10672
Affinity Capture-MS Homo sapiens
58 SRC 6714
Affinity Capture-MS Homo sapiens
59 EIF2B1 1967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 NUP85 79902
Affinity Capture-MS Homo sapiens
61 HEATR1 55127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RABIF  
Affinity Capture-MS Homo sapiens
63 RANBP6 26953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ATP2A3 489
Affinity Capture-MS Homo sapiens
65 COG4 25839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 EIF2B4 8890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TNPO1 3842
Affinity Capture-MS Homo sapiens
68 SLC22A18 5002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 ERMP1 79956
Affinity Capture-MS Homo sapiens
70 PON2 5445
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CA14 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Reversible hydration of carbon dioxide TAS Reactome





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