Gene description for Itgb1
Gene name integrin beta 1 (fibronectin receptor beta)
Gene symbol Itgb1
Other names/aliases 4633401G24Rik
AA409975
AA960159
CD29
ENSMUSG00000051907
Fnrb
Gm9863
gpIIa
Species Mus musculus
 Database cross references - Itgb1
ExoCarta ExoCarta_16412
Vesiclepedia VP_16412
Entrez Gene 16412
UniProt P09055  
 Itgb1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Embryonic fibroblasts 18494037    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 36648227    
Macrophages 36648227    
Macrophages 36648227    
Mast cells 17486113    
Mov neuroglial cells 15210972    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Itgb1
Molecular Function
    magnesium ion binding GO:0000287 IEA
    magnesium ion binding GO:0000287 ISO
    fibronectin binding GO:0001968 IBA
    fibronectin binding GO:0001968 IEA
    fibronectin binding GO:0001968 ISO
    protease binding GO:0002020 IEA
    protease binding GO:0002020 ISO
    actin binding GO:0003779 IEA
    actin binding GO:0003779 ISO
    signaling receptor binding GO:0005102 ISO
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IPI
    integrin binding GO:0005178 ISO
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 ISO
    kinase binding GO:0019900 ISO
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 ISO
    protein domain specific binding GO:0019904 ISO
    C-X3-C chemokine binding GO:0019960 IBA
    C-X3-C chemokine binding GO:0019960 ISO
    C-X3-C chemokine binding GO:0019960 ISS
    signaling receptor activity GO:0038023 IDA
    laminin binding GO:0043236 IBA
    laminin binding GO:0043236 IDA
    laminin binding GO:0043236 ISO
    protein-containing complex binding GO:0044877 ISO
    protein heterodimerization activity GO:0046982 ISO
    protein heterodimerization activity GO:0046982 ISS
    cell adhesion molecule binding GO:0050839 ISO
    alpha-actinin binding GO:0051393 ISO
    collagen binding involved in cell-matrix adhesion GO:0098639 IBA
    collagen binding involved in cell-matrix adhesion GO:0098639 IEA
    collagen binding involved in cell-matrix adhesion GO:0098639 ISO
    integrin binding involved in cell-matrix adhesion GO:0098640 IDA
    protein tyrosine kinase binding GO:1990782 IEA
    protein tyrosine kinase binding GO:1990782 ISO
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    establishment of mitotic spindle orientation GO:0000132 IEA
    establishment of mitotic spindle orientation GO:0000132 ISO
    in utero embryonic development GO:0001701 IMP
    tissue homeostasis GO:0001894 ISO
    cell migration involved in sprouting angiogenesis GO:0002042 IMP
    positive regulation of neuroblast proliferation GO:0002052 IMP
    phagocytosis GO:0006909 ISO
    cell adhesion GO:0007155 ISO
    leukocyte cell-cell adhesion GO:0007159 ISO
    leukocyte cell-cell adhesion GO:0007159 NAS
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IGI
    cell-matrix adhesion GO:0007160 IMP
    cell-matrix adhesion GO:0007160 ISO
    cell-matrix adhesion GO:0007160 NAS
    calcium-independent cell-matrix adhesion GO:0007161 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    integrin-mediated signaling pathway GO:0007229 IBA
    integrin-mediated signaling pathway GO:0007229 ISO
    integrin-mediated signaling pathway GO:0007229 NAS
    neuroblast proliferation GO:0007405 IMP
    muscle organ development GO:0007517 IEA
    myoblast fusion GO:0007520 ISS
    regulation of G protein-coupled receptor signaling pathway GO:0008277 ISO
    cell population proliferation GO:0008283 IMP
    negative regulation of cell population proliferation GO:0008285 ISO
    germ cell migration GO:0008354 IMP
    visual learning GO:0008542 IGI
    visual learning GO:0008542 IMP
    regulation of collagen catabolic process GO:0010710 ISO
    regulation of collagen catabolic process GO:0010710 ISS
    positive regulation of fibroblast migration GO:0010763 IEA
    positive regulation of fibroblast migration GO:0010763 ISO
    positive regulation of cell-substrate adhesion GO:0010811 ISO
    positive regulation of neuron projection development GO:0010976 ISO
    response to muscle activity GO:0014850 IDA
    cell migration GO:0016477 IBA
    formation of radial glial scaffolds GO:0021943 IMP
    CD40 signaling pathway GO:0023035 IEA
    CD40 signaling pathway GO:0023035 ISO
    cell projection organization GO:0030030 ISO
    lamellipodium assembly GO:0030032 ISO
    neuron differentiation GO:0030182 IMP
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of cell migration GO:0030335 ISS
    neuron projection development GO:0031175 IMP
    negative regulation of cell projection organization GO:0031345 ISO
    cell-substrate adhesion GO:0031589 ISO
    receptor internalization GO:0031623 IDA
    protein transport within lipid bilayer GO:0032594 ISO
    cell adhesion mediated by integrin GO:0033627 IBA
    cell adhesion mediated by integrin GO:0033627 ISO
    cell adhesion mediated by integrin GO:0033627 ISS
    cell-cell adhesion mediated by integrin GO:0033631 IEA
    heterotypic cell-cell adhesion GO:0034113 IEA
    heterotypic cell-cell adhesion GO:0034113 ISO
    negative regulation of Rho protein signal transduction GO:0035024 IGI
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    stress fiber assembly GO:0043149 IMP
    positive regulation of GTPase activity GO:0043547 ISO
    sarcomere organization GO:0045214 IMP
    myoblast differentiation GO:0045445 ISS
    negative regulation of neuron differentiation GO:0045665 IMP
    negative regulation of neuron differentiation GO:0045665 ISO
    positive regulation of neuron differentiation GO:0045666 ISO
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IEA
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 ISO
    positive regulation of angiogenesis GO:0045766 IEA
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of endocytosis GO:0045807 ISO
    negative regulation of vasoconstriction GO:0045906 ISO
    negative regulation of vasoconstriction GO:0045906 ISS
    mesodermal cell differentiation GO:0048333 IEA
    myoblast fate specification GO:0048626 IMP
    axon extension GO:0048675 IGI
    axon extension GO:0048675 IMP
    dendrite morphogenesis GO:0048813 IGI
    dendrite morphogenesis GO:0048813 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    modulation of chemical synaptic transmission GO:0050804 IDA
    modulation of chemical synaptic transmission GO:0050804 IMP
    leukocyte tethering or rolling GO:0050901 IEA
    leukocyte tethering or rolling GO:0050901 ISO
    regulation of cell cycle GO:0051726 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    positive regulation of glutamate uptake involved in transmission of nerve impulse GO:0051951 IMP
    cardiac muscle cell differentiation GO:0055007 IMP
    cardiac muscle cell myoblast differentiation GO:0060379 IMP
    cardiac cell fate specification GO:0060912 IMP
    bicellular tight junction assembly GO:0070830 ISO
    cellular response to low-density lipoprotein particle stimulus GO:0071404 IDA
    basement membrane organization GO:0071711 IMP
    positive regulation of wound healing GO:0090303 IEA
    positive regulation of wound healing GO:0090303 ISO
    cell-cell adhesion GO:0098609 IBA
    maintenance of postsynaptic specialization structure GO:0098880 ISO
    regulation of spontaneous synaptic transmission GO:0150003 IMP
    regulation of postsynaptic neurotransmitter receptor diffusion trapping GO:0150054 ISO
    reactive gliosis GO:0150103 IMP
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 IEA
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 ISO
    regulation of inward rectifier potassium channel activity GO:1901979 IMP
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 ISS
    regulation of synapse pruning GO:1905806 IDA
    regulation of synapse pruning GO:1905806 IMP
    negative regulation of anoikis GO:2000811 IEA
    negative regulation of anoikis GO:2000811 ISO
Subcellular Localization
    acrosomal vesicle GO:0001669 ISO
    basement membrane GO:0005604 ISO
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 ISO
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISS
    integrin complex GO:0008305 IBA
    integrin complex GO:0008305 ISO
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    intercalated disc GO:0014704 IDA
    membrane GO:0016020 IDA
    lamellipodium GO:0030027 IEA
    hemidesmosome GO:0030056 ISO
    filopodium GO:0030175 IEA
    filopodium GO:0030175 ISO
    cytoplasmic vesicle GO:0031410 IDA
    neuromuscular junction GO:0031594 IDA
    neuromuscular junction GO:0031594 ISO
    ruffle membrane GO:0032587 IEA
    ruffle membrane GO:0032587 ISO
    integrin alpha1-beta1 complex GO:0034665 IEA
    integrin alpha1-beta1 complex GO:0034665 ISO
    integrin alpha2-beta1 complex GO:0034666 IEA
    integrin alpha2-beta1 complex GO:0034666 ISO
    integrin alpha3-beta1 complex GO:0034667 IEA
    integrin alpha3-beta1 complex GO:0034667 ISO
    integrin alpha4-beta1 complex GO:0034668 ISO
    integrin alpha5-beta1 complex GO:0034674 IEA
    integrin alpha5-beta1 complex GO:0034674 ISO
    integrin alpha6-beta1 complex GO:0034675 IEA
    integrin alpha6-beta1 complex GO:0034675 ISO
    integrin alpha7-beta1 complex GO:0034677 IDA
    integrin alpha7-beta1 complex GO:0034677 IPI
    integrin alpha9-beta1 complex GO:0034679 IDA
    integrin alpha9-beta1 complex GO:0034679 ISO
    integrin alpha10-beta1 complex GO:0034680 IEA
    integrin alpha10-beta1 complex GO:0034680 ISO
    integrin alpha11-beta1 complex GO:0034681 IEA
    integrin alpha11-beta1 complex GO:0034681 ISO
    integrin alphav-beta1 complex GO:0034682 IEA
    integrin alphav-beta1 complex GO:0034682 ISO
    myelin sheath abaxonal region GO:0035748 IDA
    sarcolemma GO:0042383 IDA
    sarcolemma GO:0042383 ISO
    melanosome GO:0042470 IEA
    dendritic spine GO:0043197 IDA
    dendritic spine GO:0043197 ISO
    receptor complex GO:0043235 ISO
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 ISO
    postsynaptic membrane GO:0045211 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    recycling endosome GO:0055037 IEA
    synaptic membrane GO:0097060 IDA
    synaptic membrane GO:0097060 IDA
    glial cell projection GO:0097386 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    glycinergic synapse GO:0098690 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 ISO
    cerebellar climbing fiber to Purkinje cell synapse GO:0150053 IDA
    cerebellar climbing fiber to Purkinje cell synapse GO:0150053 IMP
 Experiment description of studies that identified Itgb1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 73
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors "Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ"
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
3
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 569
MISEV standards
✘ Biophysical techniques
✔
Hsp90|Gapdh
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36648227    
Organism Mus musculus
Experiment description Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes
Authors "Imamiya R, Shinohara A, Yakura D, Yamaguchi T, Ueda K, Oguro A, Minamiyama Y, Ichikawa H, Horiguchi Y, Osada-Oka M."
Journal name mBio
Publication year 2023
Sample Macrophages
Sample name RAW264.2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
7
Experiment ID 570
MISEV standards
✘ Biophysical techniques
✔
Hsp90|Gapdh|Cd9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36648227    
Organism Mus musculus
Experiment description Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes
Authors "Imamiya R, Shinohara A, Yakura D, Yamaguchi T, Ueda K, Oguro A, Minamiyama Y, Ichikawa H, Horiguchi Y, Osada-Oka M."
Journal name mBio
Publication year 2023
Sample Macrophages
Sample name RAW264.2 - E. coli infected
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
8
Experiment ID 571
MISEV standards
✘ Biophysical techniques
✔
Hsp90|Gapdh|Cd9|Cd63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36648227    
Organism Mus musculus
Experiment description Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes
Authors "Imamiya R, Shinohara A, Yakura D, Yamaguchi T, Ueda K, Oguro A, Minamiyama Y, Ichikawa H, Horiguchi Y, Osada-Oka M."
Journal name mBio
Publication year 2023
Sample Macrophages
Sample name RAW264.2 - E. coli infected
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
9
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
10
Experiment ID 39
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|HSC70|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors "Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G"
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
11
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Itgb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Affinity Capture-MS Homo sapiens
2 Ptpn2  
Co-fractionation Mus musculus
3 FZD6 8323
Affinity Capture-MS Homo sapiens
4 ITGA5 3678
Affinity Capture-MS Homo sapiens
5 SSR3 6747
Affinity Capture-MS Homo sapiens
6 CACNA2D1 781
Affinity Capture-MS Homo sapiens
7 Igfbp2 16008
Co-fractionation Mus musculus
8 CANX 821
Affinity Capture-MS Homo sapiens
9 ATP5I 521
Affinity Capture-MS Homo sapiens
10 SRPRB 58477
Affinity Capture-MS Homo sapiens
11 ITGA1 3672
Affinity Capture-MS Homo sapiens
12 ATP2B1 490
Affinity Capture-MS Homo sapiens
13 SLC25A1 6576
Affinity Capture-MS Homo sapiens
14 ITGA3 3675
Affinity Capture-MS Homo sapiens
15 Cdh17  
Co-fractionation Mus musculus
16 Itga6 16403
Affinity Capture-Western Mus musculus
17 SLC1A5 6510
Affinity Capture-MS Homo sapiens
18 SF1 7536
Affinity Capture-MS Homo sapiens
19 PDIA3 2923
Affinity Capture-MS Homo sapiens
20 UBAC2 337867
Affinity Capture-MS Homo sapiens
21 ITGA6 3655
Affinity Capture-MS Homo sapiens
22 Fermt2  
FRET Mus musculus
Reconstituted Complex Mus musculus
23 FAT1 2195
Affinity Capture-MS Homo sapiens
24 HSP90B1 7184
Affinity Capture-MS Homo sapiens
25 ITGA2 3673
Affinity Capture-MS Homo sapiens
26 Tmem173  
Proximity Label-MS Mus musculus
27 ITGAV 3685
Affinity Capture-MS Homo sapiens
28 CHPT1  
Affinity Capture-MS Homo sapiens
29 Tln1 21894
FRET Mus musculus
30 Itga3 16400
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
31 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
32 Traf6  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
33 USMG5 84833
Affinity Capture-MS Homo sapiens
34 Unk  
Affinity Capture-RNA Mus musculus
35 FAM111B 374393
Affinity Capture-MS Homo sapiens
36 MTOR 2475
Affinity Capture-MS Homo sapiens
37 IGF2R 3482
Affinity Capture-MS Homo sapiens
38 TIMM23 100287932
Affinity Capture-MS Homo sapiens
39 RPRD1B 58490
Affinity Capture-MS Homo sapiens
40 DDX42 11325
Affinity Capture-MS Homo sapiens
41 HYOU1 10525
Affinity Capture-MS Homo sapiens
42 CLPTM1L 81037
Affinity Capture-MS Homo sapiens
43 Sstr3  
Proximity Label-MS Mus musculus
44 COLGALT1 79709
Affinity Capture-MS Homo sapiens
45 GALNT2 2590
Affinity Capture-MS Homo sapiens
46 REPS2  
Affinity Capture-MS Homo sapiens
47 ARHGEF12 23365
Affinity Capture-MS Homo sapiens
48 RBCK1  
Affinity Capture-MS Homo sapiens
49 Vegfb  
Co-fractionation Mus musculus
50 ATP5O 539
Affinity Capture-MS Homo sapiens
51 Itga1  
Co-fractionation Mus musculus
52 SLC25A5 292
Affinity Capture-MS Homo sapiens
53 RBM10  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Itgb1 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Axon guidance IEA Reactome
Basigin interactions IEA Reactome
Cell junction organization IEA Reactome
Cell surface interactions at the vascular wall IEA Reactome
Cell-Cell communication IEA Reactome
Cell-extracellular matrix interactions IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Developmental Biology IEA Reactome
ECM proteoglycans IEA Reactome
Elastic fibre formation IEA Reactome
Extracellular matrix organization IEA Reactome
Fibronectin matrix formation IEA Reactome
G alpha (s) signalling events IEA Reactome
GPCR downstream signalling IEA Reactome
GPER1 signaling IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IEA Reactome
Integrin cell surface interactions IEA Reactome
L1CAM interactions IEA Reactome
Laminin interactions IEA Reactome
Localization of the PINCH-ILK-PARVIN complex to focal adhesions IEA Reactome
MET activates PTK2 signaling IEA Reactome
MET interacts with TNS proteins IEA Reactome
MET promotes cell motility IEA Reactome
Molecules associated with elastic fibres IEA Reactome
Nervous system development IEA Reactome
Non-integrin membrane-ECM interactions IEA Reactome
RAC1 GTPase cycle IEA Reactome
RAC2 GTPase cycle IEA Reactome
RAC3 GTPase cycle IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
RHO GTPase cycle IEA Reactome
RHOG GTPase cycle IEA Reactome
Signal Transduction IEA Reactome
Signal transduction by L1 IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by MET IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGFB family members IEA Reactome
Syndecan interactions IEA Reactome
TGF-beta receptor signaling activates SMADs IEA Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells IEA Reactome





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