ExoCarta: Gene summary

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Gene description for OS9
Gene name	osteosarcoma amplified 9, endoplasmic reticulum lectin
Gene symbol	OS9
Other names/aliases	ERLEC2 OS-9
Species	Homo sapiens
Database cross references - OS9
ExoCarta	ExoCarta_10956
Vesiclepedia	VP_10956
Entrez Gene	10956
HGNC	16994
MIM	609677
UniProt	Q13438
OS9 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565
Saliva	19199708

Gene ontology annotations for OS9

Molecular Function
	protease binding	GO:0002020	IEA
	protein binding	GO:0005515	IDA
	protein binding	GO:0005515	IPI
	carbohydrate binding	GO:0030246	IEA
Biological Process
	ubiquitin-dependent protein catabolic process	GO:0006511	IMP
	protein targeting	GO:0006605	IEA
	protein retention in ER lumen	GO:0006621	IDA
	protein ubiquitination	GO:0016567	IMP
	endoplasmic reticulum unfolded protein response	GO:0030968	IEA
	retrograde protein transport, ER to cytosol	GO:0030970	IBA
	response to endoplasmic reticulum stress	GO:0034976	IDA
	ERAD pathway	GO:0036503	IMP
	negative regulation of retrograde protein transport, ER to cytosol	GO:1904153	IMP
Subcellular Localization
	Hrd1p ubiquitin ligase complex	GO:0000836	NAS
	endoplasmic reticulum	GO:0005783	IDA
	endoplasmic reticulum lumen	GO:0005788	IBA
	endoplasmic reticulum lumen	GO:0005788	IDA
	endoplasmic reticulum membrane	GO:0005789	TAS

Experiment description of studies that identified OS9 in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

834

MISEV standards
✔ EM	Biophysical techniques
✔ LAMP2\|CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

835

MISEV standards
✔ EM	Biophysical techniques
✔ CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

MISEV standards
✔ IEM	Biophysical techniques
✔ TSG101\|Alix\|CD63\|CD81	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

19199708

Organism

Homo sapiens

Experiment description

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

Authors

"Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"

Journal name

JPR

Publication year

2009

Sample

Saliva

Sample name

Saliva

Isolation/purification methods

Differential centrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy

Protein-protein interactions for OS9

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

COL6A1

1291

Affinity Capture-MS

Homo sapiens

UGGT2

55757

Affinity Capture-MS

Homo sapiens

CNTNAP3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DERL2

51009

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

COL18A1

80781

Affinity Capture-MS

Homo sapiens

CD48

962

Affinity Capture-MS

Homo sapiens

LCN6

Affinity Capture-MS

Homo sapiens

KLK5

25818

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

XRCC1

7515

Affinity Capture-MS

Homo sapiens

WNT7A

Affinity Capture-MS

Homo sapiens

DEFB121

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GXYLT2

Affinity Capture-MS

Homo sapiens

PLD4

Affinity Capture-MS

Homo sapiens

DNAJC25

548645

Proximity Label-MS

Homo sapiens

TMEM5

Affinity Capture-MS

Homo sapiens

IL22RA2

Affinity Capture-MS

Homo sapiens

SYVN1

84447

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

FAM8A1

51439

Affinity Capture-MS

Homo sapiens

SNRPD2

6633

Two-hybrid

Homo sapiens

COCH

1690

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

Slc12a3

Affinity Capture-Western

Mus musculus

LONP2

83752

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GABRA1

Affinity Capture-Western

Homo sapiens

GXYLT1

283464

Affinity Capture-MS

Homo sapiens

SULF2

55959

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VKORC1

79001

Affinity Capture-MS

Homo sapiens

FBXO15

201456

Affinity Capture-MS

Homo sapiens

SEL1L

6400

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

CLEC2B

Affinity Capture-MS

Homo sapiens

MRPL12

6182

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZNF512B

Two-hybrid

Homo sapiens

NUP210

23225

Affinity Capture-MS

Homo sapiens

UGT1A10

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLAMF1

6504

Affinity Capture-MS

Homo sapiens

NXPH3

Affinity Capture-MS

Homo sapiens

NXPH1

Affinity Capture-MS

Homo sapiens

Ncstn

59287

Affinity Capture-MS

Mus musculus

SEPN1

57190

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GAL3ST2

Affinity Capture-MS

Homo sapiens

SERPINH1

871

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NOS1

Affinity Capture-MS

Homo sapiens

TMTC4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SMPD1

6609

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PLXNA2

5362

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SERPINA1

5265

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

IL17RA

23765

Affinity Capture-MS

Homo sapiens

TMEM201

199953

Affinity Capture-MS

Homo sapiens

SULF1

23213

Affinity Capture-MS

Homo sapiens

ISLR

3671

Affinity Capture-MS

Homo sapiens

FAF2

23197

Affinity Capture-MS

Homo sapiens

SORL1

6653

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

P3H4

10609

Affinity Capture-MS

Homo sapiens

TRPV4

59341

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

PRELP

5549

Affinity Capture-MS

Homo sapiens

LIFR

3977

Affinity Capture-MS

Homo sapiens

TAZ

Affinity Capture-MS

Homo sapiens

TSHR

7253

Affinity Capture-MS

Homo sapiens

LRRC59

55379

Proximity Label-MS

Homo sapiens

MYH9

4627

Affinity Capture-MS

Homo sapiens

BSG

682

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

DPEP2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PPIB

5479

Affinity Capture-MS

Homo sapiens

ATP1B4

Affinity Capture-MS

Homo sapiens

SERPINI1

Affinity Capture-Western

Homo sapiens

FUT8

2530

Affinity Capture-MS

Homo sapiens

RBX1

9978

Two-hybrid

Homo sapiens

NTN1

9423

Affinity Capture-MS

Homo sapiens

AMFR

267

Affinity Capture-Western

Homo sapiens

HSP90B1

7184

FRET		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

EGLN1

54583

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

PLOD2

5352

Affinity Capture-MS

Homo sapiens

C12orf49

Affinity Capture-MS

Homo sapiens

ACVR1B

Two-hybrid

Homo sapiens

IDS

Affinity Capture-MS

Homo sapiens

VWA1

64856

Affinity Capture-MS

Homo sapiens

Sidt2

Affinity Capture-MS

Mus musculus

ACP5

Affinity Capture-MS

Homo sapiens

SERPINC1

462

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VCP

7415

Affinity Capture-MS

Homo sapiens

GDF11

10220

Affinity Capture-MS

Homo sapiens

SARAF

Co-fractionation

Homo sapiens

PIGT

51604

Affinity Capture-MS

Homo sapiens

C1orf54

Affinity Capture-MS

Homo sapiens

LPPR2

Affinity Capture-MS

Homo sapiens

B3GALNT2

148789

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FRAS1

80144

Affinity Capture-MS

Homo sapiens

SMAD2

4087

Two-hybrid

Homo sapiens

RPN1

6184

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CASR

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

B4GALT3

8703

Affinity Capture-MS

Homo sapiens

SREBF2

6721

Two-hybrid

Homo sapiens

TMEM131

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZYG11B

Affinity Capture-MS

Homo sapiens

PTPRO

5800

Affinity Capture-MS

Homo sapiens

ASPM

259266

Affinity Capture-MS

Homo sapiens

ZPBP2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DNAJB11

51726

Affinity Capture-MS

Homo sapiens

CERCAM

51148

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TXNDC11

51061

Affinity Capture-MS

Homo sapiens

100

ASGR2

Affinity Capture-Western

Homo sapiens

101

COL14A1

7373

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

HSPA5

3309

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

103

ADAMTS4

Affinity Capture-MS

Homo sapiens

104

COLGALT2

Affinity Capture-MS

Homo sapiens

105

LOXL2

4017

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

106

CANX

821

Affinity Capture-MS

Homo sapiens

107

HSD11B1

3290

Affinity Capture-MS

Homo sapiens

108

ATF6

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

109

CALR3

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

110

EGLN3

Affinity Capture-Western

Homo sapiens

111

ZDHHC12

Affinity Capture-MS

Homo sapiens

112

CHST8

64377

Affinity Capture-MS

Homo sapiens

113

GGH

8836

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

B3GNT3

10331

Affinity Capture-MS

Homo sapiens

115

WDR25

Affinity Capture-MS

Homo sapiens

116

EMB

133418

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

117

ERLEC1

27248

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

118

RLN1

Affinity Capture-MS

Homo sapiens

119

CBLN4

Affinity Capture-MS

Homo sapiens

120

EGFR

1956

Affinity Capture-MS

Homo sapiens

121

MYO5A

4644

Affinity Capture-MS

Homo sapiens

122

LYZL1

Affinity Capture-MS

Homo sapiens

123

FBXO6

26270

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

124

PCOLCE2

26577

Affinity Capture-MS

Homo sapiens

125

CCNJL

Affinity Capture-MS

Homo sapiens

126

IL5RA

Affinity Capture-MS

Homo sapiens

127

GDAP1

54332

Affinity Capture-MS

Homo sapiens

128

NPTX1

Affinity Capture-MS

Homo sapiens

129

PLTP

5360

Affinity Capture-MS

Homo sapiens

130

LAMA1

284217

Affinity Capture-MS

Homo sapiens

131

GALNT18

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

132

TRPV1

Affinity Capture-Western

Homo sapiens

133

CREB3

Two-hybrid

Homo sapiens

134

IL12RB1

Affinity Capture-MS

Homo sapiens

135

GALC

2581

Affinity Capture-MS

Homo sapiens

136

ZNFX1

57169

Affinity Capture-MS

Homo sapiens

137

PTPRN

Affinity Capture-MS

Homo sapiens

138

HPSE

10855

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

139

HYOU1

10525

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

140

P3H3

10536

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

141

DNASE1L1

1774

Affinity Capture-MS

Homo sapiens

142

TUBB7P

56604

Affinity Capture-MS

Homo sapiens

143

POGLUT1

56983

Affinity Capture-MS

Homo sapiens

144

BMP1

649

Affinity Capture-MS

Homo sapiens

145

Slc12a1

Two-hybrid		Mus musculus
Affinity Capture-Western		Mus musculus
Affinity Capture-Western		Mus musculus

146

HUWE1

10075

Affinity Capture-MS

Homo sapiens

147

UBE2J1

51465

Affinity Capture-MS

Homo sapiens

148

HIF1A

3091

Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

149

LYZL2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

150

TTC17

55761

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

151

HSPE1

3336

Cross-Linking-MS (XL-MS)

Homo sapiens

152

LAMB1

3912

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

153

SPCS3

60559

Affinity Capture-MS

Homo sapiens

154

NAAA

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

155

TXNDC16

57544

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

156

FOXRED2

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

157

LINC00839

Protein-RNA

Homo sapiens

158

PDIA4

9601

Proximity Label-MS

Homo sapiens

159

EPHA4

2043

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

160

Sel1l

Affinity Capture-MS

Mus musculus

161

PLD6

Affinity Capture-MS

Homo sapiens

162

PLXNA1

5361

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

163

TLL2

Affinity Capture-MS

Homo sapiens

164

EDEM1

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

165

CDC6

Affinity Capture-MS

Homo sapiens

166

EMILIN2

84034

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

167

HLA-DRA

3122

Affinity Capture-MS

Homo sapiens

168

LRP1B

53353

Affinity Capture-MS

Homo sapiens

169

OS9

10956

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

170

DDX58

23586

Affinity Capture-RNA

Homo sapiens

171

EDEM3

80267

Affinity Capture-MS

Homo sapiens

172

EDEM2

Affinity Capture-MS

Homo sapiens

173

AGRN

375790

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

174

AUP1

550

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

175

ATF6B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

176

ADAMTS17

Affinity Capture-MS

Homo sapiens

177

PLD3

23646

Affinity Capture-MS

Homo sapiens

178

EOGT

285203

Affinity Capture-MS

Homo sapiens

179

BRICD5

Affinity Capture-MS

Homo sapiens

180

DCSTAMP

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

181

NXPE3

Affinity Capture-MS

Homo sapiens

182

BMP8B

Affinity Capture-MS

Homo sapiens

183

LAMB2

3913

Affinity Capture-MS

Homo sapiens

184

NCEH1

57552

Affinity Capture-MS

Homo sapiens

185

LAMA5

3911

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

186

FOXM1

Two-hybrid

Homo sapiens

187

FUT9

Affinity Capture-MS

Homo sapiens

188

B3GNT2

10678

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

189

COLGALT1

79709

Affinity Capture-MS

Homo sapiens

190

PODN

127435

Affinity Capture-MS

Homo sapiens

191

PTCH1

Affinity Capture-MS

Homo sapiens

192

CHSY3

337876

Affinity Capture-MS

Homo sapiens

193

LAMA3

3909

Affinity Capture-MS

Homo sapiens

194

TENM3

55714

Affinity Capture-MS

Homo sapiens

195

NPTX2

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which OS9 is involved

Pathway	Evidence	Source
ABC transporter disorders	TAS	Reactome
ABC-family proteins mediated transport	TAS	Reactome
Asparagine N-linked glycosylation	TAS	Reactome
Calnexin/calreticulin cycle	TAS	Reactome
Defective CFTR causes cystic fibrosis	TAS	Reactome
Disease	TAS	Reactome
Diseases of signal transduction by growth factor receptors and second messengers	TAS	Reactome
Disorders of transmembrane transporters	TAS	Reactome
ER Quality Control Compartment (ERQC)	TAS	Reactome
Hedgehog ligand biogenesis	TAS	Reactome
Hh mutants abrogate ligand secretion	TAS	Reactome
Hh mutants are degraded by ERAD	TAS	Reactome
Metabolism of proteins	TAS	Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	TAS	Reactome
Post-translational protein modification	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by Hedgehog	TAS	Reactome
Transport of small molecules	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here