Gene description for GDF11
Gene name growth differentiation factor 11
Gene symbol GDF11
Other names/aliases BMP-11
BMP11
Species Homo sapiens
 Database cross references - GDF11
ExoCarta ExoCarta_10220
Vesiclepedia VP_10220
Entrez Gene 10220
HGNC 4216
MIM 603936
UniProt O95390  
 GDF11 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF11
Molecular Function
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
Biological Process
    skeletal system development GO:0001501 TAS
    metanephros development GO:0001656 IEA
    ureteric bud development GO:0001657 IEA
    nervous system development GO:0007399 TAS
    mesoderm development GO:0007498 TAS
    cell population proliferation GO:0008283 IEA
    negative regulation of cell population proliferation GO:0008285 IEA
    spinal cord anterior/posterior patterning GO:0021512 IEA
    activin receptor signaling pathway GO:0032924 IMP
    amacrine cell differentiation GO:0035881 IEA
    camera-type eye morphogenesis GO:0048593 IEA
    roof of mouth development GO:0060021 IEA
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    type B pancreatic cell maturation GO:0072560 IEA
    negative regulation of amacrine cell differentiation GO:1902870 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    nucleoplasm GO:0005654 IDA
    protein-containing complex GO:0032991 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified GDF11 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DEFB125  
Affinity Capture-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 LY6H  
Affinity Capture-MS Homo sapiens
4 C7orf34  
Affinity Capture-MS Homo sapiens
5 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TSPY2  
Affinity Capture-MS Homo sapiens
7 HSPA5 3309
Affinity Capture-MS Homo sapiens
8 C1QTNF9B  
Affinity Capture-MS Homo sapiens
9 LCN6  
Affinity Capture-MS Homo sapiens
10 SIAE 54414
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LIPH 200879
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 IGDCC4  
Affinity Capture-MS Homo sapiens
14 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EFNA2  
Affinity Capture-MS Homo sapiens
16 MMP26  
Affinity Capture-MS Homo sapiens
17 PRSS2 5645
Affinity Capture-MS Homo sapiens
18 ERLEC1 27248
Affinity Capture-MS Homo sapiens
19 CDH23 64072
Affinity Capture-MS Homo sapiens
20 ANTXR1 84168
Affinity Capture-MS Homo sapiens
21 SLURP1  
Affinity Capture-MS Homo sapiens
22 OS9 10956
Affinity Capture-MS Homo sapiens
23 APP 351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MFAP5  
Affinity Capture-MS Homo sapiens
25 MSTN  
Affinity Capture-MS Homo sapiens
26 CLEC12B  
Affinity Capture-MS Homo sapiens
27 PRTG  
Affinity Capture-MS Homo sapiens
28 MKRN2 23609
Affinity Capture-RNA Homo sapiens
29 EDDM3B  
Affinity Capture-MS Homo sapiens
30 PLXNC1 10154
Affinity Capture-MS Homo sapiens
31 SCGB2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 C1orf54  
Affinity Capture-MS Homo sapiens
33 CRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ZNF131  
Affinity Capture-MS Homo sapiens
35 BMP7 655
Affinity Capture-MS Homo sapiens
36 PRSS8 5652
Affinity Capture-MS Homo sapiens
37 PRC1 9055
Affinity Capture-MS Homo sapiens
38 EDN3  
Affinity Capture-MS Homo sapiens
39 TDGF1  
Affinity Capture-MS Homo sapiens
40 FBLN5 10516
Affinity Capture-MS Homo sapiens
41 BAGE2  
Affinity Capture-MS Homo sapiens
42 MNAT1  
Affinity Capture-MS Homo sapiens
43 Cfc1  
Reconstituted Complex Mus musculus
44 ACVR2B  
Affinity Capture-MS Homo sapiens
45 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 C1QTNF7  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GDF11 is involved
No pathways found





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